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中国生物工程杂志

China Biotechnology
China Biotechnology  2016, Vol. 36 Issue (11): 116-121    DOI: 10.13523/j.cb.20161116
    
Genetically Modified “Golden Rice”: Development and Challenge
WANG Yu guang1, CAI Jin yang1, MA Cai yun2, HU Rui fa1
1. School of Management and Economics, Beijing Institute of Technology, Beijing 100081, China;
2. Library, Beijing Institute of Technology, Beijing 100081, China
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Abstract  

Vitamin A deficiency is a serious malnutrition, which can lead to many health problems, especially for women and children in poor areas. In order to cope with this challenge, Ingo Potrykus and Peter Beyer, from Switzerland and Germany respectively, have invented the so called "Golden Rice" through cloning and transfering PSY gene into rice by using modern biotechnology,which is rich in carotene and can effectively supplement the vitamin A of the human body. However, there is a debate about the understanding of the "Golden Rice". The history of the development of "Golden Rice", the scientific effects and social benefits were traced and studied based on scientific literatures from Web of Science. The conclusion shows that the "Golden Rice" is safe and effective, and the earlier the commercialization of "Golden Rice", it will bring the human health and social welfare. However,the whole society needs to overcome some technical and political obstacles or the commercialization of the "Golden Rice" is still far away.



Key wordsVitamin A      "Golden Rice"      Commercialization      Welfare      Carotene     
Received: 23 August 2016      Published: 25 November 2016
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Cite this article:

WANG Yu guang, CAI Jin yang, MA Cai yun, HU Rui fa. Genetically Modified “Golden Rice”: Development and Challenge. China Biotechnology, 2016, 36(11): 116-121.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20161116     OR     https://manu60.magtech.com.cn/biotech/Y2016/V36/I11/116

[1] Datta S, Datta K, Parkhi V, et al.Golden rice:introgression, breeding, and field evaluation. Euphytica,2007,154(3):271-278.
[2] Bollineni H, Krishnan S, Gopala S, et al.Marker assisted biofortification of rice with pro-vitamin A using transgenic Golden Rice (R) lines:progress and prospects.Indian Journal of Genetics and Plant Breeding, 2014,74(4):624-630.
[3] Moghissi A,Pei S Q,Liu Y Z,Golden rice:scientific, regulatory and public information processes of a genetically modified organism, Critical Reviews in Biotechnology,2016,36(3):535-541.
[4] Humphrey J H, West K P, Sommer A. Vitamin A deficiency and attributable mortality among under-5-year-olds.WHO Bull, 1992,70(2):225-232.
[5] Ye X D,Al-Babili S, Kloti A, et al.Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm,Science, 2000,287(5451):303-305.
[6] Chong M, Acceptance of golden rice in the Philippine ‘rice bowl’, Nature Biotechnology, 2003,21(9):971-972.
[7] 杨雄,颜志华,邢思悦,"黄金大米"真相.[2016-07-16]. http://www.nbweekly.com/news/tech/201209/31187.aspx. Yang X,Yan Z H,Xing S Y.The truth of golden rice. Open Access Overview.[2016-07-16].http://www.nbweekly.com/news/tech/201209/31187.aspx.
[8] 贾鹤鹏.谁冤枉了"黄金大米".[2016-07-16].http://www.guokr.com/article/346383/. Jia H P, Who misunderstand the golden rice? Open Access Overview.[2016-07-16].http://www.guokr.com/article/346383/.
[9] 中国生物工程学会."黄金大米"的科学内涵与来龙去脉.[2016-07-16].http://view.news.qq.com/a/20120911/000034.htm. CSBT,The scientific connotation and the detailed events of the golden rice,Open Access Overview.[2016-07-16].http://view.news.qq.com/a/20120911/000034.htm.
[10] Burkhardt K,Beyer P, Wunn J et al,Transgenic rice (Oryza sativa) endosperm expressing daffodil (Narcissus pseudonarcissus) phytoene synthase accumulates phytoene, a key intermediate of provitamin A biosynthesis.Plant Journal,1997,11(5):1071-1078.
[11] Beyer P, Al-Babili S, Ye X D, et al.Golden rice:introducing the beta-carotene biosynthesis pathway into rice endosperm by genetic engineering to defeat vitamin A deficiency.Journal of Nutrition,2002,132(3):506-510.
[12] Datta K, Baisakh N, Oliva N, et al.Bioengineered golden indica rice cultivars with beta-carotene metabolism in the endosperm with hygromycin and mannose selection systems, Plant Biotechnology Journal,2003,1(2):81-90.
[13] Paine A, Shipton A, Chaggar S, et al.Improving the nutritional value of Golden Rice through increased pro-vitamin A content,Nature Biotechnology, 2005,23(4):482-487.
[14] Datta K, Rai M, Parkhi V, et al. Improved ‘golden’ indica rice and post-transgeneration enhancement of metabolic target products of carotenoids (beta-carotene) in transgenic elite cultivars (IR64 and BR29). Current Science, 2006,91(7):935-939.
[15] Al-Babili S, Hoa C,Schaub P. Exploring the potential of the bacterial carotene desaturase CrtI to increase the beta-carotene content in Golden Rice. Journal of Experimental Botany,2006,57(4):1007-1014.
[16] Potrykus I,Golden rice and beyond. Plant Physiology, 2001,125(3):1157-1161.
[17] Tang G W, Qin J, Dolnikowski G, et al.Golden Rice is an effective source of vitamin A, American Journal of Clinical Nutrition,2009,89(6):1776-1783.
[18] Tang G W, Hu Y M, Yin S A, et al.Beta-carotene in Golden Rice is as good as beta-carotene in oil at providing vitamin A to children.American Journal of Clinical Nutrition,2012,96(3):658-664.
[19] Yu X, Li W. Informed consent and ethical review in Chinese Human Experimentation:reflections on the "Golden Rice Event". Biotechnology Law Roport, 2014,33(4):155-160.
[20] Li P, Dong J Y, Yang S F,et al.Impact of beta-carotene transgenic rice with four synthetic genes on rhizosphere enzyme activities and bacterial communities at different growth stages.European Journal of Soil Biology,2014,65:40-46.
[21] Dawe D,Robertson R, Unnevehr L.Golden rice:what role could it play in alleviation of vitamin A deficiency. Food Policy, 2002,27(5):541-560.
[22] Zimmermann R, Qaim M. Potential health benefits of Golden Rice:a Philippine case study. Food Policy, 2004,29(2):147-168.
[23] Stein A, Sachdev S, Qaim M. Genetic engineering for the poor:Golden Rice and public health in India. Development,2008,36(1):144-158.
[24] Qaim M. Benefits of genetically modified crops for the poor:household income, nutrition, and health. New Biotechnology, 2010,27(5):552-557.
[25] Wesseler J, Zilberman D. The economic power of the Golden Rice opposition.Environment and Development Economics,2014,19(6):724-742.
[26] Eisenstein M. Biotechnology:against the grain. Nature,2014, 514(7524):S55-S57.
[27] Nestle M.Genetically engineered golden rice unlikely to overcome vitamin A deficiency. Journal of The American Dietetic Association,2001,101(3):289-290.

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