空间组学技术发展趋势的专利分析<sup>*</sup>

doi:10.13523/j.cb.2304056

中国生物工程杂志

2023, Vol. 43

Issue (8): 111-117 DOI: 10.13523/j.cb.2304056

专利

空间组学技术发展趋势的专利分析^*

马莉¹,崔海星¹,李金泽^2,^**(

)

1 国家知识产权局专利局专利审查协作江苏中心苏州 215163
2 中国科学院苏州生物医学工程技术研究所苏州 215163

Analysis of Patent Trends for the Spatial Omics Technology

MA Li¹,CUI Hai-xing¹,LI Jin-ze^2,^**(

)

1 Patent Examination Cooperation (Jiangsu) Center of the Patent Office, CNIPA, Suzhou 215163, China
2 Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China

全文: PDF(1415 KB) HTML

摘要：

空间组学以分子的视角揭示细胞间的微环境互作及空间异质性,在神经科学、癌症研究和发育生物学等领域发挥重要作用。该技术的学术热度较高,却一直处于“垄断式”发展。从空间组学技术在全球和中国专利申请的整体情况入手,分析了该领域全球和中国相关专利申请的变化趋势、技术主题、申请来源、主要申请人等,梳理了该领域关键技术的发展状况。同时,基于上述分析,对我国在空间组学领域的技术突破点和发展模式提出了建议。

关键词： 空间组学; 空间转录组; 原位杂交; 原位测序; 激光捕获显微切割

Abstract:

Spatial omics reveals micro-environment interactions and spatial heterogeneity between cells from a molecular perspective, which plays an important role in neuroscience, cancer research and developmental biology. The spatial omics technology has received a lot of academic attention, but it has been developing in a monopolistically competitive environment. Based on the overall situation of the global and Chinese patent applications of the spacial omics technology, this paper analyzes the trends, technical themes, application sources and main applicants of the global and Chinese patent technologies in this field, and summarizes the development status of the key technologies. At the same time, based on the above analysis, some suggestions are put forward on the technical breakthrough and development mode in the field of spatial omics.

Key words: Spatial omics Spatial transcriptome In situ hybridization In situ sequencing Laser capture microdissection

收稿日期: 2023-04-28 出版日期: 2023-09-05

ZTFLH:

Q819

基金资助: 国家重点研发计划(2022YFC2409300)

通讯作者: **电子信箱:lijz@sibet.ac.cn

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引用本文:

马莉, 崔海星, 李金泽. 空间组学技术发展趋势的专利分析^*[J]. 中国生物工程杂志, 2023, 43(8): 111-117.

MA Li, CUI Hai-xing, LI Jin-ze. Analysis of Patent Trends for the Spatial Omics Technology. China Biotechnology, 2023, 43(8): 111-117.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2304056 或 https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I8/111

图1 全球及在华专利申请量变化趋势

图2 空间组学技术的分类占比图

图3 原位空间组学技术的发展历程

图4 取样空间组学技术的发展历程

图5 编码空间组学技术的发展历程

图6 申请人的申请量排名

图7 在华专利申请来源国分布

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