The Roles of Trehalose and Heat Shock Proteins for Enhancing Ethanol Tolerance of <em>Saccharomyces cerevisiae</em>

doi:10.13523/j.cb.20140612

China Biotechnology

2014, Vol. 34

Issue (06): 84-89 DOI: 10.13523/j.cb.20140612

The Roles of Trehalose and Heat Shock Proteins for Enhancing Ethanol Tolerance of Saccharomyces cerevisiae

FANG Hua, LI Hao

College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

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Abstract

During the process of bioethanol production, Saccharomyces cerevisiae cells are often stressed by the accumulated ethanol, which can lead to inhibition of S. cerevisiae growth and low bioethanol yield. To maintain the survival, S. cerevisiae cells have evolved a set of stress responses to environmental stimuli including ethanol stress. Fully understanding the mechanism of S. cerevisiae responses to ethanol will facilitate the development of strategies to improve the ethanol tolerance of S. cerevisiae and contribute to the construction of industrial feasible strains with high bioethanol yield. Under the stress of accumulated ethanol, some protectants, such as trehalose, heat shock proteins (HSPs), and proline can improve the ethanol tolerance of S.cerevisiae cells. As an important carbon source and energy storage material, trehalose can not only stabilize the cell membranes, proteins and nucleic acids, but also enhance the ethanol tolerance of S. cerevisiae. Furthermore, the up-regulation of HSPs can also improve the ethanol tolerance of S. cerevisiae cells. The progresses of protective roles of trehalose and HSPs for enhancing the ethanol tolerance of S. cerevisiae were focused on.

Key words： Saccharomyces cerevisiae Ethanol stress Trehalose Heat shock protein

Received: 22 October 2013 Published: 25 June 2014

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Cite this article:

FANG Hua, LI Hao. The Roles of Trehalose and Heat Shock Proteins for Enhancing Ethanol Tolerance of Saccharomyces cerevisiae. China Biotechnology, 2014, 34(06): 84-89.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20140612 OR https://manu60.magtech.com.cn/biotech/Y2014/V34/I06/84

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