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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2022, Vol. 42 Issue (1/2): 139-145    DOI: 10.13523/j.cb.2107055
综述     
噬菌体温度适应性的研究进展*
李金花,白雨凡,马春兰,季秀玲,魏云林()
昆明理工大学生命科学与技术学院 昆明 650500
Research Progress on Temperature Adaptation of Bacteriophage
LI Jin-hua,BAI Yu-fan,MA Chun-lan,JI Xiu-ling,WEI Yun-lin()
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
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摘要：

噬菌体在自然界中分布广泛,是一类感染细菌的病毒总称。同时噬菌体繁殖迅速,对宿主的选择具有非常高的特异性,当其作为细菌感染的抗生素替代疗法时不易让宿主菌形成耐药性。因其严格寄生,其增殖过程除受环境因素(pH、离子强度、温度)影响外,往往还受宿主代谢水平的影响。在外部环境因素中,温度对噬菌体的影响尤为突出,其对噬菌体的活性、稳定性、保藏和进化等都有重要影响。对噬菌体在温度适应性机制研究方面的研究进展进行了总结,重点对噬菌体在温度胁迫下的适应性进化研究进行了整理和归纳,以期为进一步开展噬菌体研究提供帮助。
关键词： 噬菌体;  细菌;  温度;  适应性;  进化    
Abstract:

Bacteriophages are widely distributed in nature. They are a kind of viruses that infect only bacteria. Phages multiply rapidly and have very high specificity for host selection, and are less likely to cause host bacteria to develop resistance when they are used as an antibiotic replacement therapy for bacterial infections. Because it is strictly selected by parasitism, its proliferation process is affected not only by environmental factors (pH, ionic strength, temperature), but also by the host metabolic level. Among the external environmental factors, temperature has an important influence on phage activity, stability, preservation and evolution. In this paper, the research progress of phage in temperature adaptation mechanism was summarized. In addition, the research on phage adaptation evolution under temperatures stress was classified further, and thus will provide help for research in this field.
Key words: Bacteriophage    Bacterial    Temperature    Adaptation    Evolution
收稿日期: 2021-07-25 出版日期: 2022-03-03
ZTFLH:  Q819  
基金资助: * 国家自然科学基金(31960232)
通讯作者: 魏云林     E-mail: homework18@126.com
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引用本文:

李金花,白雨凡,马春兰,季秀玲,魏云林. 噬菌体温度适应性的研究进展*[J]. 中国生物工程杂志, 2022, 42(1/2): 139-145.

LI Jin-hua,BAI Yu-fan,MA Chun-lan,JI Xiu-ling,WEI Yun-lin. Research Progress on Temperature Adaptation of Bacteriophage. China Biotechnology, 2022, 42(1/2): 139-145.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2107055    或    https://manu60.magtech.com.cn/biotech/CN/Y2022/V42/I1/2/139

温度 /℃ 噬菌体(宿主) 科 衣壳形态 其他特点 基因组类型 参考文献
55~95 AP45(气生芽孢杆菌CEMTC656) 长尾噬菌体科 二十面体(60 nm) 长的尾巴(160 nm) dsDNA [12]
80 ID8(大肠杆菌C) 微小噬菌体科 二十面体 有包膜和衣壳结构 ssDNA [13]
60~70 Wc4(胡萝卜软腐果胶杆菌亚种KPM17) 肌尾噬菌体科 二十面体[(57.5±5.0)nm] 长不可收缩尾 [(97.3±3.6)nm] dsDNA [14]
CX5(阿托品杆菌WHG10001) 短尾噬菌体科 二十面体[(55.6±3.0)nm] 短不可收缩尾[(18.0±2)nm]
P-PSG-11(青枯雷尔氏菌) 短尾噬菌体科 二十面体[(42.7±2.6)nm] 短不可收缩尾[(12.0±2.3)nm]
40~60 PSM6(肠炎沙门氏菌) 肌尾噬菌体科 二十面体(72 nm) 短末端纤维细长的尾(122.0 nm) dsDNA [15]
40~50 vB_EcoM_F2(大肠杆菌) 肌尾噬菌体科 二十面体(60 nm) 可收缩尾(150.0 nm) dsDNA [16]
25~45 vB_SauS_SAP3(金黄色葡萄球菌D085)
vB_SauS_SH-St 15644(耐甲氧西林金黄色葡萄球菌)		 长尾噬菌体科 二十面体[(60nm±5)nm]
二十面体(长:75.0 nm; 宽:40.0 nm)		 长而灵活的尾[(170±5)nm]
长非收缩性尾(长:250 nm;宽:20 nm)		 dsDNA [17-18]
20~50 vB-SdyS-ISF003(痢疾链球菌PTCC 1188) 长尾噬菌体科 二十面体[长:(70±3.0)nm;宽:(55±3.0)nm] 无收缩尾[(160±5.0)nm] dsDNA [19]
PH1(交替假单胞菌BH1) 短尾噬菌体科 二十面体(60.0 nm) 短尾 (26.0 nm) dsDNA [20]
25和37 øBp-AMP1(类鼻疽伯克氏菌K96243) 短尾噬菌体科 二十面体 不可收缩尾 dsDNA [21]
4~32 vB_PagS_AAS21(成团泛菌) 长尾噬菌体科 二十面体[(84.75±3.20)nm] 不可收缩,灵活的长尾[长:(173.59 ± 11.52)nm;宽:(10.27 ± 0.87) nm] dsDNA [22]
4~37 VMY22(蜡样芽孢杆菌) 短尾噬菌体科 二十面体(长:59.2 nm;宽:31.9 nm) 短尾(43.2 nm) dsDNA [4]
4~28 VSW-3(荧光假单胞菌) 短尾噬菌体科 二十面体(56 nm) 短尾(20 nm×12 nm) dsDNA [6]
4~25 VW-6和VW-6B(荧光假单胞菌) 长尾噬菌体科 二十面体(66.7 nm;61.1 nm) 长尾(长:233.3 nm;宽:8.3 nm。长:166.7 nm;宽:11.1 nm) dsDNA [7]
4~20 MYSP06(紫色杆菌MYB06) 长尾噬菌体科 二十面体(74 nm) 长尾(长:210 nm;宽:10 nm) dsDNA [5]
-20~4 PH1(交替假单胞菌BH1) 短尾噬菌体科 二十面体(60.0 nm) 短尾(26.0 nm) dsDNA [20]
vB-SdyS-ISF003(痢疾链球菌PTCC 1188) 长尾噬菌体科 二十面体[长:(70±3.0)nm;宽:(55±3.0)nm] 无收缩尾[(160±5.0)nm] dsDNA [19]
-12和8 9A(冷红科韦尔氏菌34H) 长尾噬菌体科 二十面体 长而灵活的尾 dsDNA [23]
表1  不同温度下噬菌体的分布及主要特征
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