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中国生物工程杂志

China Biotechnology
China Biotechnology  2016, Vol. 36 Issue (7): 104-111    DOI: 10.13523/j.cb.20160714
    
Subclasses Selection in Therapeutic Antibody Development
LV Ruo-yun, CHEN Chen, WEI Jing-shuang
NCPC New Drug Research and Development Co. Ltd., State Key Laboratory of Antibody Research & Development, Shijiazhuang 050015, China
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Abstract  

Therapeutic antibody drugs with specificity and efficiency have been developed for different indications.The therapeutic antibody drugs have frameworks from IgG, most of which belong to the IgG1 isotype. Due to various subclasses with different structure and function, affect the physical and chemical properties, biological activity and the ability to trigger effector function and so on, in the process of the research and development of therapeutic antibody drugs, it is important to choose the suitable antibody subclass in design to achieve the desired effect and reduce side effects. The curative related effect of choosing IgG subclass and the development of selecting of IgG subclass for the research and application were reviewed, in order to provide new ideas for therapeutic antibody drugs development.



Key wordsTherapeutic antibody      Subclass selection      Subclasses     
Received: 18 April 2016      Published: 25 July 2016
ZTFLH:  Q819  
Cite this article:

LV Ruo-yun, CHEN Chen, WEI Jing-shuang. Subclasses Selection in Therapeutic Antibody Development. China Biotechnology, 2016, 36(7): 104-111.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20160714     OR     https://manu60.magtech.com.cn/biotech/Y2016/V36/I7/104

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