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中国生物工程杂志

China Biotechnology
China Biotechnology  2014, Vol. 34 Issue (8): 81-87    DOI: 10.13523/j.cb.20140813
    
DNA Methylation and microRNAs
MAN Chao-lai, TANG Gao-xia, ZHAO Li, LI Feng, ZHEN Xin
College of Life Science and Technology, Harbin Normal University, Harbin 150025, China
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Abstract  

DNA methylation and microRNAs (miRNAs) interact and regulate each other in cells, which co-regulate the expression of its downstream target genes, and play important functions in the physiological and pathological processes of cell growth, metabolism, immune, tumor and cardiovascular diseases, etc. The research situation of DNA methylation and miRNAs was summarized briefly. Then, DNA methylation changes under the regulation of miRNAs were analyzed; changes in miRNAs expression and activity under the regulation of DNA methylation were discussed. The feedback regulatory relationships between DNA methylation and miRNAs were also reviewed. Finally, the application prospects of DNA methylation and miRNAs were also discussed briefly. Studies on the regulatory network between DNA methylation and miRNAs, can supply references for further study and application of epigenetics.



Key wordsDNA methylation      microRNA      Tumor      Expression     
Received: 27 February 2014      Published: 25 August 2014
ZTFLH:  Q789  
Cite this article:

MAN Chao-lai, TANG Gao-xia, ZHAO Li, LI Feng, ZHEN Xin. DNA Methylation and microRNAs. China Biotechnology, 2014, 34(8): 81-87.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20140813     OR     https://manu60.magtech.com.cn/biotech/Y2014/V34/I8/81


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