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脑血管内皮细胞Prmt5基因敲除导致小胶质细胞激活并影响血脑屏障完整性* |
韩钰莹1,2,宁慧敏1,2,张一哲2,宋晓朋2,许成芳2,蔡云婷2,杨晓1,2,**(),王俊2,**() |
1 青岛大学基础医学院 青岛 266071 2 军事科学院军事医学研究院生命组学研究所 蛋白质组学国家重点实验室 北京 102206 |
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Mice Lacking Prmt5 in Cerebral Vascular Endothelial Cells Showing Microglial Activation and Protecting Blood-brain Barrier Integrity |
HAN Yu-ying1,2,NING Hui-min1,2,ZHANG Yi-zhe2,SONG Xiao-peng2,XU Cheng-fang2,CAI Yun-ting2,YANG Xiao1,2,**(),WANG Jun2,**() |
1 School of Basic Medicine, Qingdao University, Qingdao 266071, China 2 State Key Laboratory of Proteomics, Beijing National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China |
引用本文:
韩钰莹, 宁慧敏, 张一哲, 宋晓朋, 许成芳, 蔡云婷, 杨晓, 王俊. 脑血管内皮细胞Prmt5基因敲除导致小胶质细胞激活并影响血脑屏障完整性*[J]. 中国生物工程杂志, 2023, 43(5): 1-10.
HAN Yu-ying, NING Hui-min, ZHANG Yi-zhe, SONG Xiao-peng, XU Cheng-fang, CAI Yun-ting, YANG Xiao, WANG Jun. Mice Lacking Prmt5 in Cerebral Vascular Endothelial Cells Showing Microglial Activation and Protecting Blood-brain Barrier Integrity. China Biotechnology, 2023, 43(5): 1-10.
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https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2212013
或
https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I5/1
|
[1] |
Zhao Z, Nelson A R, Betsholtz C, et al. Establishment and dysfunction of the blood-brain barrier. Cell, 2015, 163(5): 1064-1078.
doi: S0092-8674(15)01423-3
pmid: 26590417
|
[2] |
Sweeney M D, Zhao Z, Montagne A, et al. Blood-brain barrier: from physiology to disease and back. Physiological Reviews, 2019, 99(1): 21-78.
doi: 10.1152/physrev.00050.2017
pmid: 30280653
|
[3] |
Winkler E A, Bell R D, Zlokovic B V. Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Molecular Neurodegeneration, 2010, 5: 32.
doi: 10.1186/1750-1326-5-32
pmid: 20738866
|
[4] |
Willis C L, Nolan C C, Reith S N, et al. Focal astrocyte loss is followed by microvascular damage, with subsequent repair of the blood-brain barrier in the apparent absence of direct astrocytic contact. Glia, 2004, 45(4): 325-337.
pmid: 14966864
|
[5] |
Liebner S, Dijkhuizen R M, Reiss Y, et al. Functional morphology of the blood-brain barrier in health and disease. Acta Neuropathologica, 2018, 135(3): 311-336.
doi: 10.1007/s00401-018-1815-1
pmid: 29411111
|
[6] |
Walsh J, Tozer D J, Sari H S, et al. Microglial activation and blood-brain barrier permeability in cerebral small vessel disease. Brain: a Journal of Neurology, 2021, 144(5): 1361-1371.
doi: 10.1093/brain/awab003
|
[7] |
Ueno M, Fujita Y, Tanaka T, et al. Layer V cortical neurons require microglial support for survival during postnatal development. Nature Neuroscience, 2013, 16(5): 543-551.
doi: 10.1038/nn.3358
pmid: 23525041
|
[8] |
Fu R Y, Shen Q Y, Xu P F, et al. Phagocytosis of microglia in the central nervous system diseases. Molecular Neurobiology, 2014, 49(3): 1422-1434.
doi: 10.1007/s12035-013-8620-6
pmid: 24395130
|
[9] |
Paolicelli R C, Bolasco G, Pagani F, et al. Synaptic pruning by microglia is necessary for normal brain development. Science, 2011, 333(6048): 1456-1458.
doi: 10.1126/science.1202529
pmid: 21778362
|
[10] |
Girard S, Brough D, Lopez-Castejon G, et al. Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices. Glia, 2013, 61(5): 813-824.
doi: 10.1002/glia.22478
pmid: 23404620
|
[11] |
Hu X M, Leak R K, Shi Y J, et al. Microglial and macrophage polarization:new prospects for brain repair. Nature Reviews Neurology, 2015, 11(1): 56-64.
doi: 10.1038/nrneurol.2014.207
|
[12] |
Ma Y Y, Wang J X, Wang Y T, et al. The biphasic function of microglia in ischemic stroke. Progress in Neurobiology, 2017, 157: 247-272.
doi: S0301-0082(15)30070-8
pmid: 26851161
|
[13] |
Haruwaka K, Ikegami A, Tachibana Y, et al. Dual microglia effects on blood brain barrier permeability induced by systemic inflammation. Nature Communications, 2019, 10(1): 1-17.
doi: 10.1038/s41467-018-07882-8
|
[14] |
Blanc R S, Richard S. Arginine methylation: the coming of age. Molecular Cell, 2017, 65(1): 8-24.
doi: S1097-2765(16)30711-0
pmid: 28061334
|
[15] |
Wu Q, Schapira M, Arrowsmith C H, et al. Protein arginine methylation: from enigmatic functions to therapeutic targeting. Nature Reviews Drug Discovery, 2021, 20(7): 509-530.
doi: 10.1038/s41573-021-00159-8
pmid: 33742187
|
[16] |
Quillien A, Gilbert G, Boulet M, et al. Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity. PLoS Genetics, 2021, 17(6): e1009641.
doi: 10.1371/journal.pgen.1009641
|
[17] |
宁慧敏, 张一哲, 韩钰莹, 等. 脑血管内皮细胞敲除Prmt5导致脑血管损伤及星形胶质细胞活化. 中国生物工程杂志, 2022, 42(4): 1-8.
|
|
Ning H M, Zhang Y Z, Han Y Y, et al. Deletion of Prmt 5 in cerebral endothelial cells leads to cerebrovascular disease and astrocyte activation. China Biotechnology, 2022, 42(4): 1-8.
|
[18] |
Li F F, Lan Y, Wang Y L, et al. Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Developmental Cell, 2011, 20(3): 291-302.
doi: 10.1016/j.devcel.2011.01.011
pmid: 21397841
|
[19] |
Li Z, Lan Y, He W Y, et al. Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell, 2012, 11(5): 663-675.
doi: 10.1016/j.stem.2012.07.004
pmid: 23122290
|
[20] |
Bassett B, Subramaniyam S, Fan Y, et al. Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis. Brain, Behavior, and Immunity, 2021, 91: 519-530.
doi: 10.1016/j.bbi.2020.11.009
pmid: 33176182
|
[21] |
Lan X, Han X N, Li Q, et al. Modulators of microglial activation and polarization after intracerebral haemorrhage. Nature Reviews Neurology, 2017, 13(7): 420-433.
doi: 10.1038/nrneurol.2017.69
pmid: 28524175
|
[22] |
Chiu I, Morimoto E A, Goodarzi H, et al. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Reports, 2013, 4(2): 385-401.
doi: 10.1016/j.celrep.2013.06.018
pmid: 23850290
|
[23] |
Morganti J M, Riparip L K, Rosi S. Call off the dog(ma): M1/M2 polarization is concurrent following traumatic brain injury. PLoS One, 2016, 11(1): e0148001.
doi: 10.1371/journal.pone.0148001
|
[24] |
Waisman A, Ginhoux F, Greter M, et al. Homeostasis of microglia in the adult brain: review of novel microglia depletion systems. Trends in Immunology, 2015, 36(10): 625-636.
doi: S1471-4906(15)00197-0
pmid: 26431940
|
[25] |
Elmore M P, Najafi A, Koike M, et al. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron, 2014, 82(2): 380-397.
doi: 10.1016/j.neuron.2014.02.040
pmid: 24742461
|
[26] |
Rice R A, Pham J, Lee R J, et al. Microglial repopulation resolves inflammation and promotes brain recovery after injury. Glia, 2017, 65(6): 931-944.
doi: 10.1002/glia.23135
pmid: 28251674
|
[27] |
Chen A Q, Fang Z, Chen X L, et al. Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke. Cell Death & Disease, 2019, 10(7): 1-18.
|
[28] |
Parkhurst C, Yang G, Ninan I, et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell, 2013, 155(7): 1596-1609.
doi: 10.1016/j.cell.2013.11.030
pmid: 24360280
|
[29] |
Li Y F, Ren X, Zhang L, et al. Microglial polarization in TBI: Signaling pathways and influencing pharmaceuticals. Frontiers in Aging Neuroscience, 2022, 14: 901117.
doi: 10.3389/fnagi.2022.901117
|
[30] |
Hu X M, Li P Y, Guo Y L, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke, 2012, 43(11): 3063-3070.
doi: 10.1161/STROKEAHA.112.659656
pmid: 22933588
|
[31] |
Yousef H, Czupalla C J, Lee D, et al. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nature Medicine, 2019, 25(6): 988-1000.
doi: 10.1038/s41591-019-0440-4
pmid: 31086348
|
[32] |
Li Z L, Korhonen E A, Merlini A, et al. Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS. The Journal of Clinical Investigation, 2020, 130(4): 1977-1990.
doi: 10.1172/JCI130308
|
[33] |
Jiang X Y, Andjelkovic A V, Zhu L, et al. Blood-brain barrier dysfunction and recovery after ischemic stroke. Progress in Neurobiology, 2018, 163-164: 144-171.
doi: S0301-0082(16)30173-3
pmid: 28987927
|
[34] |
Sweeney M D, Sagare A P, Zlokovic B V. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nature Reviews Neurology, 2018, 14(3): 133-150.
doi: 10.1038/nrneurol.2017.188
pmid: 29377008
|
[35] |
Niu J Q, Tsai H H, Hoi K K, et al. Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Nature Neuroscience, 2019, 22(5): 709-718.
doi: 10.1038/s41593-019-0369-4
pmid: 30988524
|
[36] |
Rüber T, David B, Lüchters G, et al. Evidence for peri-ictal blood-brain barrier dysfunction in patients with epilepsy. Brain, 2018, 141(10): 2952-2965.
doi: 10.1093/brain/awy242
pmid: 30239618
|
[37] |
Gasche Y, Fujimura M, Morita-Fujimura Y, et al. Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood-brain barrier dysfunction. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 1999, 19(9): 1020-1028.
doi: 10.1097/00004647-199909000-00010
|
[38] |
Lucivero V, Prontera M, Mezzapesa D M, et al. Different roles of matrix metalloproteinases-2 and-9 after human ischaemic stroke. Neurological Sciences, 2007, 28(4): 165-170.
pmid: 17690845
|
[39] |
Rosell A, Cuadrado E, Ortega-Aznar A, et al. MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke, 2008, 39(4): 1121-1126.
doi: 10.1161/STROKEAHA.107.500868
pmid: 18323498
|
[40] |
Mehrabadi A R, Korolainen M A, Odero G, et al. Poly(ADP-ribose) polymerase-1 regulates microglia mediated decrease of endothelial tight junction integrity. Neurochemistry International, 2017, 108: 266-271.
doi: S0197-0186(17)30192-4
pmid: 28461173
|
[41] |
Daniel Lee C Y, Daggett A, Gu X F, et al. Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer’s disease models. Neuron, 2018, 97(5): 1032-1048.e5.
doi: S0896-6273(18)30101-6
pmid: 29518357
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