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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2023, Vol. 43 Issue (8): 1-10    DOI: 10.13523/j.cb.2302013
类器官构建与应用专题     
类器官领域发展现状及展望*
王玥,施慧琳,靳晨琦,徐萍**()
中国科学院上海营养与健康研究所 中国科学院上海生命科学信息中心 上海 200031
Development Status and Prospects of Organoids
WANG Yue,SHI Hui-lin,JIN Chen-qi,XU Ping**()
Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China
 全文: PDF(793 KB)   HTML
摘要：

类器官技术的出现与快速发展极大的提升了人造组织器官的制造水平,拓展了其应用范围,同时也为生物医药行业的发展带来全新机遇。对类器官相关技术、应用和产业发展现状进行分析,显示目前类器官技术正处于爆发期,组织器官结构和功能的模拟水平不断提高,在血管化等核心瓶颈问题的攻关方面也不断取得突破,而其与器官芯片融合产生的类器官芯片技术更是极大地提升了该技术的应用能力。目前,类器官作为一种生物模型,在生物医学科研、临床治疗及药物研发中均已展现出可观的应用前景,尤其是在药物研发领域,相关产业体系正在逐渐成型,发展进程快速推进。未来随着相关技术瓶颈的攻克以及商业资本进一步涌入,类器官领域必将孕育更广阔的发展空间,进而助力生物医药行业的创新发展。
关键词： 类器官;  再生医学;  生物模型;  药物研发    
Abstract:

The emergence and rapid development of the organoid technology has greatly improved the manufacturing ability of artificial tissues and organs, expanded the application scope of regenerative medicine, and also brought new opportunities for the development of the biomedicine industry. The analysis of the development status of the organoid technology, its application direction and industry development shows that this field is in a period of rapid growth. First, the organoid technology is in a period of explosive growth at present, the simulation level of structure and function of tissues and organs is constantly improved, and breakthroughs have been made in solving core “bottleneck” problems such as vascularization. Second, the organoids-on-a-chip technology produced by the fusion of the organoid technology and organ-on-a-chip has greatly improved the application ability of organoids. Finally, as a biological model, organoids have shown considerable application prospects in biomedical research, clinical treatment and drug research and development. Especially in drug research and development, the relevant industrial system is gradually taking shape, and the development process is advancing rapidly. In the future, with breakthoughs made in overcoming relevant technical bottlenecks and the further influx of commercial capital, the field of organoids will certainly have a broader development space, which will help the innovation and development of the biomedicine industry.
Key words: Organoid    Regenerative    medicine    Biological    model    Medicine    development
收稿日期: 2023-02-09 出版日期: 2023-09-05
ZTFLH:  Q819  
基金资助: 中国科学院重点部署项目(KJZD-SW-L09)
通讯作者: **电子信箱:xuping@sinh.ac.cn   
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引用本文:

王玥, 施慧琳, 靳晨琦, 徐萍. 类器官领域发展现状及展望*[J]. 中国生物工程杂志, 2023, 43(8): 1-10.

WANG Yue, SHI Hui-lin, JIN Chen-qi, XU Ping. Development Status and Prospects of Organoids. China Biotechnology, 2023, 43(8): 1-10.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2302013    或    https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I8/1

图1  全球类器官领域论文数量年度分布
图2  类器官的主要应用场景
药物企业 类器官企业 合作事项 时间
阿斯利康 Emulate 类器官芯片技术嵌入到阿斯利康的IMED药物安全实验室中 2018年
辉瑞 Hubrecht Organoid Technology 合作开发人类肠道类器官平台,用于克罗恩病、溃疡性结肠炎的
药物靶标识别和药物筛选		 2018年
辉瑞 System1 Biosciences 辉瑞领投,开发大脑类器官 2018年
赛诺菲 Hesperos NCT04658472临床前研究 2021年
Crown Bioscience Crown Bioscience 利用类器官平台对细胞药物进行筛选和表征 2022年
百时美施贵宝 Prellis 基于其人体淋巴结类器官,开发针对人类蛋白质的高亲和力人类抗体 2022年
赛诺菲 Prellis 利用其淋巴结类器官,在体外重建免疫反应,以助力抗体药物的开发 2022年
表1  药物研发企业与类器官企业合作案例
公司名称 融资情况 融资时间 研发方向
丹望医疗 1.2亿元A轮融资 2021年 专注类器官疾病模型的平台型公司
创芯国际 1亿元 pre-B轮融资 2022年 提供科研与临床精准治疗的肿瘤类器官药物敏感性检测平台、新药研发服务
大橡科技 近亿元pre-B轮融资 2022年 类器官芯片在新药研发、疾病建模和个体化精准医疗等领域的广泛应用
科途医学 数千万A轮融资 2022年 专注于肿瘤类器官功能性检测技术的研发和成果转化
艾玮得生物 近亿元pre-A轮融资 2022年 重点从事人体器官芯片及配套装备的研发和应用
伯桢生物 亿元A轮融资 2023年 类器官自动化设备、多组织全流程试剂盒、类器官培养和样本库构建技术
方案、类器官药物研发和精准医疗子系统等
表2  我国部分类器官研发公司的融资情况
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