研究报告 |
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凋亡素蛋白多克隆抗体的制备及免疫学评价 |
王春晖1, 王剑松1, 王文举2, 詹辉1, 李鸿钧2, 颜汝平1, 徐鸿毅1 |
1. 昆明医学院第二附属医院泌尿外科 云南省泌尿外科研究所 昆明 650101;
2. 中国医学科学院/北京协和医学院医学生物学研究所 昆明 650118 |
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Preparation and Evaluation of Polyclonal Antibodies of Apoptin |
WANG Chun-hui1, WANG Jian-song1, WANG Wen-ju2, ZHAN Hui1, LI Hong-jun2, YAN Ru-ping1, XU Hong-yi1 |
1. Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China;
2. Institute of Medical Biology, Chinese Academy of Medical Science ﹠ Peking Union Medical School, Kunming 650118, China |
引用本文:
王春晖, 王剑松, 王文举, 詹辉, 李鸿钧, 颜汝平, 徐鸿毅. 凋亡素蛋白多克隆抗体的制备及免疫学评价[J]. 中国生物工程杂志, 2011, 31(7): 38-44.
WANG Chun-hui, WANG Jian-song, WANG Wen-ju, ZHAN Hui, LI Hong-jun, YAN Ru-ping, XU Hong-yi. Preparation and Evaluation of Polyclonal Antibodies of Apoptin. China Biotechnology, 2011, 31(7): 38-44.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/
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https://manu60.magtech.com.cn/biotech/CN/Y2011/V31/I7/38
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[1] Noteborn M H. Apoptin acts as a tumor-specific killer: potentials for an anti-tumor therapy. Cell Mol Biol (Noisy-le-grand), 2005, 51(1):49-60.
[2] Backendorf C, Visser A E, de Boer A G, et al. Apoptin: therapeutic potential of an early sensor of carcinogenic transformation. Annu Rev Pharmacol Toxicol, 2008, 48(2): 143-169.
[3] Rohn J L, Noteborn M H. The viral death effector Apoptin reveals tumor-specific processes. Apoptosis, 2004, 9(3): 315-322.
[4] 王文举, 孙茂盛, 严敏, 等. Neurturin嵌合神经营养因子重组腺病毒的构建及体外活性测定. 中国生物工程杂志, 2010, 30(9): 7-12. Wang W J, Sun M S, Yan M, et al. China Biotechnology, 2010, 30(9): 7-12.
[5] Schoop R A, Kooistra K, Baatenburg De Jong R J, et al. Bcl-xL inhibits p53-but not apoptin-induced apoptosis in head and neck squamous cell carcinoma cell line. Int J Cancer, 2004, 109(1): 38-42.
[6] Noteborn M H. Chicken anemia virus induced apoptosis: underlying molecular mechanisms. Vet Microbiol, 2004, 98(2):89-94.
[7] Danen-Van Oorschot A A, Zhang Y H, Leliveld S R, et al. Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis. J Biol Chem, 2003, 278(30): 27729-27736.
[8] Rohn J L, Zhang Y H, Aalbers R I, et al. A tumor-specific kinase activity regulates the viral death protein Apoptin. J Biol Chem, 2002, 277(52): 50820-50827.
[9] Leliveld S R, Dame R T, Mommaas M A, et al. Apoptin protein multimers form distinct higher-order nucleoprotein complexes with DNA. Nucleic Acid Res, 2003, 31(16): 4805-4813.
[10] Leliveld S R, Dame R T, Rohn J L, et al. Apoptins functional N-and C-termini independently bind DNA. FEBS Lett, 2004, 557(1-3): 155-158.
[11] Liu X, Zeidan Y H, Elojeimy S, et al. Involvement of sphingolipids in apoptin-induced cell killing. Mol Ther, 2006, 14(5):627-636.
[12] Wadia J S, Wagner M V, Ezhevsky S A, et al. Apoptin/VP3 contains a concentration-dependent nuclear localization signal(NLS), not a tumorigenic selective NLS. J Virol, 2004, 78(11): 6077-6078.
[13] 王春晖, 王剑松, 詹辉, 等. 改良型TAT-凋亡素体外抗人膀胱肿瘤活性的研究. 中国肿瘤临床, 2011, 38(5): 246-249. Wang C H, Wang J S, Zhan H, et al. Chinese Journal of Clinical Oncology, 2011, 38(5): 246-249.
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