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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2014, Vol. 34 Issue (8): 97-104    DOI: 10.13523/j.cb.20140815
    
A Review for Microbial Production of C4 Dicarboxylatic Acids
XU Guo-qiang1,2,3, WU Man-zhen1,3
1. National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wusi 214122, China;
2. The Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wusi 214122, China;
3. School of Biotechnology, Jiangnan University, Wuxi 214122, China
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Abstract  

As metabolites in TCA cycle, C4 dicarboxylatic acids such as malic acid, fumaric acid and succinic acid, are widely used in food, pharmaceutical and chemical industries, the potential total annual demand for C4 dicarboxylatic acids is very huge. C4 dicarboxylatic acids production by microbial fermentation is attracting increasing attention. Some microorganism isolated from nature can produce large amounts of C4 dicarboxylatic acids, however, these processes are suffered many weakness. In contrast, the model microorganisms harbor many advantages for C4 dicarboxylatic acids production and become focus of study at home and abroad. Recent research progress in the production of C4 dicarboxylatic acids by microbial fermentation, including production of C4 dicarboxylatic acids by natural producing microorganism and its mutants, metabolic engineering of type strain for C4 dicarboxylatic acids production, and metabolism regulation of fermentation process were reviewed. Finally, the problems to be solved and future research direction was also proposed.

Key words： Dicarboxylatic acids      Microbial fermentation      System metabolic engineering     
Received: 26 May 2014      Published: 25 August 2014
ZTFLH:  Q819  
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Cite this article:

XU Guo-qiang, WU Man-zhen. A Review for Microbial Production of C4 Dicarboxylatic Acids. China Biotechnology, 2014, 34(8): 97-104.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20140815     OR     https://manu60.magtech.com.cn/biotech/Y2014/V34/I8/97


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