研究报告 |
|
|
|
|
多巴胺合成相关酶基因联合治疗帕金森病大鼠模型的研究 |
鲁玲玲,赵焕英,吴均,杨慧 |
首都医科大学北京神经科学研究所北京市神经再生修复研究重点实验室 |
|
Therapeutic benefit of TH, AADC, and GCH-I genes for Parkinson’s disease in rat model |
[1] Nagatsu T. Genes for human catecholaminesynthesizing enzymes. Neurosci Res, 1991, 12(2): 315~345
[2] Bankiewicz K S, Forsayeth J, Eberling J L, et al. Longterm clinical improvement in MPTPlesioned primates after gene therapy with AAV–hAADC. Molec Ther 2006, 14: 564~570
[3] Porras G, Bezard E. Preclinical development of gene therapy for Parkinson’s disease. Experimental Neurology, 2008, 209(1):72~81
[4] Nagatsu T, Ichinose H. Regulation of pteridinerequiring enzymes by the cofactor tetrahydrobiopterin. Mol Neurobiol, 1999, 19(1): 79~96
[5] Fiandaca M, Forsayeth J, Bankiewicz K. Current status of gene therapy trials for Parkinson’s disease. Exp Neurol, 2008, 209: 51~57
[6] Cress D E. The need for regulatable vectors for gene therapy for Parkinson’s disease. Exp Neurol, 2008, 209: 30~33
[7] Gasmi M, Herzog C D, Brandon E P, et al. Striatal delivery of neurturin by CERE120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson’s disease. Molec Ther,2007,15:62~68
[8] Hadaczek P, Kohutnicka M, Krauze M T, et al. Convectionenhanced delivery of adenoassociated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain. Hum Gene Ther, 2006,17:291~302
[9] Lu L L, Zhao C L, Liu Y J, et al. Therapeutic benefit of THengineered mesenchymal stem cells for Parkinson’s disease. Brain Research Protocols, 2005, 15(1):46~51
[10] Yang H, Wanner I B , Roper S D, et al. An optimized method for in situ hybridization with signal amplification that allows the detection of rare mRNAs J . J Histochem Cytochem, 1999 , 47 (4) :431
[11] Shen Y, Muramatsu S I, Ikeguchi K, et al. Triple transduction with adenoassociated virus vectors expressing tyrosine hydroxylase, aromaticLaminoacid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson’s disease. Hum Gene Ther, 2000, 11(11):1509~1519
[12] Azzouz M, MartinRendon E, Barber R D, et al. Multicistronic lentiviral vectormediated striatal gene transfer of aromatic Lamino acid decarboxylase,tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression,dopamine production, and functional improvement in a rat model of Parkinson’s disease.J Neurosci, 2002, 22(23): 10302~10312
[13] Mandel R J, Rendahl K G, Spratt S K, et al. Characterization of intrastriatal recombinant adenoassociated virusmediated gene transfer of human tyrosine hydroxylase and human GTPcyclohydrolase I in a rat model of parkinson’s disease. J Neurosci,1998,18(11): 4271~4284
[14] Li N, Yang H, Lu L L, et al. Spontaneous expression of neural phenotype and NGF, TrkA, TrkB genes in marrow stromal cells. Biochem and Biophys Res Commun,2007,356 (3): 561~568
[15] Kim S, Honmou O, Kato K, et al. Neural differentiation potential of peripheral blood and bonemarrowderived precursor cells. Brain Res , 2006, 1123(1):27~33
[16] 鲁玲玲,刘玉军,孙晓红等,骨髓间充质干细胞在大鼠体内的迁移研究。中国生物工程杂志, 2005,25(4):22~28
Lu L L, Liu Y J, Sun X H,et al.China Biotechnology,2005, 25(4): 22~28 |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|