PLGA作为抗原递送系统的研究进展<sup>*</sup>

doi:10.13523/j.cb.2211040

中国生物工程杂志

2023, Vol. 43

Issue (5): 69-75 DOI: 10.13523/j.cb.2211040

综述

PLGA作为抗原递送系统的研究进展^*

郑蕊^1,²,屠叶清²,王慧²,罗德炎^2,^**(

)

1 安徽医科大学基础医学院合肥 230032
2 军事科学院军事医学研究院微生物流行病研究所病原微生物生物安全国家重点实验室北京 100071

Research Progress of PLGA as Antigen Delivery System

ZHENG Rui^1,²,TU Ye-qing²,WANG Hui²,LUO De-yan^2,^**(

)

1 School of Basic Medical Science, Anhui Medical University, Hefei 230032, China
2 State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medicine, Academy of Military Science, Beijing 100071, China

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摘要：

近年来新冠病毒肆虐,单针剂的疫苗研制备受关注。传统疫苗制剂需要在一段时间内多次反复接种才能产生足够的中和抗体。为了降低疫苗接种次数、提高人们的疫苗接种依从性,高分子聚合物材料逐渐走进人们视野,其中聚乳酸-羟基乙酸共聚物(poly lactic-co-glycolic acid, PLGA)是当前研究最多、应用最广泛的高分子聚合物材料。PLGA作为一种人工合成的高分子聚合物材料,易于制备、价格相对较低,且具有良好的缓释特性,以及生物安全性和组织相容性,已经被FDA批准应用于药物递送系统,但在疫苗研发上方兴未艾。总结了PLGA佐剂的基本信息,根据当前疫苗研究趋势分析整理了影响其缓释效果和免疫调节作用的相关因素,以及当前的不足和限制,为后续疫苗制备和研究提供一些思路。

关键词： PLGA; 缓释; 免疫调节; 表面性质

Abstract:

In recent years, due to the ravages of the COVID-19, the development of single-injection vaccine has attracted much attention. Traditional vaccine preparations need to be inoculated repeatedly for a period of time to produce enough neutralizing antibodies. In order to reduce the number of vaccination shots and improve people’s vaccination compliance, polymer materials have gradually entered people’s field of vision. Among them, Poly lactic-co-glycolic acid (PLGA) is one of the most studied and widely used polymer materials. As a synthetic polymer material, PLGA is easy to prepare and relatively low in price, and it has favorable sustained release characteristics and has good biosafety and histocompatibility. It has been approved by the U.S. Food and Drug Administration (FDA) as a drug delivery system, but it is in the ascendant in vaccine research and development. Based on the current research progress, this article summarizes the basic information of PLGA adjuvants and the related factors affecting their sustained release effect and immunomodulatory effects, so as to provide some ideas for subsequent vaccine preparation and research.

Key words: PLGA Sustained release Immunoregulation Surface property

收稿日期: 2022-11-20 出版日期: 2023-06-01

ZTFLH:

Q819

基金资助: ^*国家自然科学基金(31870156)

通讯作者: **电子信箱: ldy612@126.com

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引用本文:

郑蕊, 屠叶清, 王慧, 罗德炎. PLGA作为抗原递送系统的研究进展^*[J]. 中国生物工程杂志, 2023, 43(5): 69-75.

ZHENG Rui, TU Ye-qing, WANG Hui, LUO De-yan. Research Progress of PLGA as Antigen Delivery System. China Biotechnology, 2023, 43(5): 69-75.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2211040 或 https://manu60.magtech.com.cn/biotech/CN/Y2023/V43/I5/69

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