Research Progress of Avilamycin Biosynthesis

doi:10.13523/j.cb.2009022

China Biotechnology

2021, Vol. 41

Issue (1): 94-102 DOI: 10.13523/j.cb.2009022

Research Progress of Avilamycin Biosynthesis

YU Guang-hai(

),PENG Hai-fen,WANG Ao-yu

College of Bioengineering, Henan University of Technology, Zhengzhou 450001, China

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Abstract

Avilamycin, an oligosaccharide antibiotic with strong antibacterial effect to Gram-positive intestinal pathogenic bacteria, has been widely used in livestock and poultry breeding, such as broiler chickens and piglets, as a new type of feed additive. The antibacterial mechanism, structural modification, high yield strain breeding and fermentation optimization of avilamycin were briefly reviewed and the gene clusters, synthetic pathways and transcriptional regulation mechanisms of avilamycin were highlighted, based on research progress in the past five years, in this work. Further, the strategies of genetic engineering to improve the yield of avilamycin were discussed, which could provide some references for the efficient synthesis of avilamycin and the construction of industrial high-yielding engineered strains.

Key words： Avilamycin Synthetic pathway Synthesis regulation mechanism Strategies to increase production

Received: 11 September 2020 Published: 09 February 2021

ZTFLH:

Q819

Corresponding Authors: Guang-hai YU E-mail: guanghaiyu66@haut.edu.cn

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	YU Guang-hai
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	WANG Ao-yu

Cite this article:

YU Guang-hai, PENG Hai-fen, WANG Ao-yu. Research Progress of Avilamycin Biosynthesis. China Biotechnology, 2021, 41(1): 94-102.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2009022 OR https://manu60.magtech.com.cn/biotech/Y2021/V41/I1/94

Fig.1 Diagram of molecular structure of avilamycin^[15]

Fig.2 Mechanism of action of avilamycin^[18]

Table 1 Functions of partial genes in avilamycin biosynthetic gene cluster

Fig.3 Avilamycin biosynthetic gene cluster^[8]

Fig.4 Speculated avilamycin A biosynthetic pathway^[8]


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