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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2019, Vol. 39 Issue (5): 114-119    DOI: 10.13523/j.cb.20190513
综述     
免疫佐剂分类及作用机制
杨琳,傅哲彦,吕正兵,舒建洪()
浙江理工大学生命科学学院 杭州 310018
Classification and Mechanism of Immune Adjuvant
Lin YANG,Zhe-yan FU,Zheng-bing LV,Jian-hong SHU()
Zhejiang Sci-Tech University College of Life Sciencies and Medicine, Hangzhou 310018,China
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摘要：

通过现代生物技术制成的DNA疫苗、重组疫苗和亚单位疫苗等新型疫苗,虽然安全性较传统疫苗有所提高,但其免疫原性不及传统疫苗,需要通过佐剂增强疫苗的免疫效力。随着对佐剂研究的不断深入,铝佐剂、油乳佐剂、微生物类佐剂、蜂胶佐剂、左旋咪唑佐剂、脂质体佐剂、中药佐剂及小肽类佐剂等相继问世,其作用机制也随研究的不断深入逐渐清晰。通过动物免疫实验结果发现,小肽类免疫佐剂不仅可以增强特异性免疫反应,具备免疫增强剂的功效,而且获取简单,便于运输保存,安全性高,可能是未来佐剂研究的一个主要方向。
关键词： 疫苗;  免疫佐剂;  作用机制    
Abstract:

Although new vaccines such as DNA vaccines, recombinant vaccines, and subunit vaccines obtained through modern biotechnology have been improved in safety compared to conventional vaccines, they also have certain defects. One of the biggest defects is that the immunogenicity is often low, and the efficacy of the immune body cannot be achieved. It is necessary to add an adjuvant or a carrier to improve the immune efficacy. Therefore, it is very important to develop an effective, safe and effective adjuvant to enhance the specific immune response. With the continuous development of adjuvants, aluminum adjuvant, oil emulsion adjuvant, microbial adjuvant, propolis adjuvant, levamisole adjuvant, liposome adjuvant, traditional Chinese medicine adjuvant and peptide adjuvant have been used as immunoadjuvants and its mechanism of action has also been studied more and more thoroughly. Through animal immunization experiments, it was found that peptide immunoadjuvant not only enhances specific immune response, but also has the effect of immune enhancer, and is easy to obtain, easy to transport and preserve, and has high safety, which may be a major direction of future adjuvant research.
Key words: Vaccine    Immune adjuvant    Mechanism of action
收稿日期: 2018-09-30 出版日期: 2019-06-04
ZTFLH:  Q819  
通讯作者: 舒建洪     E-mail: shujianhong@zstu.edu.cn
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引用本文:

杨琳,傅哲彦,吕正兵,舒建洪. 免疫佐剂分类及作用机制[J]. 中国生物工程杂志, 2019, 39(5): 114-119.

Lin YANG,Zhe-yan FU,Zheng-bing LV,Jian-hong SHU. Classification and Mechanism of Immune Adjuvant. China Biotechnology, 2019, 39(5): 114-119.

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https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20190513    或    https://manu60.magtech.com.cn/biotech/CN/Y2019/V39/I5/114

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