sRNA调控细菌耐药相关基因表达研究进展 <sup>*</sup>

doi:10.13523/j.cb.20180712

中国生物工程杂志

2018, Vol. 38

Issue (7): 89-93 DOI: 10.13523/j.cb.20180712

综述

sRNA调控细菌耐药相关基因表达研究进展 ^*

叶中杨¹,邱怀雨³,祝丙华¹,李泽¹,祝业^2,^**(

),王立贵^1,^**(

)

1 中国人民解放军疾病预防控制所北京 100071
2 军事科学院图书馆北京 100850
3 首都医科大学附属北京朝阳医院北京 100020

Research Progress of sRNA Regulates the Expression of Genes in Related with Bacterial Resistance

Zhong-yang YE¹,Huai-yu QIU³,Bing-hua ZHU¹,Ze LI¹,Ye ZHU^2,^**(

),Li-gui WANG^1,^**(

)

1 Institute of Disease Control and Prevention of Chinese People’s Liberation Army, Beijing 100071,China;
2 Library ofAcademy of Military Sciences, Beijing 100850, China
3 Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020,China

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摘要：

近年来随着抗菌药物的广泛应用,造成各种耐药菌、多重耐药菌甚至是超级细菌的出现,对抗菌治疗产生严重的威胁。sRNA是一类新发现的基因表达调控因子,通过与靶mRNA或靶蛋白配对,从而调控细胞的生理功能以应对各种环境变化。研究表明,sRNA能够在细菌耐药过程中(如阻碍抗生素进入细胞、将药物外排出菌胞)发挥重要的调控作用。就sRNA参与调控细菌耐药机制相关基因的表达研究展开系统综述,从而为阐明耐药机制及发现新的药物靶点提供有益参考。

关键词： sRNA; 细菌耐药; 耐药机制

Abstract:

In recent years, the emergence of drug-resistant bacteria poses a serious threat to the antibiotic therapy. sRNAs are new regulatory factors of gene expression, which regulate the physiological function of cell in response to various environmental changes by pairing target mRNA or protein. Studies have shown that sRNA can play an important role in the process of bacterial resistance, such as blocking the pathways of antibiotics into cells and releasing the drugs in the cells. The sRNAs regulates the expression of genes in related with bacterial resistance, which is helpful for elucidation of resistance mechanisms and discovery of new drug targets were reviewed.

Key words: sRNA Bacterial resistance Resistance mechanism

收稿日期: 2018-02-27 出版日期: 2018-08-13

ZTFLH:

Q819

基金资助: 军医学科技青年培育计划(16QNP127);北京市科技新星计划(Z171100001117102)

通讯作者: 祝业,王立贵 E-mail: zhuye10079@sina.com;wangligui1983@126.com

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引用本文:

叶中杨,邱怀雨,祝丙华,李泽,祝业,王立贵. sRNA调控细菌耐药相关基因表达研究进展 ^*[J]. 中国生物工程杂志, 2018, 38(7): 89-93.

Zhong-yang YE,Huai-yu QIU,Bing-hua ZHU,Ze LI,Ye ZHU,Li-gui WANG. Research Progress of sRNA Regulates the Expression of Genes in Related with Bacterial Resistance. China Biotechnology, 2018, 38(7): 89-93.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20180712 或 https://manu60.magtech.com.cn/biotech/CN/Y2018/V38/I7/89

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