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RS4651通过上调SMAD7抑制小鼠肝细胞AML12的EMT作用 |
李世荣1,陈阳琴1,张春盼1,2,齐文杰1,*() |
1 首都医科大学附属北京友谊医院 北京 100050 2 国家消化系统疾病临床医学研究中心 北京 100050 |
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RS4651 Inhibits the EMT of Mouse Hepatocyte AML12 via Upregulating SMAD7 |
LI Shi-rong1,CHEN Yang-qin1,ZHANG Chun-pan1,2,QI Wen-jie1,*() |
1 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China 2 National Clinical Research Center for Digestive Disease, Beijing 100050, China |
引用本文:
李世荣,陈阳琴,张春盼,齐文杰. RS4651通过上调SMAD7抑制小鼠肝细胞AML12的EMT作用[J]. 中国生物工程杂志, 2021, 41(7): 1-9.
LI Shi-rong,CHEN Yang-qin,ZHANG Chun-pan,QI Wen-jie. RS4651 Inhibits the EMT of Mouse Hepatocyte AML12 via Upregulating SMAD7. China Biotechnology, 2021, 41(7): 1-9.
链接本文:
https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2103067
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https://manu60.magtech.com.cn/biotech/CN/Y2021/V41/I7/1
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[1] |
董经宇, 李庆昌. EMT与胚胎发育及肿瘤侵袭转移. 现代肿瘤医学, 2010, 18(2):396-398.
|
|
Dong J Y, Li Q C. Roles of EMT in embryonic development and tumor metastasis. Journal of Modern Oncology, 2010, 18(2):396-398.
|
[2] |
潘琦璐, 马礼兵. 上皮-间质转化在恶性肿瘤发病和侵袭转移中的作用研究进展. 实用医学杂志, 2020, 36(17):2443-2447.
|
|
Pan Q L, Ma L B. Research progress based on the role of epithelial-mesenchymal transition in the pathogenesis and invasion of malignant tumors. The Journal of Practical Medicine, 2020, 36(17):2443-2447.
|
[3] |
胡彦建, 韩明子, 胡彦华. 上皮间质转化在原发性肝癌侵袭、转移中的作用. 胃肠病学和肝病学杂志, 2014, 23(1):117-120.
|
|
Hu Y J, Han M Z, Hu Y H. The role of epithelial-mesenchymal transition in the invasion and metastasis of pri-mary liver cancer. Chinese Journal of Gastroenterology and Hepatology, 2014, 23(1):117-120.
|
[4] |
Gheldof A, Berx G. Cadherins and epithelial-to-mesenchymal transition. Progress in Molecular Biology and Translational Science, 2013, 116:317-336.
|
[5] |
王靖思, 刘玉琴, 陈兰羽, 等. 上皮-间质转化与肝纤维化的研究进展. 世界华人消化杂志, 2014, 22(20):2857-2862.
doi: 10.11569/wcjd.v22.i20.2857
|
|
Wang J S, Liu Y Q, Chen L Y, et al. Epithelial-mesenchymal transition and hepatic fibrosis. World Chinese Journal of Digestology, 2014, 22(20):2857-2862.
doi: 10.11569/wcjd.v22.i20.2857
|
[6] |
范美玲, 应苗法, 赵蕊, 等. TGF-β信号通路在纤维化疾病中的作用研究进展. 解放军医学杂志, 2020, 45(11):1171-1177.
|
|
Fan M L, Ying M F, Zhao R, et al. Research progress on the role of TGF-β signaling pathway in fibrotic diseases. Medical Journal of Chinese People’s Liberation Army, 2020, 45(11):1171-1177.
|
[7] |
Manvar D, Pelliccia S, Regina G L, et al. New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2. European Journal of Medicinal Chemistry, 2015, 90:497-506.
doi: 10.1016/j.ejmech.2014.11.042
|
[8] |
陈永平. 浅析肝纤维化治疗现状. 现代实用医学, 2018, 30(3):281-283.
|
|
Chen Y P. Analysis of the current situation of liver fibrosis treatment. Modern Practical Medicine, 2018, 30(3):281-283.
|
[9] |
Kang Y B, Massagué J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell, 2004, 118(3):277-279.
doi: 10.1016/j.cell.2004.07.011
|
[10] |
Corso G, Figueiredo J, de Angelis S P, et al. E-cadherin deregulation in breast cancer. Journal of Cellular and Molecular Medicine, 2020, 24(11):5930-5936.
doi: 10.1111/jcmm.v24.11
|
[11] |
Jang N R, Choi J H, Gu M J. Aberrant expression of E-cadherin, N-cadherin, and P-cadherin in clear cell renal cell carcinoma: association with adverse clinicopathologic factors and poor prognosis. Applied Immunohistochemistry & Molecular Morphology, 2021, 29(3):223-230.
|
[12] |
Hassan M, Aboushousha T, El-Ahwany E, et al. Impact of E-cadherin and its transcription regulators on assessing epithelial-mesenchymal transition in chronic HCV infection. Minerva Gastroenterol Dietol, 2021, 67(2):175-182.
|
[13] |
Chapman H A. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annual Review of Physiology, 2011, 73:413-435.
doi: 10.1146/annurev-physiol-012110-142225
pmid: 21054168
|
[14] |
Park S J, Choi Y S, Lee S, et al. BIX02189 inhibits TGF-beta1-induced lung cancer cell metastasis by directly targeting TGF-beta type I receptor. Cancer Letters, 2016, 381(2):314-322.
doi: 10.1016/j.canlet.2016.08.010
|
[15] |
王靖思, 王逊, 刘玉琴, 等. 桃红芪术软肝煎基于TGF-β/SMAD信号通路逆转上皮-间质转化抗肝纤维化作用. 世界华人消化杂志, 2015, 23(13):2036-2049.
doi: 10.11569/wcjd.v23.i13.2036
|
|
Wang J S, Wang X, Liu Y Q, et al. Taohong Qizhu Ruangan Jian reverses epithelialmesenchymal transition via transforming growth factor beta/SMAD signaling pathway. World Chinese Journal of Digestology, 2015, 23(13):2036-2049.
doi: 10.11569/wcjd.v23.i13.2036
|
[16] |
Wendt M K, Allington T M, Schiemann W P. Mechanisms of the epithelial-mesenchymal transition by TGF-beta. Future Oncology (London, England), 2009, 5(8):1145-1168.
doi: 10.2217/fon.09.90
|
[17] |
Thiery J P, Acloque H, Huang R Y, et al. Epithelial-mesenchymal transitions in debelopment and disease. Cell, 2009, 139(5):871-890.
doi: 10.1016/j.cell.2009.11.007
pmid: 19945376
|
[18] |
Zhao X Y, Wu X, Qian M Q, et al. Knockdown of TGF-β1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells. Cancer Letters, 2018, 428:34-44.
doi: 10.1016/j.canlet.2018.04.026
|
[19] |
汤志杰, 张茂娜, 陈莉. 肝癌和肝纤维化发生EMT及相关信号通路的分子机制. 实用癌症杂志, 2014, 29(1):113-116.
|
|
Tang Z J, Zhang M N, Chen L. Molecular mechanism of EMT and related signal pathways in liver cancer and liver fibrosis. The Practical Journal of Cancer, 2014, 29(1):113-116.
|
[20] |
Feng F F, Li N N, Cheng P, et al. Tanshinone IIA attenuatessilica-induced pulmonary fibrosis via inhibition of TGF-beta1-SMAD signaling pathway. Biomedicine & Pharmacotherapy, 2020, 121:109586.
doi: 10.1016/j.biopha.2019.109586
|
[21] |
Higgins, Tang Y, Higgins C E, et al. TGF-beta1/p53signaling in renal fibrogenesis. Cellular Signalling, 2018, 43:1-10.
doi: 10.1016/j.cellsig.2017.11.005
|
[22] |
Chen L, Yang T, Lu D W, et al. Central role of dysregulation of TGF-beta/SMAD in CKD progression and potential targets of its treatment. Biomedicine & Pharmacotherapy, 2018, 101:670-681.
doi: 10.1016/j.biopha.2018.02.090
|
[23] |
Li N N, Feng F F, Wu K, et al. Inhibitory effects of astragaloside IV onsilica-induced pulmonary fibrosis via inactivating TGF-beta1/SMAD3signaling. Biomedicine & Pharmacotherapy, 2019, 119:109387.
doi: 10.1016/j.biopha.2019.109387
|
[24] |
Huse K, Bakkebø M, Wälchli S, et al. Role of SMAD proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS One, 2012, 7(10):e46117.
doi: 10.1371/journal.pone.0046117
|
[25] |
李戎, 常全颖, 陈罗西, 等. EMT全视角环境中艾灸加强化纤Ⅵ号方药液穴位皮肤吸收法调控肺纤维化大鼠内源性SMAD7表达以阻抑其TGF-β信号转导通路的实验研究. 四川中医, 2020, 38(9):41-46.
|
|
Li R, Chang Q Y, Chen L X, et al. Experimental study on moxibustion strengthening the acupoint skin absorption of huaxian No.6 prescription in EMT environment to regulate the expression of endogenous SMAD7 in pulmonary fibrosis rats to inhibit the TGF-β signal transduction pathway. Journal of Sichuan of Traditional Chinese Medicine, 2020, 38(9):41-46.
|
[26] |
周小凡, 赵亚南, 肖敏勤, 等. 调控SMAD7基因对瘢痕疙瘩角质形成细胞上皮-间质转化的影响. 四川大学学报(医学版), 2020, 51(6):790-796.
|
|
Zhou X F, Zhao Y N, Xiao M Q, et al. Effects of regulating SMAD7 gene on epithelial-mesenchymal transition in keloid keratinocyte. Journal of Sichuan University (Medical Science Edition), 2020, 51(6):790-796.
|
[27] |
李浩然, 李寿宁, 刘军, 等. 芹菜素通过上调SMAD-7抑制肺上皮细胞系A549细胞上皮间质转换. 临床和实验医学杂志, 2018, 17(1):44-46.
|
|
Li H R, Li S N, Liu J, et al. The inhibitory effect of apigenin on the epithelial-mesenchymal transition in the pulmonary epithelial cell line A549 by up-regulation of the SMAD-7. Journal of Clinical and Experimental Medicine, 2018, 17(1):44-46.
|
[28] |
张彦璐, 陈影, 应国清. 上皮间质转化在肿瘤侵袭转移中的研究进展. 浙江化工, 2019, 50(7):11-15.
|
|
Zhang Y L, Chen Y, Ying G Q. The research progress of epithelial-mesenchymal transition in tumor invasion and metastasis. Zhejiang Chemical Industry, 2019, 50(7):11-15.
|
[29] |
周昊, 封冰, 王锐. MicroRNA调控肝细胞癌EMT和细胞外基质重塑的研究进展. 东南国防医药, 2020, 22(3):277-282.
|
|
Zhou H, Feng B, Wang R. The research progress of microRNA to regulate EMT and extracellular matrix remodeling in hepatocellular carcinoma. Military Medical Journal of Southeast China, 2020, 22(3):277-282.
|
[30] |
苏丹, 何祖坤, 白松. 结直肠癌EMT相关LncRNA的研究进展. 实用癌症杂志, 2019, 34(11):1911-1914.
|
|
Su D, He Z K, Bai S. Research progress on colorectal cancer EMT related to LncRNA. The Practical Journal of Cancer, 2019, 34(11):1911-1914.
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