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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志  2015, Vol. 35 Issue (11): 70-76    DOI: 10.13523/j.cb.20151110
综述     
自噬与癌症
景园雅1, 陈平1, 常建锋1, 陈苏1,2,3
1. 同济大学生命科学与技术学院 转化医学高等研究院 附属东方医院转化医学研究中心 上海 200092;
2. 西安交通大学医学部法医学院 西安 710061;
3. 河北省遵化市人民医院 唐山 064200
Autophagy and Cancer
JING Yuan-ya1, CHEN Ping1, CHANG Jian-feng1, CHEN Su1,2,3
1. School of Life Sciences and Technology, Advanced Institute of Translational Medicine, Research Center for Translational Medicine at East Hospital, Tongji University, Shanghai 200092, China;
2. School of Forensic Sciences, Xi'an Jiao Tong University Health Science Center, Xi'an 710061, China;
3. People's Hospital of Zunhua, Tangshan 064200, China
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摘要:

自噬是溶酶体降解途径之一,在众多真核生物细胞生理过程中发挥着重要作用。近年来,人们发现自噬对肿瘤的发生、发展过程同样具有显著的影响。自噬对肿瘤的影响具有两面性:一方面,自噬能够避免细胞遭受氧化胁迫、持续性炎症及DNA损伤的积累等,从而抑制癌症的发生;另一方面,自噬又为肿瘤细胞提供生长所需的代谢中间产物,维持肿瘤细胞内环境的稳定,进而促进肿瘤的发展。因此,自噬在肿瘤的治疗过程中同样具有正、反两方面的影响,诱导自噬:一方面能够减少放射治疗及化学治疗引起的细胞DNA损伤和染色体突变的积累,从而防止肿瘤的加剧;另一方面,肿瘤细胞又能够依赖自噬来缓解药物和射线产生的压力,从而有利于自身的存活。

关键词: 癌症发生自噬肿瘤治疗    
Abstract:

Autophagy is one of the lysosomal degradation pathways, which plays critical roles in multiple physiological processes in eukaryotes. In recent years, it has been believed that autophagy is tightly involved in tumorigenesis and development. The effects of autophagy on cancer are controversial. Autophagy prevents cells from oxidative stress, persistent inflammation, and DNA damage accumulation during carcinogenesis, and eventually inhibits the development of cancer. However, autophagy also provides growth metabolites needed for tumour cells, and maintains the balance of the intracellular environment, thus promoting carcinogenesis. Autophagy also has double-edged effects on cancer therapy: on one hand, induction of autophagy prevents the accumulation of DNA damages and mutations induced by chemotherapy or radiotherapy, and then inhibits cancer progression; on the other hand, autophagy is required for tumor cells to relieve drug and irradiation therapeutic pressures, and potentially contributes to the survival of tumor cells.

Key words: Cancer therapy    Tumorigenesis    Autophagy
收稿日期: 2015-05-13 出版日期: 2015-11-24
ZTFLH:  Q291  
基金资助:

国家自然科学基金(31201051),上海市自然科学基金(12ZR1433100,12ZR1433000),国家“973”计划(2015CB964800)资助项目

通讯作者: 陈苏     E-mail: chensu@tongji.edu.cn
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引用本文:

景园雅, 陈平, 常建锋, 陈苏. 自噬与癌症[J]. 中国生物工程杂志, 2015, 35(11): 70-76.

JING Yuan-ya, CHEN Ping, CHANG Jian-feng, CHEN Su. Autophagy and Cancer. China Biotechnology, 2015, 35(11): 70-76.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20151110        https://manu60.magtech.com.cn/biotech/CN/Y2015/V35/I11/70

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