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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2022, Vol. 42 Issue (4): 68-77    DOI: 10.13523/j.cb.2110002
综述     
miR-138生物学功能研究进展*
冉宏标,王会**(),钟金城**()
西南民族大学青藏高原动物遗传资源保护与利用四川省/教育部重点实验室 成都 610041
Research Progress on Biological Functions of miR-138
RAN Hong-biao,WANG Hui**(),ZHONG Jin-cheng**()
Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu 610041, China
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摘要：

microRNAs(miRNAs)是真核生物体内高度保守的非编码小分子RNA,具有多种生物学功能,参与疾病发生和发展、细胞增殖和分化等多种病理及生理过程的调控。miR-138作为一种肿瘤抑制因子已在肿瘤发生与治疗中被广泛研究和应用,同时在心血管及神经系统疾病、成骨分化、脂肪生成及卵巢功能维持等生命过程中具有调控作用。在总结分析miR-138相关功能最新研究进展的基础上,对miR-138的潜在研究方向进行了分析、讨论和展望,旨在为进一步深入探明miR-138的生物学功能提供参考和理论依据。
关键词： miR-138;  疾病;  成骨分化;  脂肪;  卵巢    
Abstract:

microRNAs(miRNAs)are highly conserved non-coding small RNA in eukaryotes. They have many biological functions and can participate in the regulation of disease, cell proliferation and differentiation and other biological process. miR-138 as a tumor suppressor has been widely studied in tumorigenesis and therapy and also plays a regulatory role in cardiovascular and neurological disorder processes, osteogenic differentiation, adipogenesis and ovarian function maintenance. In this paper, prospects for future research direction of miR-138 are analyzed and discussed on the basis of summarizing and analyzing the latest research progress of miR-138 related functions, aiming to provide reference and theoretical basis for exploring miR-138 biological functions in the future.
Key words: miR-138    Disease    Osteogenic differentiation    Lipid    Ovarian
收稿日期: 2021-10-05 出版日期: 2022-05-05
ZTFLH:  Q52  
基金资助: * 四川省科技计划(2019YJ0257);财政部和农业农村部国家现代农业产业技术体系(CARS-37)
通讯作者: 王会,钟金城     E-mail: wanghui892321@sina.cn;zhongjincheng518@126.com
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引用本文:

冉宏标,王会,钟金城. miR-138生物学功能研究进展*[J]. 中国生物工程杂志, 2022, 42(4): 68-77.

RAN Hong-biao,WANG Hui,ZHONG Jin-cheng. Research Progress on Biological Functions of miR-138. China Biotechnology, 2022, 42(4): 68-77.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2110002    或    https://manu60.magtech.com.cn/biotech/CN/Y2022/V42/I4/68

图1  miR-138前体同源性比对
肿瘤 靶标基因 功能 参考文献
肺癌 SOX4/PD-L1 抑制细胞增殖、聚集和迁移,诱导细胞凋亡/抑制肿瘤生长,激活免疫系统 [9-10]
胃癌 DEK/E2F2 抑制细胞增殖、迁移,阻碍细胞生长并促进凋亡 [11-12]
肝癌 FOXC1/EZH2 抑制肝癌细胞的转移和生长能力/增强预后敏感性 [13-14]
宫颈癌 H2AX/PLXNB2 抑制癌细胞增殖、侵袭,增加凋亡和增强化疗敏感性/抑制细胞活性与侵袭能力 [15-16]
乳腺癌 HIF-1a 减弱细胞增殖及活性,增强细胞凋亡及药物敏感性 [17]
膀胱癌 survivin/SIRT1 抑制细胞增殖和侵袭/促进细胞凋亡,抑制恶性增殖 [18-19]
卵巢癌 EZH2/SIRT1/Bcl-2 抑制细胞增殖和促进凋亡、增强癌细胞药物敏感性 [20]
胶质母细胞瘤 CD44/CREB1 抑制细胞增殖和迁移,增强细胞凋亡/抑制肿瘤细胞增殖、侵袭,促进细胞凋亡 [2,21]
神经胶质瘤 IGF2BP2 抑制体外肿瘤细胞增殖、迁移,通过抑制上皮细胞向间充质细胞转移减缓肿瘤侵袭能力 [22]
神经母细胞瘤 DEK/CCND3 抑制细胞增殖生长,促进细胞凋亡敏感性/抑制肿瘤细胞聚集、侵袭和活性 [23-24]
黑色素瘤 CD105/TCF4 抑制肿瘤细胞侵袭能力/抑制细胞增殖、侵袭及转化 [25-26]
胆管癌 SOX4 降低肿瘤细胞存活率,与不良预后存在相关性 [27]
前列腺癌 FOXC1 抑制肿瘤恶性增殖,与淋巴结转移与预后效果存在关联 [28]
结直肠癌 PDK1/NFIB/4EBP1/CCND1 降低耐药性,促进癌细胞凋亡/抑制细胞迁移及耐药能力 [29-30]
[31-32]
骨肉瘤 ROCK1 降低细胞存活率,与预后效果不佳有关 [33]
表1  miR-138影响肿瘤生长及药物敏感性
图2  miR-138调控网络
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