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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志  2016, Vol. 36 Issue (5): 1-11    DOI: 10.13523/j.cb.20160501
论坛     
中国工业生物技术发展态势分析与展望
陈方1, 丁陈君1, 陈云伟1, 郑颖1, 邓勇1, 徐萍2, 于建荣2, 吴林寰3, 马俊才3, 曾艳4, 刘斌4
1. 中国科学院成都文献情报中心 成都 610041;
2. 中国科学院上海生命科学信息中心 上海 200031;
3. 中国科学院微生物研究所 北京 100101;
4. 中国科学院科技促进发展局 北京 100864
A Study on the Trend and Prospective of Industrial Biotechnology in China
CHEN Fang1, DING Chen-jun1, CHEN Yun-wei1, ZHENG Ying1, DENG Yong1, XU Ping2, YU Jian-rong2, WU Lin-huan3, MA Jun-cai3, ZENG Yan4, LIU Bin4
1. Chengdu Library of Chinese Academy of Sciences, Chengdu 610041, China;
2. Shanghai Information Center for Life Sciences, Chinese Academy of Sciences, Shanghai 200031, China;
3. Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;
4. Bureau of Science and Technology for Development, Chinese Academy of Sciences, Beijing 100864, China
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摘要:

现代生物技术逐渐进入大规模产业化阶段,全球生物经济快速发展,工业生物技术作为生物经济的支柱,支撑生物制造、生物能源、生物农业、生物医药、生物环保和生物服务等产业发展。分析和展现了中国近期在工业生物技术领域基础研究、应用研究、技术转化与产业发展方面取得的进展和成就,反映了中国工业生物技术发展的现状与趋势,并提出了未来发展的挑战与机遇。

关键词: 工业生物技术生物基化学品生物经济生物产业    
Abstract:

Modern biotechnology is moving into large-scale industrialization phase, which makes global bio-economy developing rapidly. As a key pillar of bio-economy, industrial biotechnology is supporting the development of bio-manufacturing, bio-energy, bio-agriculture, bio-medicine, bio-environmental protection and biological services. The progresses and achievements of fundamental research, applied research, technology transfer and industrial development made in the field of industrial biotechnology in China recently were analyzed and demonstrated. The current situation and development trend of industrial biotechnology in China, as well the challenges and opportunities for future development were discussed.

Key words: Industrial biotechnology    Bio-based products    Bio-economy    Bioindustry
收稿日期: 2015-12-15 出版日期: 2016-01-26
ZTFLH:  Q81  
基金资助:

中国科学院知识创新工程重要方向资助项目(KSCX2-EW-G-9)

通讯作者: 丁陈君     E-mail: dingcj@clas.ac.cn
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陈方
丁陈君
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郑颖
邓勇
徐萍
于建荣
吴林寰
马俊才
曾艳
刘斌

引用本文:

陈方, 丁陈君, 陈云伟, 郑颖, 邓勇, 徐萍, 于建荣, 吴林寰, 马俊才, 曾艳, 刘斌. 中国工业生物技术发展态势分析与展望[J]. 中国生物工程杂志, 2016, 36(5): 1-11.

CHEN Fang, DING Chen-jun, CHEN Yun-wei, ZHENG Ying, DENG Yong, XU Ping, YU Jian-rong, WU Lin-huan, MA Jun-cai, ZENG Yan, LIU Bin. A Study on the Trend and Prospective of Industrial Biotechnology in China. China Biotechnology, 2016, 36(5): 1-11.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20160501        https://manu60.magtech.com.cn/biotech/CN/Y2016/V36/I5/1

[1] US NRC. Industrialization of biology: a roadmap to accelerate advanced manufacturing of chemicals.[2015-03-16]. http://www.nap.edu/openbook.php?record_id=19001.
[2] Broad Institute. DARPA awards $32 million contract to MIT, Broad Institute Foundry to bolster DNA design and manufacturing.[2015-09-24]. https://www.broadinstitute.org/news/7263, 2015-09-24.
[3] BIO-TIC.The bioeconomy enabled: A roadmap to a thriving industrial biotechnology sector in Europe.[2015-06-30].http://www.industrialbiotech-europe.eu/new/wp-content/uploads/2015/06/BIO-TIC-roadmap.pdf. 2015.
[4] Annaluru N, Muller H, Mitchell L A, et al. Total synthesis of a functional designer eukaryotic chromosome. Science, 2014, 344(6179): 55-58.
[5] Taylor A I, Pinheiro V B, Smola M J, et al. Catalysts from synthetic genetic polymers. Nature 2014, 518: 427-430.
[6] Malyshev D A, Dhami K, Lavergne T, et al. A semi-synthetic organism with an expanded genetic alphabet. Nature, 2014, 509: 385-388.
[7] Joh N H, Wang T, Bhate M P, et al. De novo design of a transmembrane Zn2+-transporting four-helix bundle. Science, 2014, 346(6216): 1520-1524.
[8] Zetsche B, Gootenberg J S, Abudayyeh O O, et al. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.[2015-09-24].http://dx.doi.org/10.1016/j.cell.2015.09.038.
[9] Galanie S, Thodey K, Trenchard I J, et al. Complete biosynthesis of opioids in yeast. Science, 2015, 349(6252): 1095-1100.
[10] Lau W, Sattely E S. Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone, Science, 2015, 349(6253): 1224-1228.
[11] Mutti F G, Knaus T, Scrutton N S, et al. Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades, Science, 2015, 349(6255): 1525-1529.
[12] Chu H S, Ahn J-H, Yun J,et al. Direct fermentation route for the production of acrylic acid. Metbolic Engineering, 2015, 32: 23-29.
[13] Chen A Y, Deng Z, Billings A N. Billings, et al. Synthesis and patterning of tunable multiscale materials with engineered cells. Nature Materials, 2014, 13: 515-523.
[14] Yan W, Song H, Song F,et al. Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme. Nature. 2015, 527: 539-543.
[15] Zhao Q, Wang M, Xu D, et al. Metabolic coupling of two small-molecule thiols programs the biosynthesis oflincomycin A. Protein design with a comprehensive statistical energy function and boosted by experimental selection for foldability.Nature, 2015, 518:115-119.
[16] Xiong P, Wang M, Zhou X, et al. Protein design with a comprehensive statistical energy function and boosted by experimental selection for foldability. Nat Commun, 2015, 5:5330.
[17] Li Y, Jiang Y, Chen H, et al. Modular construction of mammalian gene circuits using TALE transcriptional repressors. Nat Chem Biol, 2015, 11(3):207-213.
[18] Kolinko I, Lohβe A, Borg S, et al. Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene transfer. Nat Nanotechnol, 2014, 9(3):193-197.
[19] Jiang W J, Zhao X J, Gabrieli T, et al. Cas9-assisted targeting of chromosome segments CATCH enables one-step targeted cloning of large gene clusters. Nat Commun, 2015, 6:8101.
[20] Xu C, Huang R R, Teng L, et al. Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization. Nature Communications, 2015, 6:6900.
[21] Li J, Han D, Wang D, et al. Choreography of transcriptomes and lipidomes of nannochloropsis reveals the mechanisms of oil synthesis in Microalgae. Plant Cell, 2014, 26(4):1645-1665.
[22] Lina B, Fan K, Zhao J, et al. Reconstitution of TCA cycle with DAOCS to engineer Escherichia coli into an efficient whole cell catalyst of penicillin G. PNAS, 2015, 112(32):9855-9859.
[23] Linton K, Stone P, Wise J. Patenting trends & innovation in industrial biotechnology. Industrial Biotechnology. 2008, 4(4): 367-390.
[24] 中国生物发酵产业协会.中国生物发酵产业十三五规划.发酵工业网.[2015-10-13]. http://www.cn-ferment.com/news/show-10377.html. China Biotech Fermentation Industry Association, the Thirteenth five-year plan for China biotech fermentation industry. cn-ferment.com.[2015-10-13]. http://www.cn-ferment.com/news/show-10377.html.
[25] 黄辛.中国科学院上海有机所创新发展成效显著.中国科学报,2015-5-4(08-专题). Huang X. Shanghai Institute of Organic Chemistry of CAS made advances in innovation and development. Chinese Science Daily, 2015-5-4(08-Special Report).
[26] PRNewswire, Global and China Industrial Enzyme Industry Report 2014- 2017.[2015-7-2]. http://www.prnewswire.com/news-releases/global-and-china-industrial-enzyme-industry-report-2014-2017-300108412.html.
[27] 谭天伟,曹竹安,岳国君. 全球生物基产品发展集中精细化学品制造.中国战略新兴产业,2014,22:5-6. Tan T W, Cao Z A, Yue G J. Global biobased products development focus on the fine chemicals manufacturing. China Strategic Emerging Industry, 2014,22:5-6.
[28] 陈国强,王颖.中国"生物基材料"研究和产业化进展.生物工程学报,2015,31(6): 955-967. Chen G Q, Wang Y. Research and industrialization of biobased materials in China. Chin J Biotech, 2015, 31(6): 955-967.
[29] 陈祥斌.生命学院BluePHA团队问鼎第二届"校长杯"创业大赛总冠军,清华大学网站.[2015-5-23]. http://life.tsinghua.edu.cn/home/news/3212.html. Chen X B. BluePHA team in Life College won the championship of 2nd "President cup" Entrepreneurship Competition, Tsinghua University website,[2015-5-23]. http://life.tsinghua.edu.cn/home/news/3212.html.
[30] 智研咨询集团.2015-2020年中国燃料乙醇行业监测及投资前景预测报告摘要,中国产业信息网.[2015-9-1]. http://www.chyxx.com/research/201509/347354.html. Zhiyan Consulting. China's bioethanol industry monitoring and investment forecasting research 2015-2020-summary, CHII website.[2015-9-1]. http://www.chyxx.com/research/201509/347354.html.
[31] 李晓岩.我国纤维素乙醇产业化正式起步,中国化工报,[2014-10-14]. http://www.ccin.com.cn/ccin/news/2014/10/14/306105.shtml. Li X Y. Cellulosic ethanol industry started in China,China Chemical Industry News.[2014-10-14]. http://www.ccin.com.cn/ccin/news/2014/10/14/306105.shtml.
[32] 龙力生物.龙力生物"40万吨秸秆综合利用项目"签约仪式胜利召开,龙力生物网站.[2014-6-26]. http://www.longlive.cn/news_detail/newsId=720.html. Longlive Co. Longlive Co. signed the "400,000t straw integrated utilization" contract successfully. Longlive Co. website.[2014-6-26]. http://www.longlive.cn/news_detail/newsId=720.html.
[33] 王栋梁.全球最大生物乙醇新能源基地落户黑龙江,中国新闻网.[2014-8-15]. http://www.chinanews.com/df/2014/08-15/6498883.shtml. Wang D L. World biggest bioethanol fuel basement settled in Heilongjiang, ChinaNews.[2014-8-15]. http://www.chinanews.com/df/2014/08-15/6498883.shtml.
[34] 上海工业生物技术中心秸酿TM酵母走向商业化. 上海工业生物技术中心网站.[2014-8-18]. http://pudong.cibt.ac.cn/index.aspx?menuid=9&type=articleinfo&lanmuid=132&infoid=337&language=cn. Shanghai R&D Center of Industrial Biotechnology put the fast xylose-fermenting yeast to the commercial. Shanghai R&D Center of Industrial Biotechnology-website.[2014-8-18]. http://pudong.cibt.ac.cn/index.aspx?menuid=9&type=articleinfo&lanmuid=132&infoid=337&language=cn.
[35] 智研咨询集团.2015-2020年中国生物柴油行业深度调研及市场专项调研报告摘要,中国产业信息网.[2015-1-1]. http://www.chyxx.com/research/201501/304320.html. Zhiyan Consulting. China's biodiesel industry and market research 2015-2020-summary, CHII website,[2015-1-1]. http://www.chyxx.com/research/201501/304320.html.
[36] 段歆涔.从玉米秆到再生能源让生物燃料火起来.中国科学报, 2014-4-30(3版-国际). Duan X C. Frome corn stalk to renewable fuel: lightening the biofuel. Chinese Science Daily, 2014-4-30(03-International).
[37] 我国首次生物航油商业飞行顺利完成.中国青年报, 2014-3-22(02版). China completed first biofuel commercial flight. China Youth Daily, 2014-3-22(02).

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[12] 邓心安 封颖 曾海燕. 试论生物经济成长(GREW)战略[J]. 中国生物工程杂志, 2010, 30(10): 0-0.
[13] 尹军祥 李瑞国. 韩国生物产业发展现状和趋势分析[J]. 中国生物工程杂志, 2010, 30(08): 136-140.
[14] 尹军祥 李瑞国*. 日本生物产业发展现状与趋势分析[J]. 中国生物工程杂志, 2010, 30(08): 131-135.
[15] 孟广震. 打造精品学术活动,发挥学术交流主渠道作用[J]. 中国生物工程杂志, 2004, 24(9): 1-1.