Analysis of Antibiotics Quantification Methods

doi:10.13523/j.cb.20160616

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China Biotechnology ›› 2016, Vol. 36 ›› Issue (6) : 119-126. DOI: 10.13523/j.cb.20160616

Analysis of Antibiotics Quantification Methods

SHEN Wei-tao¹, WANG Ming-yu¹, WANG Yun-kun², WANG Xin-hua², XU Hai¹

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Abstract

Being antibacterial chemicals, antibiotics play a very important role in modern medication. The Chinese pharmacopoeia was revised in 2015 which included 363 antibiotics, and introduced four methods to measure the content of antibiotics. A summary of antibiotics measurement methods showed that among the 363 antibiotics, 275 antibiotics are measured using high performance liquid chromatography, 75 antibiotics are measured using microbial assays, 8 antibiotics are measured using ultraviolet-visible spectrophotometry, and only 5 antibiotics are measured by titration. A summary of methods for the quantification of the content of antibiotics based on the latest Chinese pharmacopoeia revised in 2015 was provided and analyzed, hoping to provide a reference in the determination of the content of residual environmental antibiotic.

Key words

HPLC / The Chinese pharmacopoeia / Quantification technique / Antibiotics

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SHEN Wei-tao, WANG Ming-yu, WANG Yun-kun, WANG Xin-hua, XU Hai. Analysis of Antibiotics Quantification Methods[J]. China Biotechnology, 2016, 36(6): 119-126 https://doi.org/10.13523/j.cb.20160616

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