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中国生物工程杂志

China Biotechnology
China Biotechnology  2016, Vol. 36 Issue (6): 92-99    DOI: 10.13523/j.cb.20160613
    
Application of Hyaluronic Acid on the Cartilage Differentiation of Mesenchymal Stem Cells
ZHANG Qing-fang, LIU Ru-ming, XIAO Jian-hui
Research Center of Translational Medicine, Guizhou Province, Affiliated Hospital of Zunyi Medical College, Zunyi 563000, China
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Abstract  

With the development of tissue engineering, the use of mesenchymal stems cells (MSCs) differentiation into chondrocytes, to treat the articular cartilage injury, induced by osteoarthritis or joint trauma, has been attracting more and more attention. Hyaluronic acid (HA), a acidic polysaccharide macromolecules, is one of the main components of cartilage matrix and possess some characteristics such as biocompatibility and biodegradability, and can be used as excellent natural biological material. It has been a long history of HA which is used as scaffold material on repair cartilage defect. In recent years, some studies found that HA not only could be used as scaffold material, but also a regulator factor, applied to differentiate into cartilage. The application of MSCs differentiating into cartilage cells combined with HA in recent years were outlined. It will provide new idea for the clinical application of tissue-engineered cartilage on the basis of the MSCs.



Key wordsMesenchymal stem cells      Regulatory factor      Cartilage differentiation      Hyaluronic acid      Scaffold     
Received: 04 November 2015      Published: 02 March 2016
ZTFLH:  R968  
Cite this article:

ZHANG Qing-fang, LIU Ru-ming, XIAO Jian-hui. Application of Hyaluronic Acid on the Cartilage Differentiation of Mesenchymal Stem Cells. China Biotechnology, 2016, 36(6): 92-99.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20160613     OR     https://manu60.magtech.com.cn/biotech/Y2016/V36/I6/92

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