The Construction and Analysis of the Coexpression Network for the Gene Related to Renal Tumor

doi:10.13523/j.cb.20160205

China Biotechnology

2016, Vol. 36

Issue (2): 30-37 DOI: 10.13523/j.cb.20160205

The Construction and Analysis of the Coexpression Network for the Gene Related to Renal Tumor

LIANG Dong, XING Yong-qiang, CAI Lu

School of Mathematics, Physics and Biological Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, China

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Abstract

As one of common cancers in urinary system, the morbidity of renal tumor is increasing year by year. Firstly, the genes differentially expressed were screened based on Affymetrix hgu133b microarray data. The algorithm of Weighted Gene Co-expression Network Analysis was used to construct the co-expression network of the genes differentially expressed in renal tumor. Secondly, the module that is closely related with the tumor and hub genes were selected by analyzing the correlation patterns of the genes differentially expressed between normal and tumor tissues in kidney. Finally, the Gene Ontology enrichment of the hub genes was analyzed. Cell aging is one mechanism of suppressing tumorigenesis. The results indicated hub genes PLA2R1 and TBX3 are related to cell aging and could have an important effect on the tumor formation. The results corresponded with the investigation that gene PLA2R1 suppresses tumorigenesis in the kidney by promoting cellular senescence.

Key words： Renal tumor Co-expression network WGCNA Hub gene GO analysis

Received: 23 November 2015 Published: 14 December 2015

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Cite this article:

LIANG Dong, XING Yong-qiang, CAI Lu. The Construction and Analysis of the Coexpression Network for the Gene Related to Renal Tumor. China Biotechnology, 2016, 36(2): 30-37.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20160205 OR https://manu60.magtech.com.cn/biotech/Y2016/V36/I2/30

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