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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志  2011, Vol. 31 Issue (01): 75-80    
综述     
成纤维细胞生长因子8(FGF8)研究进展
王一1,2, 田海山1,2, 李校堃1,2
1. 吉林农业大学生物反应器与药物开发教育部工程研究中心 长春 130118;
2. 吉林农业大学生命科学学院 长春 130118
The Development of Fibroblast Growth Factor 8
WANG Yi1,2, TIAN Hai-shan1,2, LI Xiao-kun1,2
1. Bioreactor with the Drug Development Project of the Ministry of Education Research Center, Jilin Agricultural Uniersity, Changchun 130118, China;
2. The School of Life Science, Jilin Agricultural University, Changchun 130118, China
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摘要:

成纤维细胞生长因子8(fibroblast growth factor 8,FGF8)是成纤维细胞生长因子(FGFs)家族的成员之一。其在人胚胎时期多种组织内进行表达,对各种器官的形成中起着重要的作用。在正常成人体内,FGF8的表达水平受到严格的限制,然而在某些癌细胞或炎症部位中大量表达,特别是在激素类癌症的发生和发展中起着重要的作用。因此应用FGF8抗体治疗激素类癌症,为临床提供了新的治疗途径。

关键词: 成纤维细胞生长因子8胚胎发育激素依赖性癌症FGF8抗体生物学活性    
Abstract:

Fibroblast growth factor-8 (fibroblast Growth Factor 8, FGF8) is one of the fibroblast growth factor (FGFs) family members. FGF8 is expressed in a lot of organizations in human embryo. And it is an important role in the formation of many organizations.the expression of FGF8 is strictly restricted in normal adult body. But FGF8 is over expressed in some kind of inflammatory cells, and especially in hormone-dependent cancers. It also plays an important role in the occurrence and development of hormone-dependent cancers. Application of FGF8 antibody in hormone-dependent cancer is an inevitable trend in clinical treatment.

Key words: Fibroblast growth factor 8    Embryo development    Hormone-dependent cancers    FGF8 antibody    Biological activity
收稿日期: 2010-08-24 出版日期: 2011-01-25
ZTFLH:  Q344+.13  
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引用本文:

王一, 田海山, 李校堃. 成纤维细胞生长因子8(FGF8)研究进展[J]. 中国生物工程杂志, 2011, 31(01): 75-80.

WANG Yi, TIAN Hai-shan, LI Xiao-kun. The Development of Fibroblast Growth Factor 8. China Biotechnology, 2011, 31(01): 75-80.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/        https://manu60.magtech.com.cn/biotech/CN/Y2011/V31/I01/75


[1] Tanaka A, Miyamoto K, Minamino N, et al. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc Natl Acad Sci USA,1992,89(19):8928-8932.

[2] Payson R A, Jackson W, Liu Y, et al. The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells. Oncogene,1996,13(1):47-53.

[3] Gemel J, Gorry M, Ehrlich G D, et al. Structure and sequence of human FGF8. Genomics,1996,35(5):253-257.

[4] Olsen S K, Li J Y, Bromleighc, et al. Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes & Dev,2006,20(2): 185-198.

[5] Ornitz D M, Xu J, Colvin J S, et al. Receptor specificity of the fibroblast growth factor family. BiolChem,1996,271(25):15292-15297.

[6] Blunt A G, Lawshe A, Cunningham M L, et al. Overlapping expression and redundant activation of mesenchymal fibroblast growth factor(FGF)receptors by alternatively spliced FGF-8 ligands. Biol Chem,1997, 272(6):3733-3738.

[7] Mott N N, Chung W C,Tsai P S, et al. Differential fibroblast growth factor 8(FGF8)-mediated autoregulation of Its cognate receptors, Fgfr1 and Fgfr3, in Neuronal Cell Lines PLoS ONE,2010, 5(4): e10143.

[8] Viklund L, Vorontsova N, Henttinen T, et al. Syndecan-1 regulates FGF8b responses in S115 mammary carcinoma cells. Growth Factors,2006,24(2):151-157.

[9] Ralph T,Bottcher, Christof N.Fibroblast growth factor signaling during early vertebrate development.Endocrine Reviews ,2005,26 (1), 63-77.

[10] Crossley P H, Martin G R. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development,1995,121(2),439-451.

[11] Sun X, Meyers E N, Lewandoski M, et al. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev,1999, 13(14):1834-1846.

[12] Ohuchi H, Yoshioka H, Tanaka A, et al. Involvement of androgen-induced growth factor(FGF-8)gene in mouse embryogenesis and morphogenesis. Biochem Biophys ResCommun,1994,204(2):882-888.

[13] Heikinheimo M, Lawshe A, Shackleford G M, et al. Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev,1994, 48(2):129-138.

[14] Haraguchi R, Suzuki K, Murakami R, et al. Molecular analysis of external genitalia formation:the role of fibroblast growth factor(Fgf)genes during genital tubercle formation. Development,2000, 127(11):2471-2479.

[15] Crossley P H, Minowada G, MacArthur C A, et al. Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell ,1996,84(1):127-136.

[16] Crossley P H, Martinez S, Martin G R. Midbrain development induced by FGF8 in the chick embryo. Nature,1996,380(6569):66-68.

[17] Elaine E. Storm, John L R. Rubenstein and Gail R. Martin. Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. PNAS,2003,100(4): 1757-1762.

[18] Wassef M,Joyner A L. Early mesencephalon/metencephalon patterning and development of the cerebellum. Perspect. Dev. Neurobiol,1997,5(1):3-16.

[19] Shanmugalingam S,Houart C,Picker A, et al. Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon. Development,2000,127(12):2549-2561.

[20] Gimeno L,Martinez S. Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh. Developmental Dynamics,2007, 236(8): 2285-2297.

[21] Schneider R A, Hu D, Rubenstein J L, et al. Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH. Development,2001,128(4):2755-2767.

[22] Makoto A, Takashi M, Satoshi W. Retinoic acid affects craniofacial patterning by changing Fgf8 expression in the pharyngeal ectoderm. Development, Growth & Differentiation,2008,50(9) 717-729.

[23] Shimako K, Jianyong S, Rosaysela S, et al. Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development,2005, 132(23):5211-5223.

[24] Elena D F, Victor V, Yolanda A, et al. Tissue-specific requirements for FGF8 during early inner ear development. Mechanisms of Development,2009,126(10): 873-881.

[25] Lewandoski M, Sun X, Martin GR. Fgf8 signalling from the AER is essential for normal limb development. Nat Genet,2000,26(4):460-463.

[26] Rocio H M, Susana C O, Luis C. Fgf8 and retinoic acid control the initiation of interdigital cell death without the direct participation of Bmp7 in the mouse limb. Developmental Biology,2007,306(1): 447-448.

[27] Ilagan R, Abu-Issa R, Brown D, et al. Fgf8 is required for anterior heart field development. Development,2006,133(12):2435-2445.

[28] Sirbu I O, Zhao X, Duester G. Retinoic acid controls heart anteroposterior patterning by downregulating Isl1 through the fgf8 pathway. Dev Dyn,2008, 237(6): 1627-1635.

[29] Serls A E, Doherty S, Parvatiyar P, et al. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development,2005,132(1):35-47.

[30] Perantoni A O, Timofeeva O, Naillat F, et al. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development, 2005, 132(17):3859-3871.

[31] Marsh S K, Bansal G S, Zammit C, et al. Increased expression of fibroblast growth factor 8 in human breast cancer. Oncogene, 1999, 18(4):1053-1060.

[32] Ghosh A, Shankar D B, Shackleford G M, et al. Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. Cell Growth Differ, 1996, 7(10):1425-1434.

[33] Tanaka A, Furuya A, Yamasaki M, et al. High frequency of fibroblast growth factor(FGF)8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF8. Cancer Res, 1998, 58(10):2053-2056.

[34] Valve E, Penttila T L, Paranko J, et al. FGF-8 is expressed during specific phases of rodent oocyte and spermatogonium development . Biochem Biophys Res Commun, 1997, 232(1):173-177.

[35] Nezu M, Tomonaga T, Sakai C, et al. Expression of the fetal-oncogenic fibroblast growth factor-8/17/18 subfamily in human hematopoietic tumors. Biochem Biophys Res Commun, 2005, 335(3):843-849.

[36] Valta M P, Hentunen T, Qu Q, et al. Regulation of osteoblast differentiation:a novel function for fibroblast growth factor-8. Endocrinology,2006,147(5):2171-2182.

[37] Dorkin T J, Robinson M C, Marsh C, et al. aFGF immunoreactivity in prostate cancer and its co-localization with bFGF and FGF8. J Pathol , 1999, 189(4):564-569.

[38] Kwabi-Addo B, Ozen M, Ittmann M. The role of fibroblast growth factors and their receptors in prostate cancer. Endocr Relat Cancer, 2004, 11(4) :709-724.

[39] Tanaka A, Kamiakito T, Takayashiki N, et al. Fibroblast growth factor 8 expression in breast carcinoma:associations with androgen receptor and prostate-specific antigen expressions. Virchows Arch, 2002, 441(4):380-384.

[40] Somboonporn W, Davis S R. Testosterone effects on the breast:implications for testosterone therapy for women. Endocr Rev, 2004, 25(3):374-388.

[41] Valve E, Martikainen P, Seppanen J, Oksjoki S, et al. Expression of fibroblast growth factor(FGF)-8 isoforms and FGF receptors in human ovarian tumors. Int J Cancer , 2000, 88(5):718-725.

[42] Kouhara H, Koga M, Kasayama S, et al. Transforming activity of a newly cloned androgen-induced growth factor. Oncogene , 1994, 9(2):455-462.

[43] Daphna-Iken D, Shankar D B, Lawshe A, et al. MMTV-Fgf8 transgenic mice develop mammary and salivary gland neoplasia and ovarian stromal hyperplasia. Oncogene, 1998, 17(21):2711-2717.

[44] Zhong C, Saribekyan G, Liao C, et al. Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis. Cancer Res , 2006, 66(4):2188-2194.

[45] Song Z, Wu X, Powell W C, et al. Fibroblast growth factor 8 isoform b overexpression in prostate epithelium:a new mouse model for prostatic intraepithelial neoplasia. Cancer Res, 2002, 62(17):5096-5105.

[46] Rudra-Ganguly N, Zheng J, Hoang A T, et al. Downregulation of FGF8 activity by antisense constructs in murine fibroblastic and human prostatic carcinoma cell systems. Oncogene, 1998, 16(11):1487-1492.

[47] Ruohola J K, Viitanen T P, Valve E M, et al. Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells. Cancer Res, 2001, 61(10):4229-4237.

[48] Mattila M M, Ruohola J K, Valve E M, et al. FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells. Oncogene, 2001, 20(22):2791-2804.

[49] Song Z, Powell W C, Kasahara N, et al. The effect of fibroblast growth factor 8, isoform b, on the biology of prostate carcinoma cells and their interaction with stromal cells. Cancer Res, 2000, 60(23):6730-6736.

[50] Ornitz D M. FGF signaling in the developing endochondral skeleton. Cytokine Growth Factor Rev, 2005, 16(2):205-213.

[51] Masako U, Tadafumi T, Toshio S, et al. Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis. Arthritis Research & Therapy, 2008, 10(4): R90.

[52] Maruyama-Takahashi K, Shimada N, Imada T, et al. A neutralizing anti-fibroblast growth factor (FGF) 8 monoclonal antibody shows anti-tumor activity against FGF8b-expressing LNCaP xenografts in androgen-dependent and-independent conditions. The Prostate,2008,68(6):640-650.

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