逆转录病毒载体在基因工程疫苗方面的应用

doi:Q782

中国生物工程杂志

2010, Vol. 30

Issue (06): 130-133 DOI: Q782

综述

逆转录病毒载体在基因工程疫苗方面的应用

张继文,杨桂连^**,王春凤^**

吉林农业大学动物科学技术学院长春 130118

The Use of Retroviral Vector in Genetically Engineering Vaccine

ZHANG Ji-wen,YANG Gui-lian,WANG Chun-feng

College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China

全文: PDF(379 KB) HTML

摘要：

逆转录病毒载体是根据逆转录病毒的特性设计出的一种病毒表达载体，以其能够整合到宿主细胞染色体上并能稳定表达目的基因而被视为基因运载最有效的工具。目前广泛应用于基因治疗、外源基因表达、基因工程疫苗等方面。主要综述了逆转录病毒载体在基因工程疫苗方面的应用现状及前景，为该载体在生物医学领域方面的应用提供有价值的参考。

关键词： 逆转录病毒载体; 基因工程亚单位疫苗; DNA疫苗

Abstract:

Retroviral vector was a virus expression vector which was designed by some characteristics of retrovirus. Because it can integrate into the chromosome of host cells and stably express the interesting gene. It was considered as the most efficient means of delivering a interest gene into human cells. Presently, retroviral vector was extensively used for gene therapy, exogenous gene expression and genetically engineering vaccine. The use of retroviral expression vector in genetically engineering vaccine and its applied perspect were mainly discussed,which provide valuable reference for the application of biomedicine.

Key words: Retroviral vector Genetically engineering subunit vaccine DNA vaccine

收稿日期: 2010-02-24 出版日期: 2010-06-12

基金资助:

国家“863”计划（2007AA10Z322，2006AA10A205）资助项目

通讯作者: 王春凤 E-mail: wangchunfeng@jlau.edu.cn;yangguilian@jlau.edu.cn

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引用本文:

张继文杨桂连王春凤. 逆转录病毒载体在基因工程疫苗方面的应用[J]. 中国生物工程杂志, 2010, 30(06): 130-133.

ZHANG Ji-Wen, YANG Gui-Lian, WANG Chun-Feng. The Use of Retroviral Vector in Genetically Engineering Vaccine. China Biotechnology, 2010, 30(06): 130-133.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/Q782 或 https://manu60.magtech.com.cn/biotech/CN/Y2010/V30/I06/130

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