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中国生物工程杂志

China Biotechnology
China Biotechnology  2014, Vol. 34 Issue (12): 129-136    DOI: 10.13523/j.cb.20141218
    
Industrialization Strategy Research on Domestic Marine Anticancer Drugs
LIN Yi-Jun
Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China
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Abstract  

The marine has a largely source of novel compounds with potent anticancer activity and receives extensive attention from researchers. Recent studies in the field of marine anticancer drugs have revealed promising compounds with proven anticancer activity. Three examples are cytarabine, ecteinascidin-743 and eribulin mesylate, which represent the first three described marine anticancer drugs. In addition, there are a number of marine anticancer products in anticancer preclinical or clinical trials. The domestic studies of marine anticancer products play an important role in the international studies. But they are seriously out of line with the industrialization. The scientific advancements and development directions in marine anticancer drugs were examined. It analysis the industrialization problems in domestic marine anticancer drugs, such as insufficient development of marine anticancer resources, lack of intellectual property rights, insufficient capital investment, long period of clinical trials and so on. In order to solve the problems existing in industrial development and promote the healthy and orderly development of domestic marine anticancer drugs, highlights the viewpoint that the application rate of marine anticancer products can be increased greatly by the research system of autonomous intellectual property drug based on market demand and multidisciplinary technology in the "Industry-University-Institute" cooperation mode. The purpose is to put forward some useful suggestions for the industrialization of domestic marine anticancer drugs from the point of key technologies, market outlook and industrial policies.



Key wordsAnticancer      "Industry-University-Institute"      cooperation      Intellectual property      Industrialization     
Received: 28 July 2014      Published: 25 December 2014
ZTFLH:  Q819  
Cite this article:

LIN Yi-Jun. Industrialization Strategy Research on Domestic Marine Anticancer Drugs. China Biotechnology, 2014, 34(12): 129-136.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20141218     OR     https://manu60.magtech.com.cn/biotech/Y2014/V34/I12/129


[1] Schumacher M, Kelkel M, Dicato M, et al. Gold from the sea: marine compounds as inhibitors of the hallmarks of cancer. Biotechnology Advances, 2011, 29(5): 531-547.

[2] Dharmaraj S. Marine streptomyces as a novel source of bioactive substances. World Journal of Microbiology and Biotechnology, 2010, 26(12): 2123-2139.

[3] 管华诗, 王曙光. 中华海洋本草. 2009, 232-259. Guan S H, Wang S G. China marine materia medica.2009, 232-259.

[4] 邢桂兰, 田树红, 符健. 海洋细菌SSQ500的鉴定及其发酵产物抗肿瘤作用机制研究. 微生物学通报, 2013, 40(6): 1068-1073. Xing G L, Tian S H, Fu J. Identification of marine bacteria SSQ500 and the antitumor mechanism of fermentation products. Microbiology China,2013, 40(6): 1068-1073.

[5] Newman D J, Cragg G M. Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development. Marine Drugs, 2014, 12(1): 255-278.

[6] Huyck T K, Gradishar W, Manuguid F, et al. Eribulin mesylate. Nature Reviews Drug Discovery, 2011, 10(3): 173-174.

[7] Sarfaraj H M, Sheeba F, Saba A, et al. Marine natural products: a lead for anti-cancer. Indian Journal of Marine Sciences, 2012, 41: 27-39.

[8] Jiang C S, Muller W E G, Schroder H C, et al. Disulfide and multisulfide-containing metabolites from marine organisms. Chemical Reviews, 2011, 112(4): 2179-2207.

[9] Kawagishi F, Toma T, Inui T, et al. Total synthesis of ecteinascidin 743. Journal of the American Chemical Society, 2013, 135(37): 13684-13687.

[10] Pettit G R, Kamano Y, Herald C L, et al. Structure of bryostatin 4. An important antineoplastic constituent of geographically diverse Bugula neritina (Bryozoa). Journal of the American Chemical Society, 1984, 106(22): 6768-6771.

[11] Liu Y, Morgan J B, Coothankandaswamy V, et al. The Caulerpapigment caulerpin inhibits HIF-1 activation and mitochondrial respiration. Journal of Natural Products, 2009, 72(12): 2104-2109.

[12] Fuller R W, Cardellina J H, Kato Y, et al. A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. Journal of medicinal chemistry, 1992, 35: 3007-3011.

[13] Lin A S, Engel S, Smith B A, et al. Structure and biological evaluation of novel cytotoxic sterol glycosides from the marine red alga Peyssonnelia sp.. Bioorganic & Medicinal Chemistry, 2010, 18(23): 8264-8269.

[14] Colas S, Mahéo K, Denis F, et al. Sensitization by dietary docosahexaenoic acid of rat mammary carcinoma to anthracycline: a role for tumor vascularization. Clinical Cancer Research, 2010, 12(19): 5879-5886.

[15] Cheng R B, Lin X Z, Wang Z K, et al. Establishment of a transgene expression system for the marine microalga Schizochytrium by 18S rDNA-targeted homologous recombination. World Journal of Microbiology and Biotechnology, 2011, 27(3): 737-741.

[16] Wyche T P, Hou Y, Braun D, et al. First natural analogs of the cytotoxic thiodepsipeptide thiocoraline A from a marine Verrucosispora sp.. The Journal of Organic Chemistry, 2011, 76(16): 6542-6547.

[17] Lam K S, Lloyd G K, Neuteboom S T C, et al. From natural product to clinical trials: NPI-0052 (salinosporamide A), a marine actinomycete-derived anticancer agent. Natural Products Chemistry for Drug Discovery, 2010, 355-373.

[18] Zheng L H, Wang Y J, Sheng J, et al. Antitumor peptides from marine organisms. Marine Drugs, 2011, 9(10): 1840-1859.

[19] Gerwick W H, Hamel E, White J D, et al. Integrating disciplines in the natural products sciences: the story of Curacin A. Planta Medica, 2012, 78(11):1-19.

[20] Lee J, Currano J N, Carroll P J, et al. Didemnins, tamandarins and related natural products. Natural Product Reports, 2012, 29(3): 404-424.

[21] Sivapathasekaran C, Das P, Mukherjee S, et al. Marine bacterium derived lipopeptides: characterization and cytotoxic activity against cancer cell lines. International Journal of Peptide Research and Therapeutics, 2010, 16(4): 215-222.

[22] Moushumi P A, Jayachandran S. Induction of apoptosis and cell cycle arrest by bis(2-ethylhexyl) phthalate produced by marine Bacillus pumilus MB 40. Chemico-biological Interactions, 2012, 195(2): 133-143.

[23] Maloney K N, Macmillan J B, Kauffman C A, et al. Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete. Organic Letters, 2009, 11(23): 5422-5424.

[24] 陈劲平, 林逸君, 敬科举, 等. 不同流加策略对内生真菌拟茎点霉生产去乙酰真菌环氧乙酯的影响. 厦门大学学报(自然科学版), 2010, 49(5): 676-681. Chen J P, Lin Y J, Jing K J, et al. Effect of different feeding modes on deacetylmycoepoxydiene production by an endophytic fungi Phomopsis sp. Journal of Xiamen University (Natural Science), 2010, 49(5):676681.

[25] 管华诗. 把握海洋药物研发的历史机遇. 中国海洋药物, 2013, 1: 14-15. Guan H S. Grasp the historical opportunity of marine drug. Chinese Journal of Marine Drugs, 2013, 1: 14-15.

[26] 张书军, 焦炳华. 世界海洋药物现状与发展趋势. 中国海洋药物, 2012, 2: 012. Zhang S J, Jiao B H. Current situation and development trend of marine drugs. Chinese Journal of Marine Drugs, 2012, 2: 012.

[27] 闫娟娟. 我国创新药物实现产业化的策略探讨. 中国医药管理杂志, 2011, 19(5): 397-399. Yan J J. Discussion on the strategy for industrialization of innovative medicine in our country. Journal of Traditional Chinese Medicine Management, 2011, 19(5): 397-399.

[28] Montaser R, Luesch H. Marine natural products: a new wave of drugs?. Future Medicinal Chemistry, 2011, 3(12): 1475-1489.

[29] 孙继鹏, 易瑞灶, 吴皓, 等. 海洋药物的研发现状及发展思路. 海洋开发与管理, 2013,3:7-13. Sun J P, Yi R Z, Wu H, et al. Research status and development ideas of marine drugs. Ocean Development and Management, 2013,3:7-13.

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