Please wait a minute...

中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志  2010, Vol. 30 Issue (03): 119-124    
综述     
达托霉素生产工艺及其衍生物组合生物合成
刘伯宁*,仓基勇,张华
华北制药集团新药研发公司 国家微生物制药工程中心 石家庄 050015
Manufacturing Process of Daptomycin and Combinatorial Biosynthesis of Derivatives
New Drug Research and Development Center, North China Pharmaceutical Group Corporation and National Microbial Medicine Engineering and Research Center, Shijiazhuang 050015,China
 全文: PDF(702 KB)   HTML
摘要:

作为首个进入临床应用的环脂肽类抗生素,达托霉素自2003年上市以来,适应症不断增加,市场前景良好。达托霉素的制备工艺与结构修饰,已经成为了近年抗感染用药研发的一个热点。追溯了达托霉素的发现历程,生产工艺沿革。重点介绍了达托霉素的发酵工艺,合成基因簇研究进展,以及组合生物技术在达托霉素结构修饰中的应用。

关键词: 达托霉素A21978生产工艺发酵工艺组合生物合成    
Abstract:

Since the first approved lipopeptide antibiotics-datomycin launched in 2003, there were increasing indications and bright market prospects of daptomycin, resulting its manufacturing process and structure modification has become the focus of anti-infection drugs research and development.The course of leading compound A21978C and reviewed the evolution of synthetic techniques was traced. Moreover, manufacturing technology, biosynthetic gene clusters of daptomycin, and application of combinatorial biosynthesis in structure of daptomycin were also introduced emphatically.

Key words: Daptomycin    Cycle lipopeptide antibiotics    Manufacturing process    Fermentation technology    Combinatorial biosynthesis
收稿日期: 2009-05-20 出版日期: 2010-03-25
通讯作者: 刘伯宁     E-mail: liuboning801@sina.com
服务  
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章  
刘伯宁
仓基勇
张华

引用本文:

刘伯宁 仓基勇 张华. 达托霉素生产工艺及其衍生物组合生物合成[J]. 中国生物工程杂志, 2010, 30(03): 119-124.

LIU Ba-Ning, CANG Ji-Yong, ZHANG Hua. Manufacturing Process of Daptomycin and Combinatorial Biosynthesis of Derivatives. China Biotechnology, 2010, 30(03): 119-124.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/        https://manu60.magtech.com.cn/biotech/CN/Y2010/V30/I03/119

[1] 刘伯宁, 石磊,蒋沁. 环脂肽抗生素的研究进展. 中国抗生素,2007,32(9),520525. Liu B, Shi L, Jiang Q.Chinese Journal of Antibiotics,2007,32(9):520525. 
[2] Brown E D. Microbiology: Antibiotic stops ‘pingpong’ match. Nature,2006,441(7091):293294. 
[3] Guay D R. Daptomycin: The first approved lipopeptide antimicrobial. Consult Pharm,2004,19(7):614628. 
[4]Abbott B J, Debono M,Fukuda D S. A21978c cyclic peptides:United States,4524135.1985618.
[5] Debono M, Barnhart M, Carrell C B, et al. A21978c, a complex of new acidic peptide antibiotics: Isolation, chemistry, and mass spectral structure elucidation. J Antibiot (Tokyo),1987,40(6):761777. 
[6]Eaton T E, Ford L M, Godfrey J, et al. Process for producing the a21978c antibiotics:United States,4800157.1989624. 
[7]Huber F M, Pieper R L,Tietz A J. Process for producing a21978c derivatives:United States,4885243.1989125. 
[8] Lakey J H,Lea E J. The role of acyl chain character and other determinants on the bilayer activity of a21978c an acidic lipopeptide antibiotic. Biochim Biophys Acta,1986,859(2):219226. 
[9] Debono M, Abbott B J, Molloy R M, et al. Enzymatic and chemical modifications of lipopeptide antibiotic a21978c: The synthesis and evaluation of daptomycin (ly146032). J Antibiot (Tokyo),1988,41(8):10931105. 
[10]Bernard J A, Debono M,Fukuda D S. Derivatives of a21978c cyclic peptides:United States,4537717.1985827. 
[11] Boeck L D, Fukuda D S, Abbott B J, et al. Deacylation of a21978c, an acidic lipopeptide antibiotic complex, by actinoplanes utahensis. J Antibiot (Tokyo),1988,41(8):10851092. 
[12] Eliopoulos G M, Willey S, Reiszner E, et al. Invitro and invivo activity of ly146032 a new cycle lipopeptide antibiotic. Antimicrobial Agents and Chemotherapy,1986,30(4):532535. 
[13] Huber F M, Pieper R L,Tietz A J. The formation of daptomycin by supplying decanoic acid to streptomyces roseosporus cultures producing the antibiotic complex a21978c. Journal of Biotechnology,1988, 7(4):283192. 
[14]Baker P J, Debono M, Farid K Z, et al. Anhydro and isomera21978c cyclic peptides:United States,5912226,2006418. 
[15] Kirsch L E, Molloy R M, Debono M, et al. Kinetics of the aspartyl transpeptidation of daptomycin, a novel lipopeptide antibiotic. Pharmaceutical Research,1989,6(5):387393. 
[16] McHenney M A,Baltz R H. Gene transfer and transposition mutagenesis in streptomyces roseosporus: Mapping of insertions that influence daptomycin or pigment production. Microbiology,1996,142 ( Pt 9)23632373. 
[17] McHenney M A, Hosted T J, Dehoff B S, et al. Molecular cloning and physical mapping of the daptomycin gene cluster from streptomyces roseosporus. J Bacteriol,1998,180(1):143151. 
[18] Baltz R H. Molecular engineering approaches to peptide, polyketide and other antibiotics. Nat Biotechnol,2006,24(12):15331540. 
[19] Grunewald J,Marahiel M A. Chemoenzymatic and templatedirected synthesis of bioactive macrocyclic peptides. Microbiol Mol Biol Rev,2006,70(1):121146. 
[20] Miao V, CoeffetLegal M F, Brian P, et al. Daptomycin biosynthesis in streptomyces roseosporus: Cloning and analysis of the gene cluster and revision of peptide stereochemistry. Microbiology,2005,151(Pt 5):15071523. 
[21] Julia P, Xiang L, Whiting A, et al. Heterologous production of daptomycin in streptomyces lividans. Journal of Industrial Microbiology & Biotechnology,2006,33(2):121128. 
[22] Miao V, Brost R, Chapple J, et al. The lipopeptide antibiotic a54145 biosynthetic gene cluster from streptomyces fradiae. J Ind Microbiol Biotechnol,2006,33(2):129140.
 [23] Hojati Z, Milne C, Harvey B, et al. Structure, biosynthetic origin, and engineered biosynthesis of calciumdependent antibiotics from streptomyces coelicolor. Chem Biol,2002,9(11):11751187. 
[24] Nguyen K T, Ritz D, Gu J Q, et al. Combinatorial biosynthesis of novel antibiotics related to daptomycin. Proceedings of the National Academy of Sciences of the United States of America,2006,103(46):1746217467. 
[25] Baltz R H, Brian P, Miao V, et al. Combinatorial biosynthesis of lipopeptide antibiotics in streptomyces roseosporus. Journal of Industrial Microbiology & Biotechnology,2006,33(2):6674. 
[26] Miao V, CoeffetLe Gal M F, Nguyen K, et al. Genetic engineering in streptomyces roseosporus to produce hybrid lipopeptide antibiotics. Chem Biol,2006,13(3):269276. 
[27] Nguyen K T, Kau D, Gu J Q, et al. A glutamic acid 3methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in streptomyces roseosporus. Molecular Microbiology,2006,61(5):12941307. 
[28] 范晶华.达托霉素高产菌株选育与发酵条件优化.天津:天津大学,化工学院,2007. Fan J H,Study on the Breeding of High Daptomycin Producing Strains and Fermentation Conditions Optimization Tianjin :Tianjin University,School of Chemical Engineering and Technology,2007. 
[29] 王建平.达托霉素菌种诱变与发酵条件研究.天津:天津大学,化工学院,2007. Wang J P,Study on Screening of daptomycin Producing Strains and fermentation Conditions.Tianjin :Tianjin University,School of Chemical Engineering and Technology,2007. 
[30] Kim H B, Smith C P, Micklefield J, et al. Metabolic flux analysis for calcium dependent antibiotic (cda) production in streptomyces coelicolor. Metab Eng,2004,6(4):313325. 
[31] Baltz R H, Miao V,Wrigley S K. Natural products to drugs: Daptomycin and related lipopeptide antibiotics. Nat Prod Rep,2005,22(6):717741.

[1] 彭强强,刘启,徐名强,张元兴,蔡孟浩. 新型重组毕赤酵母产人胰岛素前体的表达工艺研究 *[J]. 中国生物工程杂志, 2019, 39(7): 48-55.
[2] 樊亚超,张霖,李晓姝,王鹏翔,姚新武,乔凯. Klebsiella pneumoniae CICC10011发酵产2,3-丁二醇的工艺研究[J]. 中国生物工程杂志, 2018, 38(2): 68-74.
[3] 杨恬然, 吴世杰, 辛明秀. 达托霉素作为新的胰蛋白酶激活剂的初探[J]. 中国生物工程杂志, 2017, 37(10): 26-32.
[4] 韩启灿, 霍光华, 罗桂祥. 一株病原拮抗野生菌株的筛选、鉴定及其发酵工艺优化[J]. 中国生物工程杂志, 2014, 34(5): 66-74.
[5] 武为平, 陈捷, 李雅乾, 陈立杰, 段玉玺. 响应面法优化棘孢木霉产厚垣孢子发酵工艺[J]. 中国生物工程杂志, 2013, 33(12): 97-104.
[6] 刘畅 葛锋 刘迪秋 王剑平 陈朝银. 红曲桔霉素的控制对策[J]. 中国生物工程杂志, 2009, 29(11): 117-122.
[7] 林俊涵. 毕赤酵母高密度发酵工艺的研究[J]. 中国生物工程杂志, 2009, 29(05): 120-125.
[8] 胡秀芳,应飞祥,陈集双. 胶质芽孢杆菌突变株021120的培养条件及发酵工艺优化[J]. 中国生物工程杂志, 2007, 27(9): 58-62.
[9] 刘建峰,葛向阳,梁运祥. 响应面法优化豆粕固态发酵工艺的研究[J]. 中国生物工程杂志, 2007, 27(6): 87-91.
[10] 田博,吴彬,耿越. 腺病毒载体生产工艺研究进展[J]. 中国生物工程杂志, 2006, 26(0): 223-225.
[11] 籍保平, 尤希风, 张博润. 苹果渣发酵生产饲料蛋白的工艺条件[J]. 中国生物工程杂志, 1999, 19(5): 30-33.
[12] 孙万儒. 生物技术产品的后处理工艺设计策略及有关思考[J]. 中国生物工程杂志, 1993, 13(1): 42-49.
[13] 张启先. 我国微生物多糖工业发展中的喜与忧[J]. 中国生物工程杂志, 1991, 11(6): 24-29.
[14] DietrichKnorr, 何丰. 食品生产和加工的生物工程学[J]. 中国生物工程杂志, 1986, 6(4): 46-53.
[15] 坂口博脩, StenL.knudsen, 廖纲煊. 工业用酶的发展趋势[J]. 中国生物工程杂志, 1984, 4(3): 72-82.