CD127是IL-7受体α链，T淋巴细胞对IL-7的特异性应答主要通过CD127的表达实现的。CD127在胸腺细胞向T淋巴细胞的发育过程、成熟T细胞内环境稳态的维持、病毒感染后T细胞的免疫应答及记忆性T细胞的分化及幸存等方面发挥重要的作用。在整个T淋巴细胞生命周期中仅有两个阶段缺乏CD127的表达：即双阳性CD4+CD8+T细胞及激活的T细胞。近期，随着对CD127研究的不断深入，发现CD127在作为记忆性T细胞及调节性T细胞特异性的表面标记物方面也发挥着重要作用。本文简要介绍了CD127在T淋巴细胞生命周期的不同阶段所发挥的调节作用及其机制。
CD127 is the interleukin-7 receptor α (IL-7Rα), it regulates the specific respond of T lymphocytes to IL-7. CD127 plays an indispensable role in the development of thymocytes into T lymphocytes, the survival and homeostatic proliferation of memory T cells. There are only two phases of the life period of T cells that do not express CD127: immature CD4+8+double positive (DP) thymocytes and activated T cells. Recently, CD127 was found that it play an important role as the specific marker of memory T cells and regulator T cells. The role and mechanism of CD127 in the life period of T cells were discussed herein
孙晨鸣,马海霞,刘光伟,赵勇. CD127与T淋巴细胞[J]. 中国生物工程杂志, 2007, 27(5): 113-119.
. CD127 and T lymphocytes. China Biotechnology, 2007, 27(5): 113-119.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2007/V27/I5/113
Cited
