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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2019, Vol. 39 Issue (7): 79-84    DOI: 10.13523/j.cb.20190711
综述     
microRNA对肺癌化疗耐药性影响的研究进展 *
张潘红,李莲莲,张秀美,崔家骏,姜银杰()
宜春学院医学院 宜春 336000
Advances in the Relationship Between microRNA and Chemotherapy Resistance of Lung Cancer
Pan-hong ZHANG,Lian-lian LI,Xiu-mei ZHANG,Jia-jun CUI,Yin-jie JIANG()
Medical College ,Yichun University, Yichun 336000, China
 全文: PDF(421 KB)   HTML
摘要：

化疗耐药性是肺癌治疗的主要挑战之一,导致许多患者的化疗方案无效,并延误了接受合适治疗的时机。因此,研究肺癌化疗耐药性的机制是至关重要的。microRNA (miRNA)作为小分子片段RNA,参与了许多生命过程的调节,并在细胞耐药性产生过程中发挥重要的作用。研究表明,在化疗过程中,miRNAs可以通过降低多种药物耐药性相关基因的表达或促进细胞逃逸凋亡,参与耐药性的调节。然而,对于miRNAs介导的化疗耐药性产生机制的研究还不完善。现有研究表明,特定miRNAs的改变可能与多种癌症的获得性耐药相关,并调节肺癌细胞对化疗药物的敏感性。对miRNAs在肺癌耐药性中的作用及研究进展进行系统阐述。
关键词： 肺癌;  化疗;  化疗耐药性;  microRNA    
Abstract:

Chemotherapy resistance is one of the major challenges in the treatment of lung cancer. Chemotherapy resistance results in therapy failure and missing the opportunity of optimal therapy for some patients. Therefore, it is very important to study the mechanisms of chemotherapy resistance for lung cancer treatments. MicroRNA (miRNAs), small molecules of RNA, are involved in the regulation of various biological processes and play important roles in the therapy resistance of lung cancer. It’s shows that miRNAs regulate drug resistance by reducing the expression of multiple drug resistance-related genes or promoting cell escape apoptosis in cancer cells which treated with chemotherapeutic agents. However, the mechanism of microRNA-mediated drug resistance is not fully understood. Abnormal regulation of specific miRNAs may be associated with chemotherapy resistance to a variety of cancers, there by regulating the sensitivity of cancer cells to drugs in lung cancer. Here will systematically elaborate provide up-to-date understanding in the roles and mechanisms of miRNAs in chemotherapy resistance of lung cancer.
Key words: Lung cancer    Chemotherapy    Therapy resistance    microRNA
收稿日期: 2018-11-20 出版日期: 2019-08-05
ZTFLH:  Q819  
基金资助: * 国家自然科学基金资助项目(31660325)
通讯作者: 姜银杰     E-mail: jiangyinjie8@sina.com
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引用本文:

张潘红,李莲莲,张秀美,崔家骏,姜银杰. microRNA对肺癌化疗耐药性影响的研究进展 *[J]. 中国生物工程杂志, 2019, 39(7): 79-84.

Pan-hong ZHANG,Lian-lian LI,Xiu-mei ZHANG,Jia-jun CUI,Yin-jie JIANG. Advances in the Relationship Between microRNA and Chemotherapy Resistance of Lung Cancer. China Biotechnology, 2019, 39(7): 79-84.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20190711    或    https://manu60.magtech.com.cn/biotech/CN/Y2019/V39/I7/79

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