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中国生物工程杂志

China Biotechnology
China Biotechnology  2020, Vol. 40 Issue (1-2): 1-20    DOI: 10.13523/j.cb.2002101
Orginal Article     
Current Status of Research on Coronavirus
Clarivate Analytics
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Abstract  

The outbreak of COVID-2019 has attracted the attention of the international community. This comprehensive review summarizes the research progress of the diagnosis, prevention and treatment of coronaviruses including SARS-CoV and MERS-CoV, which were extracted and compiled from the Cortellis report DISEASE BRIEFING: CORONAVIRUSES (published on January 30th, 2020), in order to provide reference for the scientific research of current epidemic situation.



Published: 27 March 2020
Cite this article:

Clarivate Analytics. Current Status of Research on Coronavirus. China Biotechnology, 2020, 40(1-2): 1-20.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2002101     OR     https://manu60.magtech.com.cn/biotech/Y2020/V40/I1-2/1

Fig.1 Digitally colorized transmission electron microscope (TEM)image Source: Centers for Disease Control and Prevention (CDC)/Dr. Fred Murphy; Sylvia Whitfield
科/特征 病毒 疾病
正粘液病毒(正粘液病毒科)单链RNA,有包膜(复制无DNA步骤;负义基因组;分段基因组) 甲型和乙型流感病毒 上呼吸道感染
义膜性喉炎
副液粘病毒(副粘液病毒科)单链RNA,有包膜(复制无DNA步骤;负义基因组;非分段基因组) 副流感病毒1-3 上呼吸道感染、义膜性喉炎
呼吸道合胞病毒 上呼吸道感染、义膜性喉炎
麻疹病毒 麻疹
腮腺炎 无菌性脑膜炎
冠状病毒(冠状病毒科)单链RNA,有包膜(复制无DNA步骤;正义基因组) 人冠状病毒 上呼吸道感染
弹状病毒科(Rhabdoviridae)单链RNA,有包膜(复制无DNA步骤;负义基因组;非分段基因组) 狂犬病病毒 狂犬病
小核糖核酸病毒(小核糖核酸病毒科)单链RNA,无包膜 鼻病毒 普通感冒
甲型肝炎病毒 肝炎
肠道病毒: 瘫痪
脊髓灰质炎病毒 急性出血性结膜炎
柯萨奇A24病毒 心肌炎、心包炎
柯萨奇B病毒 无菌性脑膜炎
柯萨奇B1-5病毒 无菌性脑膜炎
柯萨奇A9病毒 无菌性脑膜炎、脑炎
埃可病毒
杯状病毒(蚌状瘸毒科)单链RNA,无包膜 诺瓦克病毒 胃肠炎
肝炎病毒(Hepeviridae)单链RNA,无包膜 戊型肝炎 肝炎
披膜病毒(披膜病毒科)单链RNA,有包膜(复制无DNA步骤;正义基因组) 甲病毒(A组虫媒病毒) 脑炎、出血热、基孔肯雅风疹
风疹病毒
黄病毒(黄病毒科)单链RNA,有包膜(复制无DNA步骤;正义基因组) B组虫媒病毒 脑炎、出血热
丙型肝炎病毒 肝炎
登革热病毒 登革热
寨卡病毒 寨卡
布尼亚病毒(布尼亚病毒科)单链RNA,有包膜(复制无DNA步骤;负义基因组;分段基因组) 一些虫媒病毒 脑炎、出血热
汉坦病毒 发热、肾脏受损
呼肠孤病毒(呼肠孤病毒科)双链RNA,无包膜 人轮状病毒 胃肠炎
沙粒病毒(沙粒病毒科)单链RNA,有包膜(复制无DNA步骤;负链基因组;分段基因组) 淋巴细胞性脉络丛脑膜炎 脑膜炎
LCM病毒
拉沙病毒 出血热
逆转录病毒(逆转录病毒科)单链RNA,包膜(DNA复制步骤) HTLV-I、HTLV-II T细胞白血病、淋巴瘤、轻瘫
HIV-1、HIV-2 艾滋病
丝状病毒(丝状病毒科)单链RNA,有包膜(复制无DNA步骤;负链基因组;非分段基因组) 马尔堡病毒 马尔堡病
埃博拉病毒 埃博拉出血热
Table 1 List of important RNA viruses
药物名称 公司 适应症 技术类型
INO-4800 GeneOne Life Science Inc; Inovio Pharmaceuticals Inc COVID-19: 发现阶段 寡核苷酸
mRNA vaccine ModeRNA Therapeutics COVID-19: 发现阶段 单克隆抗体
BVRS-GamVac Gamalei Institute of Epidemiology and Microbiology MERS: 临床II期 重组蛋白
BVRS-GamVac-Combi 加玛雷流行病学和微生物学研究所 MERS: 临床II期 重组蛋白
GLS-5300 (INO-4700) GeneOne Life Science; Inovio Pharmaceuticals MERS: 临床 I/II 期 DNA 疫苗
MVA-MERS-S Ludwig-Maximilians-Univ. Muenchen MERS: 临床 I 期 重组蛋白
MERS-Cov vaccine The Jenner Institute MERS: 临床 I 期 重组蛋白
ChAdOx1 MERS University of Oxford; Vaccitech Ltd. MERS: 临床 I 期 重组蛋白
MVA-MERS-S_DF1 汉堡埃彭多夫大学医院 MERS: 临床前 重组蛋白
IR-101C (RespiResponse) Immune Response BioPharma SARS: 临床前 灭活疫苗
GREVAX/MERS Greffex MERS: 临床前 重组蛋白
SARS Vaccine (VEE vector) AlphaVax Inc SARS: 临床前 重组蛋白
MERS-Corona virus vaccine Themis Bioscience GmbH MERS: 临床前 重组蛋白
MERS-Cov vaccine 智飞生物; 中科院微生物所 MERS: 临床前 生物疗法
MERS-CoV vaccine 美国国家过敏和传染病研究所 MERS: 临床前 单克隆抗体
Enveloped virus vaccine 科罗拉多大学 SARS: 发现阶段 生物疗法
GreMERSfi Greffex Inc MERS: 发现阶段 重组蛋白
Recombinant coronavirus vaccine IBAkteria Sp z oo 冠状病毒: 发现阶段 重组蛋白
SARS vaccine Genecure LLC SARS: 发现阶段 重组蛋白
SARS vaccine Protein Potential LLC SARS: 发现阶段 寡核苷酸
Universal influenza vaccine 科罗拉多大学 SARS: 发现阶段 免疫球蛋白G
Table 2 Details of coronavirus vaccines under development
药物 研究结果
巴韦林、洛匹那韦和I型IFN 在组织培养中具有潜在的抗病毒作用,但无确凿临床数据
利巴韦林 26项试验未得出结论,4项研究可能存在潜在危害
类固醇 25项研究未得出结论,4项表明可能存在潜在危害
恢复期血浆、IVIG、I型IFN和洛匹那韦/利托那韦 未得到明确结论
Table 3 Research results of drug treatment for SARS infection
药物名称 公司/机构 作用机制 适应症 技术类型
瑞德西韦Remdesivir 吉利德科学 RNA依赖的RNA聚合酶抑制剂 2019-nCoV:临床III期
MERS/SARS: 临床前
Ebola: 临床II/III期
小分子
洛匹那韦/利托那韦Lopinavir/ritonavir 华中科技大学同济医学院附属同济医院 HIV-1 蛋白酶抑制剂 2019-nCoV: 临床III期 小分子
地瑞拉韦/可比司他 Darunavir/cobicistat 上海市公共卫生临床中心 HIV蛋白酶抑制剂/细胞色素P450 CYP3A4 抑制剂 2019-nCoV: 临床 小分子
奥司他韦磷酸盐Oseltamivir phosphate 华中科技大学同济医学院附属同济医院 唾液酸苷酶抑制剂(流感病毒)抑制剂 2019-nCoV: 临床 小分子
盐酸阿比多尔Umifenovir hydrochloride 华中科技大学同济医学院附属同济医院 病毒进入抑制剂/衣壳组装(乙型肝炎病毒)调节剂 2019-nCoV: 临床 小分子
抗MERS病毒康复期血浆疗法 阿卜杜拉国王国际医学研究中心 N/A Ebola:临床II/III期 (未达到终点)
MERS: 临床 II期 (试验停止)
恢复期患者血浆输注
REGN-3048-3051 再生元 抗突蛋白(MERS病毒) MERS: 临床I期 多抗体疗法
REGN-3048 再生元 抗突蛋白(MERS病毒) MERS: 临床I期 单克隆抗体
REGN-3051 再生元 抗突蛋白(MERS病毒) MERS: 临床I期 单克隆抗体
SAB-301 SAB Biotherapeutics 抗突蛋白(MERS病毒) MERS: 临床I期 多克隆抗体
LCA-60 Humabs BioMed 抗突蛋白(MERS病毒) MERS: 临床前 单克隆抗体
人白细胞干扰素 alpha AIM ImmunoTech N/A MERS: 临床前 多肽
nafamostat 东京大学 丝氨酸蛋白酶抑制剂 MERS: 临床前 重组蛋白
AM-1 国立中兴大学;爱荷华大学 核蛋白抑制剂 MERS: 临床前 小分子
DEF-201 Defyrus Inc; H&P Labs Inc 干扰素alpha配体 SARS: 临床前 重组蛋白
LB-2 Global BioLife Inc N/A SARS/MERS: 临床前 生物疗法
抗病毒孔蛋白疗法 Biotron Ltd N/A 冠状病毒感染: 药物发现 小分子
DPP4-Fc Planet Biotechnology Inc 二肽基肽酶IV调节剂 MERS: 药物发现 融合蛋白
MERS-CoV therapeutics NanoViricides Inc N/A MERS: 药物发现 重组蛋白
ranpirnase Tamir Biotechnology Inc 核糖核酸酶刺激剂 SARS; MERS: 药物发现 小分子
repurposed therapeutics Signia Therapeutics N/A MERS: 药物发现 抗体
rintatolimod AIM ImmunoTech Inc 2,5-寡腺苷酸合成酶刺激剂; 干扰素1型受体激动剂; 核糖核酸酶刺激剂; TLR-3激动剂 SARS: 药物发现 单克隆抗体
CYNK-001 Sorrento Therapeutics Inc; Celularity Inc N/A 2019-nCoV: 药物发现 细胞疗法
Table 4 Current pipelines of the medicines of anti-coronavirus
Fig.2 SARS-CoV Infection Targetscape Note:An arrow indicates a positive effect; a dash indicates a negative effect. Gray or lighter symbols are protein targets that are not validated (i.e., not under active development [UAD]). Pink text boxes with red borders indicate validated gene targets. Yellow text boxes are gene targets not UAD. Purple and pink text boxes indicate extracellular and intracellular effects, respectively. Green text boxes indicate a related disease/condition/symptom
Fig.3 MERS-CoV Infection Targetscape Note:An arrow indicates a positive effect; a dash indicates a negative effect. Gray or lighter symbols are protein targets that are not validated (i.e., not under active development [UAD]). Pink text boxes with red borders indicate validated gene targets. Yellow text boxes are gene targets not UAD. Purple and pink text boxes indicate extracellular and intracellular effects, respectively. Green text boxes indicate a related disease/condition/sympto
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