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Research Progress of Small Molecule Compounds in Neural Differentiation of Stem Cells |
Guang-ran LI1,Wei WANG1,2,3() |
1 The First Affiliated Hospital, Jinzhou Medical University,Jinzhou 121000, China 2 Department of Orthopedics Research Institute, Jinzhou Medical University,Jinzhou 121000, China 2 Department of Orthopedics Research Institute, Jinzhou Medical University,Jinzhou 121000, China |
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Abstract Nervous system diseases occur in the central, peripheral, autonomic nervous system with sensory, motor, consciousness, autonomic nervous dysfunction as the main manifestation of the disease, is currently one of the most harmful to human diseases. With the development of stem cell biology, human beings have made remarkable progress in inducing neural differentiation of stem cells and may solve the key problems of nerve repair and regeneration. Small molecule compounds are increasingly used to intervene and study the biological behaviors of stem cells such as proliferation, differentiation and reprogramming because of their obvious advantages in convenience, controllability and functional diversity.The progress of neural cell differentiation induced by small molecule compounds in stem cells is reviewed.
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Received: 31 July 2017
Published: 04 April 2018
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[1] |
Xu Y, Shi Y, Ding S . A chemical approach to stem-cell biology and regenerative medicine. Nature, 2008,453(7193):338-344.
doi: 10.1038/nature07042
|
|
|
[2] |
Kriks S, Shim J W, Piao J , et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature, 2011,480(7378):547-551.
doi: 10.1038/nature10648
pmid: 22056989
|
|
|
[3] |
Zhang Y, Li W, Laurent T , et al. Small molecules,big roles--the chemical manipulation of stem cell fate and somatic cell reprogramming. J Cell Sci, 2012,125(23):5609-5620.
doi: 10.1242/jcs.096032
|
|
|
[4] |
Thomson J A, Itskovitz-Eldor J, Shapiro S S , et al. Embryonic stem cell lines derived from human blastocysts. Science, 1998,282(5391):1145-1147.
doi: 10.1126/science.282.5391.1145
pmid: 9804556
|
|
|
[5] |
Neely M D, Litt M J, Tidball A M , et al. DMH1,a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs:comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci, 2012,3(6):482-491.
doi: 10.1021/cn300029t
pmid: 22860217
|
|
|
[6] |
刘镕, 赵琴平, 董惠芬 , 等. TGF-β信号传导通路及其生物学功能. 中国病原生物学杂志, 2014,9(1):77-83.
|
|
|
[6] |
Liu R, Zhao Q P, Dong H F , et al. The TGF-β signaling pathways and their biological functions. Journal of Pathogen Biology, 2014,9(1):77-83.
|
|
|
[7] |
陈兵, 易斌, 鲁开智 . Smad蛋白家族调控细胞分化的研究进展. 医学研究生学报, 2013,26(5):544-547.
doi: 10.3969/j.issn.1008-8199.2013.05.024
|
|
|
[7] |
Chen B, Yi B, Lu K Z . Advances in researches on Smad proteins in cell differentiation. J Med Postgra, 2013,26(5):544-547.
doi: 10.3969/j.issn.1008-8199.2013.05.024
|
|
|
[8] |
Elkabetz Y, Panagiotakos G, Al Shamy G , et al. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev, 2008,22(2):152-165.
doi: 10.1101/gad.1616208
pmid: 18198334
|
|
|
[9] |
Park I H, Zhao R, West J A , et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature, 2008,451(7175):141-146.
doi: 10.1038/nature06534
pmid: 18157115
|
|
|
[10] |
Chambers S M, Fasano C A, Papapetrou E P , et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol, 2009,27(3):275-280.
doi: 10.1038/nbt.1529
pmid: 19252484
|
|
|
[11] |
Xu R H , Sampsell-Barron T L,Gu F,et al. NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell, 2008,3(2):196-206.
doi: 10.1016/j.stem.2008.07.001
pmid: 18682241
|
|
|
[12] |
Xu R H, Chen X, Li D S , et al. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol, 2002,20(12):1261-1264.
doi: 10.1038/nbt761
pmid: 12426580
|
|
|
[13] |
D’Amour K A, Agulnick A D, Eliazer S , et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol, 2005,23(12):1534-1541.
doi: 10.1038/nbt1163
pmid: 16258519
|
|
|
[14] |
Laflamme M A, Chen K Y, Naumova A V , et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol, 2007,25(9):1015-1024.
doi: 10.1038/nbt1327
|
|
|
[15] |
Munoz-Sanjuan I, Brivanlou A H . Neural induction,the default model and embryonic stem cells. Nat Rev Neurosci, 2002,3(4):271-280.
doi: 10.1038/nrn786
|
|
|
[16] |
Zhou J, Su P, Li D , et al. High-efficiency induction of neural conversion in human ESCs and human induced pluripotent stem cells with a single chemical inhibitor of transforming growth factor beta superfamily receptors. Stem Cells, 2010,28(10):1741-1750.
doi: 10.1002/stem.v28:10
|
|
|
[17] |
Shimojo, Onodera K , Doi- Torii Y,et al. Rapid,efficient,and simple motor neuron differentiation from human pluripotent stem cells. Mol Brain,2015,8(1):79-94.
doi: 10.1186/s13041-015-0172-4
pmid: 4666063
|
|
|
[18] |
Mica Y, Lee G, Chambers S M , et al. Modeling neural crest induction,melanocyte specification,and disease-related pigmentation defects in hESCs and patient-specific iPSCs. Cell Reports, 2013,3(4):1140-1152.
doi: 10.1016/j.celrep.2013.03.025
pmid: 3681528
|
|
|
[19] |
Du Z W, Chen H, Liu H , et al. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun, 2015,6(3):6626-6635.
doi: 10.1038/ncomms7626
pmid: 25806427
|
|
|
[20] |
Chen X, Li Q, Xu H , et al. Sodium iodate influences the apoptosis, proliferation and differentiation potential of radial glial cells in vitro. Cell Physiol Biochem, 2014,34(4):1109-1124.
doi: 10.1159/000366325
pmid: 25277056
|
|
|
[21] |
Liu H, Zhang S C . Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell Mol Life Sci, 2011,68(24):3995-4008.
doi: 10.1007/s00018-011-0770-y
|
|
|
[22] |
Maury Y, C?me J, Piskorowski RA , et al. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes. Nat Biotechnol, 2015,33(1):89-96.
doi: 10.1038/nbt.3049
pmid: 25383599
|
|
|
[23] |
Fasano C A, Chambers SM, Lee G , et al. Efficient derivation of functional floor plate tissue from human embryonic stem cells. Cell Stem Cell, 2010,6(4):336-347.
doi: 10.1016/j.stem.2010.03.001
pmid: 20362538
|
|
|
[24] |
Hargus G, Cooper O, Deleidi M , et al. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci USA, 2010,107(36):15921-15926.
doi: 10.1073/pnas.1010209107
pmid: 20798034
|
|
|
[25] |
Morizane A, Darsalia V, Guloglu M O , et al. A simple method for large-scale generation of dopamine neurons from human embryonic stem cells. J Neurosci Res, 2010,88(16):3467-3478.
doi: 10.1002/jnr.22515
pmid: 20981866
|
|
|
[26] |
Xi J, Liu Y, Liu H , et al. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells, 2012,30(8):1655-1663.
doi: 10.1002/stem.1152
pmid: 22696177
|
|
|
[27] |
李进, 侯俊, 胡敏 . 干细胞基础研究热点及应用难题. 解放军医学杂志, 2012,37(6):659-661.
|
|
|
[27] |
Li J, Hou J, Hu M . Hot spots in fundamental stem cell research and their difficulties in application studies. Med J Chin PLA, 2012,37(6):659-661.
|
|
|
[28] |
姜楠, 潘学峰 . 表观遗传学及现代表观遗传生物医药技术的发展. 生物技术通报, 2015,31(4):105-119.
doi: 10.13560/j.cnki.biotech.bull.1985.2015.03.005
|
|
|
[28] |
Jiang N, Pan X F . The Developments of epigenetics and epigenetics-based modern biomedicine and pharmaceutics. Biotechnology Bulletin, 2015,31(4):105-119.
doi: 10.13560/j.cnki.biotech.bull.1985.2015.03.005
|
|
|
[29] |
Alexanian A R . An efficient method for generation of neural-like cells from adult human bone marrow-derived mesenchymal stem cells. Regen Med, 2010,5(6):891-900.
doi: 10.2217/rme.10.67
pmid: 21082889
|
|
|
[30] |
Zhang Z, Alexanian A R . Dopaminergic-like cells from epigenetically reprogrammed mesenchymal stem cells. J Tissue Eng Regen Med, 2012,16(11):2708-2714.
doi: 10.1111/j.1582-4934.2012.01591.x
pmid: 22681532
|
|
|
[31] |
Zhang Z, Alexanian A R . The neural plasticity of early-passage human bone marrow-derived mesenchymal stem cells and their modulation with chromatin-modifying agents. J Tissue Eng Regen Med, 2014,8(5):407-413.
doi: 10.1002/term.1535
pmid: 22674835
|
|
|
[32] |
Alexanian A R, Liu Q S, Zhang Z . Enhancing the efficiency of direct reprogramming of human mesenchymal stem cells into mature neuronal-like cells with the combination of small molecule modulators of chromatin modifying enzymes,SMAD signaling and cyclic adenosine monophosphate levels. Int J Biochem Cell Biol, 2013,45(8):1633-1638.
doi: 10.1016/j.biocel.2013.04.022
|
|
|
[33] |
Amirpour N, Razavi S, Esfandiari E , et al. Hanging drop culture enhances differentiation of human adipose-derived stem cells into anterior neuroectodermal cells using small molecules. Int J Dev Neurosci, 2017,59(7):21-30.
doi: 10.1016/j.ijdevneu.2017.03.002
pmid: 28285945
|
|
|
[34] |
Viczian A S . Advances in retinal stem cell biology. J Ophthalmic Vis Res, 2013,8(2):147-159.
pmid: 23943690
|
|
|
[35] |
Lagutin O V, Zhu C C, Kobayashi D , et al. Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev, 2003,17(3):368-379.
doi: 10.1101/gad.1059403
pmid: 12569128
|
|
|
[36] |
Xie S, Lu F, Han J , et al. Efficient generation of functional Schwann cells from adipose-derived stem cells in defined conditions. Cell Cycle, 2017,16(9):841-851.
doi: 10.1080/15384101.2017.1304328
pmid: 28296571
|
|
|
[37] |
付艳宾, 龙媛, 谢欣 . 全化学诱导体细胞重编程和转分化. 生命科学, 2016,28(8):941-948.
|
|
|
[37] |
Fu Y B, Long Y, Xie X . Recent progress in chemical-induced somatic cell reprogramming and trans-differentiation. Chinese Bulletin of Life Sciences, 2016,28(8):941-948.
|
|
|
[38] |
Thoma E C, Merkl C, Heckel T , et al. Chemical conversion of human fibroblasts into functional Schwann cells. Stem Cell Reports, 2014,3(4):539-547.
doi: 10.1007/978-1-4939-7649-2_8
pmid: 25358782
|
|
|
[39] |
Cheng L, Hu W, Qiu B , et al. Generation of neural progenitor cells by chemical cocktails and hypoxia. Cell Res, 2014,24(6):665-679.
doi: 10.1038/cr.2014.32
pmid: 4423089
|
|
|
[40] |
Hu W, Qiu B, Guan W , et al. Direct conversion of normal and alzheimer’s disease human fibroblasts into neuronal cells by small molecules. Cell Stem Cell, 2015,17(2):204-212.
doi: 10.1016/j.stem.2015.07.006
pmid: 26253202
|
|
|
[41] |
Li X, Zuo X, Jing J , et al. Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons. Cell Stem Cell, 2015,17(2):195-203.
doi: 10.1016/j.stem.2015.06.003
pmid: 26253201
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