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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2021, Vol. 41 Issue (5): 105-113    DOI: 10.13523/j.cb.2101019
综述     
衣康酸发酵研究进展
高寅岭,张凤娇,赵贵众,张宏森,王风芹(),宋安东
河南农业大学生命科学学院 农业部农业微生物酶工程重点实验室 郑州 450002
Research Progress of Itaconic Acid Fermentation
GAO Yin-ling,ZHANG Feng-jiao,ZHAO Gui-zhong,ZHANG Hong-sen,WANG Feng-qin(),SONG An-dong
College of Life Sciences, Henan Agriculture University, Zhengzhou 450002, China
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摘要：

衣康酸作为一种平台化合物,可被各行业广泛用于多种高附加值产品的生产,其更是具有替代传统石油基原料的潜力,在工业生产中有着重要地位与应用前景。目前,衣康酸主要由土曲霉深层好氧发酵生产,碳源、氮源、磷酸盐、金属离子、溶解氧、pH、温度等条件对其产量影响显著。在衣康酸生产中,原料成本高是阻碍其市场进一步扩大与发展的重要因素。木质纤维素原料来源广泛、价格低廉,是理想的低成本碳源底物。研究利用木质纤维素水解液作为替代碳源生产衣康酸有望降低生产成本,对推动其发展应用具有重要意义。
关键词： 衣康酸;  土曲霉;  发酵生产;  木质纤维素    
Abstract:

Itaconic acid, a platform chemical, can be widely applied in various industries for kinds of high value-added products. It is one of the potential alternatives to the traditional petroleum-based material, which has an important position and application prospect in industrial production. At present, itaconic acid is mainly produced by submerged fermentation by Aspergillus terreus. A number of parameters have significant influence on the yield of itaconic acid, such as carbon source, nitrogen source, phosphate, metal ion, dissolved oxygen, pH, and temperature. The high cost of raw material is a crucial factor which impedes the expansion and development of the itaconic acid market in industrial production. Lignocellulose is a widely available and a promising low-cost substrate. The research of lignocellulosic hydrolysate as a substitute carbon source to produce itaconic acid is expected to reduce the production cost, which is of great significance to promote the development and application of itaconic acid.
Key words: Itaconic acid    Aspergillus terreus    Fermentation    Lignocellulose
收稿日期: 2021-01-15 出版日期: 2021-06-01
ZTFLH:  Q819  
通讯作者: 王风芹     E-mail: w_fengqin@163.com
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高寅岭
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王风芹
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引用本文:

高寅岭,张凤娇,赵贵众,张宏森,王风芹,宋安东. 衣康酸发酵研究进展[J]. 中国生物工程杂志, 2021, 41(5): 105-113.

GAO Yin-ling,ZHANG Feng-jiao,ZHAO Gui-zhong,ZHANG Hong-sen,WANG Feng-qin,SONG An-dong. Research Progress of Itaconic Acid Fermentation. China Biotechnology, 2021, 41(5): 105-113.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2101019    或    https://manu60.magtech.com.cn/biotech/CN/Y2021/V41/I5/105

Microorganism Substrate Production
/(g/L)		 Yield
/(g/g)		 Productivity
/[g/(L·h)]		 System Ref.
A. terreus NRRL 1960 glucose 130 - - BF [2]
glucose 73.6 - - BF [25]
xylose 53.97 0.63 - BF [26]
A. terreus NRRL 1962 glucose 43.5 - 0.26 SF [27]
xylose 31.6 - 0.19
arabinose 16.7 - 0.10
A. terreus DSM 23081 glucose 92.4 0.53 - SF [28]
86.5 0.54 0.62 BF
glucose 129 0.58 1.15 BF [11]
glucose 160 0.46 0.99 BF [9]
A. terreus NRRL 1971 glucose 42.6 - - SF [29]
xylose 30.5 -
mannose 36.4 0.41 -
arabinose 25.8 - -
A. terreus CECT 20365 glucose 30.2 - - SF [30]
glycerol 26.9 - -
A. terreus MJL05 glycerol 27.6 0.44 0.192 BF [31]
U. maydis MB 215 glucose 220 0.45 0.73 BF [14]
U. vetiveriae TZ1 glycerol 34.7 0.18 0.09 SF [32]
Candidia sp. B-1 glucose 35 0.35 - SF [18]
A. niger glucose 26.2 - 0.35 BF [33]
E. coli glucose 4.34 - - BF [20]
E. coli glucose 2.27 0.77 - SF [34]
32 0.68 - BF
Yarrowia lipolytica glucose 4.6 0.058 0.045 BF [23]
Corynebacterium glutamicum glucose 7.8 0.4 0.002 1 SF [35]
表1  部分已报道菌株的衣康酸产量
图1  玉米黑粉菌(a)和土曲霉(b)衣康酸代谢途径简化图([36, 38-40]) (图部分内容参考自Kuenz等[41])
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