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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志  2014, Vol. 34 Issue (11): 1-8    DOI: 10.13523/j.cb.20141101
计算生物学与生物信息学专辑     
miRDOA:集数据存储与在线分析于一体的综合型microRNA数据库
李俊娥, 贾利鹃, 闫鹏程, 闫学青, 谢国云, 陈禹保
北京市计算中心 北京 100094
miRDOA:A Integrated Database of MicroRNA Include Data Storage and Online Analysis
LI Jun-e, JIA Li-juan, YAN Peng-cheng, YAN Xue-qing, XIE Guo-yun, CHEN Yu-bao
Beijing Computing Center, Beijing 100094, China
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摘要:

miRNA(microRNA)是一类小的非编码RNA,普遍存在于动物、植物等多个物种中,研究表明在原生生物以及病毒中也有miRNA。miRNA在生物的成长、发育、细胞凋亡、神经紊乱、癌症等多个方面都起到至关重要的作用,miRNA还可作为Biomarker应用于癌症等疾病的诊断和治疗。miRDOA (miRNA Database and Online Analysis)数据库存储了二百多个物种的miRNA相关信息,提供了基本的浏览和搜索功能。用户可以通过物种来浏览miRNA相关数据,也可以通过miRNA、靶基因或者序列进行检索。除此之外,miRDOA还提供了在线分析模块,主要对高通量测序数据进行初步分析,在此基础上,添加了靶基因预测、表达谱数据差异分析,以及在线BLAST功能。miRDOA是一个完全免费的开源的数据库网站,并实时更新。

关键词: miRNA高通量测序靶基因在线分析    
Abstract:

miRNA (microRNA) is a kind of small non-coding RNAs that generally exist in animals, plants, and other species. The study shows that there are miRNAs in protozoa and viruses. miRNAs play crucial roles in many biogenesis, for example, biological growth, development, cell apoptosis, neurological disorders, cancer and other aspects. miRNAs can also be used as biomarkers in the diagnosis and treatment of diseases such as cancer. miRDOA (miRNA Database and Online Analysis) is designed to retrieve and analyze sequencing data and expression profiles of miRNAs. It provides browsing and searching function for miRNAs, targetor sequences. It also provides online analysis of High-throughputsequencing data, target prediction,expression profiles analysis and online BLAST. miRDOA will be updated over time and is free available for non-commercial use atmirdoa.biocloud.org.cn.

Key words: miRNA    High-throughput sequencing    Target gene    Online analysis
收稿日期: 2014-09-20 出版日期: 2014-11-25
ZTFLH:  R318  
通讯作者: 陈禹保,chenyb@bcc.ac.cn     E-mail: chenyb@bcc.ac.cn
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引用本文:

李俊娥, 贾利鹃, 闫鹏程, 闫学青, 谢国云, 陈禹保. miRDOA:集数据存储与在线分析于一体的综合型microRNA数据库[J]. 中国生物工程杂志, 2014, 34(11): 1-8.

LI Jun-e, JIA Li-juan, YAN Peng-cheng, YAN Xue-qing, XIE Guo-yun, CHEN Yu-bao. miRDOA:A Integrated Database of MicroRNA Include Data Storage and Online Analysis. China Biotechnology, 2014, 34(11): 1-8.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20141101        https://manu60.magtech.com.cn/biotech/CN/Y2014/V34/I11/1


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