肺类器官模型在感染性肺系病研究中的应用及展望<sup>*</sup>

doi:10.13523/j.cb.2304026

中国生物工程杂志

2023, Vol. 43

Issue (8): 30-37 DOI: 10.13523/j.cb.2304026

类器官构建与应用专题

肺类器官模型在感染性肺系病研究中的应用及展望^*

石瑾¹,刘柯²,丁军颖^2,^**(

)

1 首都医科大学附属北京中医医院北京 100010
2 首都医科大学附属北京中医医院北京市中医药研究所中医感染性疾病基础研究北京市重点实验室北京 100010

Application and Prospects of Lung Organoid Models in the Study of Infectious Lung Diseases

SHI Jin¹,LIU Ke²,DING Jun-ying^2,^**(

)

1 Department of Clinical Laboratory, Beijing Hospital of Traditional Chinese Medicine (TCM), Capital Medical University, Beijing 100010, China
2 Beijing Key Laboratory of Basic Research with TCM on Infectious Diseases, Beijing Institute of Chinese Medicine, Beijing Hospital of TCM, Capital Medical University, Beijing 100010, China

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摘要：

肺是病毒、细菌等病原体感染和损伤的重要靶器官。近年新冠疫情让我们认识到,感染性肺系病严重威胁人类健康,甚至生命。基于肺系病发病机制及防治机制研究的迫切性,肺类器官以其精准模拟、高适用性和无伦理困扰等特点,日益成为该领域研究的得力工具。在追溯其研发轨迹的基础上,综述其构建及在不同感染肺系病中的应用,并预期其未来发展前景。

关键词： 多能干细胞; 肺类器官; 感染性肺系病; 病原体

Abstract:

Lung is an important target organ for infection and injury by viruses, bacteria and other pathogens. In recent years, the novel coronavirus epidemic has made us realize that infectious pulmonary diseases pose a serious threat to human health, even life. Due to the urgency of the research on the pathogenesis and prevention mechanism of pulmonary diseases, lung organoids are increasingly becoming effective tools for research in this field due to their characteristics such as accurate simulation, high applicability and no ethical concerns. On the basis of tracing its development, this paper reviews the construction and application of lung organoid models in different infectious pulmonary diseases, and anticipates the future development prospects of the models.

Key words: Pluripotent stem cells Lung organoids Infectious pulmonary disease Pathogen

收稿日期: 2023-04-13 出版日期: 2023-09-05

ZTFLH:

R-33

基金资助: 北京市高层次公共卫生技术人才建设(2022-3-009)

通讯作者: **电子信箱:dingjunying@bjzhongyi.com

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引用本文:

石瑾, 刘柯, 丁军颖. 肺类器官模型在感染性肺系病研究中的应用及展望^*[J]. 中国生物工程杂志, 2023, 43(8): 30-37.

SHI Jin, LIU Ke, DING Jun-ying. Application and Prospects of Lung Organoid Models in the Study of Infectious Lung Diseases. China Biotechnology, 2023, 43(8): 30-37.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2304026 或 https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I8/30

图1 肺类器官的来源及构建

图2 肺类器官模型在感染性肺系病中的应用

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