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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志  2015, Vol. 35 Issue (4): 86-91    DOI: 10.13523/j.cb.20150413
综述     
核酸适配体结合纳米材料用于肿瘤靶向治疗
何敏瑜, 冉海涛
重庆医科大学超声影像学研究所及附属第二医院超声科 超声分子影像重庆市重点实验室 重庆 400010
Aptamer Conjugated Nanomaterials for Targeted Cancer Therapeutics
HE Min-yu, RAN Hai-tao
Institute of Ultrasound Imaging & Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University; Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing 400010, China
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摘要:

核酸适配体(aptamer)是一类由指数富集配体系统进化(systematic evolution of ligands by exponential enrichment, SELEX)技术筛选出的RNA和单链DNA寡核苷酸片段。因其非同寻常的分子识别能力及结构特性,核酸适配体已经成为最具有应用前景的生物分子之一,综述了核酸适配体结合不同的纳米材料在肿瘤靶向治疗上的应用。

关键词: 核酸适配体肿瘤靶向    
Abstract:

Aptamers is a kind of oligonucleotides which are isolated through a process termed systematic evolution of ligands by exponential enrichment. Because of its peculiar molecular recognition ability and the specific structure, aptamer is one of the most prospectly biological molecules. An overview of recent developments in aptamer nanomaterial hybrid was presented.

Key words: Aptamer    Tumor targeted
收稿日期: 2014-11-14 出版日期: 2015-04-25
ZTFLH:  Q819  
基金资助:

国家自然科学基金重点项目(81130025)、重庆市高校创新团队计划(KJTD201303)资助项目

通讯作者: 冉海涛     E-mail: rht66@163.com
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引用本文:

何敏瑜, 冉海涛. 核酸适配体结合纳米材料用于肿瘤靶向治疗[J]. 中国生物工程杂志, 2015, 35(4): 86-91.

HE Min-yu, RAN Hai-tao. Aptamer Conjugated Nanomaterials for Targeted Cancer Therapeutics. China Biotechnology, 2015, 35(4): 86-91.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20150413        https://manu60.magtech.com.cn/biotech/CN/Y2015/V35/I4/86


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