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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2019, Vol. 39 Issue (7): 100-107    DOI: 10.13523/j.cb.20190714
综述     
链黑菌素研究进展 *
欧梦莹1,王晓政2,林双君2,关统伟1,**(),林宜锦1
1 西华大学微生物研究所 西华大学食品与生物工程学院 成都 610039
2 上海交通大学生命科学技术学院 微生物代谢国家重点实验室 上海 200240
A Review of Studies on Streptonigrin
Meng-ying OU1,Xiao-zheng WANG2,Shuang-jun LIN2,Tong-wei GUAN1,**(),Yi-jin LIN1
1 Xihua University Institute of Microbiology, School of Food Science and Biotechnology, Xihua University,Chengdu 610039,China
2 State Key Laboratory of Microbial Metabolism, School of Life Science and Technology, Shanghai Jiaotong University, Shanghai 200240,China
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摘要：

链黑菌素(streptonigrin,STN)是一种由绒毛链霉菌(Streptomyces flocculus)产生的具有独特的氨基喹啉醌式结构的高效抗肿瘤抗生素,在癌症治疗方面具有良好的防治效果和广阔的应用前景。但是,由于链黑菌素具有较为显著的骨髓抑制副作用,限制了其在临床上的广泛应用。 综述了有关链黑菌素的抗肿瘤机制、结构特点及链黑菌素及其类似物生物化学合成相关的现有知识和减除毒副作用的研究现状与展望,从而为开发低毒、无毒副作用的链黑菌素及其类似物提供科学参考。
关键词： 链黑菌素;  遗传毒性;  结构特性;  生物合成    
Abstract:

Streptonigrin (STN) is an anti-tumor antibiotic with a unique aminoquinolinium structure produced by Streptomyces flocculus, which has good control effect and broad application prospects in cancer treatment. However, the clinical application of STN has been limited because of its relatively significant myelosuppression side effect.The anti-tumor mechanism, structural features and existing knowledge related to the biosynthesis of streptonigrin and its analogs, including research status and prospects of reducing toxic side effects have been summarized, and providing a scientific reference for the development of low or non-toxic streptonigrin and its analogues.
Key words: Streptomycin    Genetic toxicity    Structural characteristics    Biosynthesis
收稿日期: 2018-12-15 出版日期: 2019-08-05
ZTFLH:  Q819  
基金资助: * 四川省科技厅资助项目(2018JZ0037)
通讯作者: 关统伟     E-mail: guantongweily@163.com
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欧梦莹
王晓政
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关统伟
林宜锦

引用本文:

欧梦莹,王晓政,林双君,关统伟,林宜锦. 链黑菌素研究进展 *[J]. 中国生物工程杂志, 2019, 39(7): 100-107.

Meng-ying OU,Xiao-zheng WANG,Shuang-jun LIN,Tong-wei GUAN,Yi-jin LIN. A Review of Studies on Streptonigrin. China Biotechnology, 2019, 39(7): 100-107.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20190714    或    https://manu60.magtech.com.cn/biotech/CN/Y2019/V39/I7/100

图1  链黑菌素家族的3个代表化合物
图2  基于同位素喂养推测的两种可能的生物合成途径
图3  链黑菌素生物合成基因簇图谱(包含55个ORF的65.5kb的序列)
图4  链黑菌素生物合成基因簇和途径
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