|
|
|
| The Current Research and Development Status of Cell Drug |
| WANG Dian-liang1, DU Juan2 |
1 Tissue Engineering and Regenerative Medicine Laboratory, The General Hospital of The PLA Rocket Force, Beijing 100088, China;
2 Medical Affairs Department, The General Hospital of The PLA Rocket Force, Beijing 100088, China |
|
|
|
Abstract In recent years, the research of cell drug has been paid more attention at home and abroad. Stem cell drug, in particular, has become a hot research field around the world. The vast majority of stem cell drugs in various countries are still in the research stage, and only a few of stem cell drugs have come into the market. The currently developing stem cell drugs are focused on the treatment of chronic diseases (arthritis, diabetes and cancer, etc.) and heart related diseases (myocardial infarction, heart failure, etc.). Some traditional somatic cell drugs (such as chondrocytes, cardiac muscle cells, islet cells, etc.) and immune cell drugs have already been used in clinic.
|
|
Received: 04 February 2016
Published: 02 March 2016
|
|
|
|
|
| [1] Peng Y.The patentability of human embryonic stem cell technology in China. Nat Biotechnol,2016,34(1):37-39.
[2] Plaza Reyes A, Petrus-Reurer S, Antonsson L, et al. Xeno-free and defined human embryonic stem cell-derived retinal pigment epithelial cells functionally integrate in a large-eyed preclinical model.Stem Cell Reports,2016,6(1):9-17.
[3] Sugarman J. Human stem cell ethics:beyond the embryo. Cell Stem Cell, 2008,2(6):529-533.
[4] Tartarini D, Mele E. Adult stem cell therapies for wound healing:biomaterials and computational models.Front Bioeng Biotechnol,2016,3:206.
[5] Clevers H. What is an adult stem cell.Science, 2015,350(6266):1319-1320.
[6] Devitt S M, Carter C M, Dierov R, et al.Successful isolation of viable adipose-derived stem cells from human adipose tissue subject to long-term cryopreservation:positive implications for adult stem cell-based therapeutics in patients of advanced age.Stem Cells Int,2015,2015:146421.
[7] Branch M J, Yu W Y, Sheridan C, et al.Isolation of adult stem cell populations from the human cornea.Methods Mol Biol,2015,1235:165-177.
[8] Park B W.Dental tissues as adult stem cell source. J Korean Assoc Oral Maxillofac Surg,2013,39(2):41-42.
[9] Martinez-Schlurmann N I, Rampa S, Speicher D G, et al.Prevalence, predictors and outcomes of cardiopulmonary resuscitation in hospitalized adult stem cell transplant recipients in the United States:not just opening the black box but exploring an opportunity to optimize.Bone Marrow Transplant,2015,50(12):1578-1581.
[10] Fukada S, Ma Y, Uezumi A. Adult stem cell and mesenchymal progenitor theories of aging.Front Cell Dev Biol,2014,2:10.
[11] Trainor N, Pietak A, Smith T. Rethinking clinical delivery of adult stem cell therapies.Nat Biotechnol,2014,32(8):729-735.
[12] Erbey F, Atay D, Akcay A, et al.Mesenchymal stem cell treatment for steroid refractory graft-versus-host disease in children:A Pilot and First Study from Turkey.Stem Cells Int,2016,2016:1641402.
[13] Aras Y, Sabanci P A, Kabatas S, et al. The effects of adipose tissue-derived mesenchymal stem cell transplantation during the acute and subacute phases following spinal cord injury.Turk Neurosurg,2016,26(1):127-139.
[14] Wang L, Zhang Y, Li H, et al.Clinical observation of employment of umbilical cord derived mesenchymal stem cell for juvenile idiopathic arthritis therapy.Stem Cells Int,2016,2016:9165267.
[15] Pati S, Muthuraju S, Hadi R A, et al.Neurogenic plasticity of mesenchymal stem cell, an alluring cellular replacement for traumatic brain injury.Curr Stem Cell Res Ther,2016,11(2):149-157.
[16] Rainone V, Martelli C, Ottobrini L, et al. Immunological characterization of whole tumour lysate-loaded dendritic cells for cancer Immunotherapy.PLoS One,2016,11(1):e0146622.
[17] Wei F Q, Sun W, Wong T S, et al. Eliciting cytotoxic T lymphocytes against human laryngeal cancer-derived antigens:evaluation of dendritic cells pulsed with a heat-treated tumor lysate and other antigen-loading strategies for dendritic-cell-based vaccination.J Exp Clin Cancer Res, 2016,35(1):18.
[18] Wei X C, Yang D D, Han X R, et al. Bioactivity of umbilical cord blood dendritic cells and anti-leukemia effect.Int J Clin Exp Med, 2015,8(10):19725-19730.
[19] Chen Y, Lin J, Guo Z Q, et al.MHC I-related chain a expression in gastric carcinoma and the efficacy of immunotherapy with cytokine-induced killer cells. Am J Cancer Res,2015,5(10):3221-3230.
[20] Wang Y, Xu Z, Zhou F, et al. The combination of dendritic cells-cytotoxic T lymphocytes/cytokine-induced killer (DC-CTL/CIK) therapy exerts immune and clinical responses in patients with malignant tumors. Exp Hematol Oncol,2015,4:32.
[21] Li W, Wang Y, Kellner D B, et al. Efficacy of cytokine-induced killer cells in the treatment of elderly patients with metastatic pancreatic adenocarcinoma.Cent Eur J Immunol,2015,40(2):188-193. |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
