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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2010, Vol. 30 Issue (05): 140-148    
综述     
酵母细胞甘油代谢与生理功能研究进展
陈献忠1,2,王正祥1,2,诸葛健1
1.江南大学工业生物技术教育部重点实验室 无锡 2141222
2.江南大学生物工程学院 生物资源与生物能源研究中心 无锡 214122
Progress in Glycerol Metabolism and its Physiological Function in Yeast Cells
CHEN Xian-zhong1,2,WANG Zheng-xiang1,2,ZHU Ge-jian1
1.Key Lab of Industrial Biotechnology, The Education Ministry, Jiangnan University, Wuxi 214122, China
2.Center for Bioresource & Bioenergy, School of Biotechnology, Jiangnan University, Wuxi 214122, China
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摘要：

甘油是酵母细胞生长代谢过程中常见的多元醇物质。尽管甘油的结构简单，代谢途径并不复杂，但是其在细胞内的生理功能十分重要。甘油代谢过程主要参与细胞的高渗透压生理调节和厌氧条件下的胞内氧化还原平衡调节。近年来许多学者在酵母细胞的甘油代谢及生理功能方面开展了深入的研究。在扼要介绍甘油生理代谢的基础上，重点阐述甘油代谢参与细胞高渗压甘油应答信号途径和氧化还原平衡调节的生理机制，同时就酵母细胞甘油合成的代谢工程进行归纳和评述。
关键词： 酵母细胞;  甘油代谢;  高渗压甘油途径;  氧化还原平衡    
Abstract:

Glycerol, a common polyol metabolite, is produced during yeast cells growth, propagation and glucose metabolism. Though glycerol structure and metabolic pathway is very simple, it plays an important physiological role in yeast cells, especially which are exposed in such stress conditions as hypertonic medium, frozen temperature and anaerobic environment. Glycerol metabolism is involved in osmoregulation and redox balance regulation. Recently, physiological function of glycerol in yeast, especially for Saccharomyces cerevisiae, were focused on and investigated widely. Glycerol metabolism was introduced succinctly, and the correlations of glycerol production and osmoregulation, redox balance are emphasized on. Moreover, metabolic engineering for glycerol biosynthesis and its future research prospects are discussed.
Key words: Saccharomyces cerevisiae    Glycerol metabolism    High osmotic glycerol pathway    Redox balance
收稿日期: 2009-12-16 出版日期: 2010-05-25
通讯作者: 陈献忠     E-mail: zxwang@jiangnan.edu.cn
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陈献忠 王正祥 诸葛健. 酵母细胞甘油代谢与生理功能研究进展[J]. 中国生物工程杂志, 2010, 30(05): 140-148.

CHEN Xian-Zhong, WANG Zheng-Xiang, CHU Ge-Jian. Progress in Glycerol Metabolism and its Physiological Function in Yeast Cells. China Biotechnology, 2010, 30(05): 140-148.

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https://manu60.magtech.com.cn/biotech/CN/    或    https://manu60.magtech.com.cn/biotech/CN/Y2010/V30/I05/140

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