Please wait a minute...

中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2014, Vol. 34 Issue (5): 122-129    DOI: 10.13523/j.cb.20140517
讲座     
组织工程的诞生与发展——组织工程 连载之一
王佃亮
第二炮兵总医院药学部组织工程与再生医学实验室 北京 100088
The Birth and Development of Tissue Engineering
WANG Dian-liang
Tissue Engineering and Regenerative Medicine Laboratory, The Second Artillery General Hospital, Beijing 100088, China
 全文: PDF(738 KB)   HTML
摘要：

传统器官移植受到器官来源、伦理以及机体免疫排斥等方面的限制而难以满足临床治疗需要。为了应对不断的挑战，组织工程得以诞生和发展。最初组织工程的含义是联合使用细胞、支架材料和生物活性因子以促进组织的修复和再生方面的研究和应用，随着研究的深入组织工程的概念得到不断发展。现代组织工程学是一门利用工程学和生命科学的原理，研究和开发具有生物活性的人工替代物，以维持、恢复或提高人体受损组织的功能的交叉学科。自诞生20多年来，组织工程的发展大致经历了三个阶段。再生医学是现代临床医学的重要分支，与干细胞和组织工程具有密切的联系。组织工程是完美的组织器官再生，是再生医学的关键研究领域，体现了再生医学的主要发展方向。 再生医学的理论和技术方法促进了组织工程的发展。
关键词： 组织工程;  器官移植;  再生医学    
Abstract:

The traditional organ transplantation could not meet the need of the clinical treatment for the restrictions such as organ origin, ethic and body immunity. Tissue engineering therefore come to birth and proceed to grow by responding to successive challenges. At the beginning, the definition of tissue engineering was that a combined utilization of cells with scaffold materials and bioactive factors could be an efficient way to promote the research and application of tissue repair and regeneration. With the deep investigation in this field, the tissue engineering concept was also developed. Modern tissue engineering is an interdisciplinary branch of science that study and develop bioactive artificial substitution to maintain, restore or improve the function of the damaged human tissues by use of the principles of engineering science and life science. Since the birth of more than two decades, the development of tissue engineering has experienced about three stages. Regenerative medicine is an important branch science of modern clinical science, which is closely related with stem cell and tissue engineering. Tissue engineering is a perfect tissue organ regeneration, key research field of regenerative medicine, and main development direction of regenerative medicine. The principles and techniques of regenerative medicine promote the development of tissue engineering.
Key words: Organ transplantation    Regenerative Medicine    Tissue engineering
收稿日期: 2014-04-03 出版日期: 2014-05-25
ZTFLH:  Q954  
通讯作者: 王佃亮     E-mail: wangdianliang@sina.com
服务　　
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章　　

引用本文:

王佃亮. 组织工程的诞生与发展——组织工程 连载之一[J]. 中国生物工程杂志, 2014, 34(5): 122-129.

WANG Dian-liang. The Birth and Development of Tissue Engineering. China Biotechnology, 2014, 34(5): 122-129.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20140517    或    https://manu60.magtech.com.cn/biotech/CN/Y2014/V34/I5/122


[1] Toso C, Cader S, Mentha-Dugerdil A, et al. Factors predicting survival after post-transplant hepatocellular carcinoma recurrence. J Hepatobiliary Pancreat Sci, 2013, 20(3): 342-347.

[2] Soto-Gutierrez A, Wertheim J A, Ott H C, et al. Perspectives on whole-organ assembly: moving toward transplantation on demand. J Clin Invest, 2012, 122(11): 3817-3823.

[3] Lee J H, Hong S Y, Oh C K, et al. Kidney Transplantation from a donor following cardiac death supported with extracorporeal membrane oxygenation. J Korean Med Sci, 2012, 27(2): 115-119.

[4] Hollister S J, Murphy W L. Scaffold translation: barriers between concept and clinic. Tissue Eng Part B Rev, 2011, 17(6): 459-474.

[5] Ikada Y. Challenges in tissue engineering. J R Soc Interface, 2006, 3(10): 589-601.

[6] Yannas IV, Burke J F, Gordon PL,et al. Design of an artificial skin. II. Control of chemical composition. J Biomed Mater Res, 1980, 14(2):107-132.

[7] Wolter J R, Meyer R F. Sessile macrophages forming clear endothelium-like membrane on inside of successful keratoprosthesis. Trans Am Ophthalmol Soc, 1984, 82:187-202.

[8] Vacanti J P, Morse M A, Saltzman W M, et al. Selective cell transplantation using bioabsorbable artificial polymers as matrices. J Pediatr Surg, 1988, 23:3-9.

[9] Langer R, Vacanti J P. Tissue engineering. Science, 1993, 260(5110):920-926.

[10] Machingal M A, Corona B T, Walters T J, et al. A Tissue-Engineered Muscle Repair Construct for Functional Restoration of an Irrecoverable Muscle Injury in a Murine Model. Tissue Eng Part A, 2011, 17(17-18): 2291-2303.

[11] Magarian E M, Vavken P, Connolly S A, et al.Safety of intra-articular use of atelocollagen for enhanced tissue repair. Open Ortho PJ 2012, 6: 231-238.

[12] Kretlow J D, Young S, Klouda L, et al. Injectable biomaterials for regenerating complex craniofacial tissues. Adv Mater, 2009, 21(32-33): 3368-3393.

[13] Shearn J T, Kinneberg K R C, Dyment N A, et al. Tendon tissue engineering: progress, challenges, and translation to the clinic.J Musculoskelet Neuronal Interact, 2011, 11(2): 163-173.

[14] Amini A R, Laurencin C T, Nukavarapu S P.Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng 2012,40(5): 363-408.

[15] Tabata Y. Biomaterial technology for tissue engineering applications. J R Soc Interface 2009, 6(Suppl 3): S311-S324.

[16] Cima L G, Vacanti J P, Vacanti C, et al. Tissue engineering by cell transplantation using degradable polymer substrates. J Biomech Eng, 1991,113(2):143-151.

[17] Freed L E, Langer R, Martin I, et al. Tissue engineering of cartilage in space. Proc Natl Acad Sci USA, 1997,9;94(25):13885-13890.

[18] Haisch A.Ear Reconstruction through tissue engineering. Adv Otorhinolaryngol,2010, 68:108-119.

[19] Cao Y L, Vacanti J P, Paige K T, et al. Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast Reconstr Surg, 1997, 100(2):297-302.

[20] Atala A, Bauer S B, Soker S, et al. Tissue-engineered autologous bladders for patients needing cystoplasty. The Lancet, 2006, 367(9518):1241～1246

[21] Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. The Lancet, 2008,372(9655):2023-2030.

[22] Peck M, Gebhart D, Dusserre N, et al.The Evolution of vascular tissue engineering and current state of the art. Cells Tissues Organs, 2011,195(1-2): 144-158.

[23] O'Keefe R J, Mao J M.Bone Tissue Engineering and regeneration: from discovery to the clinic—an overview.Tissue Eng Part B Rev, 2011,17(6): 389-392.

[24] Tang M, Chen W, Weir M D, et al.Human embryonic stem cell-encapsulation in alginate microbeads in macroporous calcium phosphate cement for bone tissue engineering Acta Biomater,2013, 8(9): 3436-3445.

[25] Rytlewski J A, Geuss L R, Anyaeji C I, et al. Three-dimensional image quantification as a new morphometry method for tissue engineering. Tissue Eng Part C Methods, 2012, 18(7): 507-516.

[26] 陈伟,姜平. 活性真皮替代物的体内外实验. 中国组织工程研究, 2012,16(51):9607-9610. Chen W, Jiang P.In vivo and in vitro experiments of living derm substitute.Chinese Journal of Tissue Engineering Research,2012,16(51):9607-9610.

[27] 张利难,冯瑞铮,张宝林. 应用富含血小板血浆构建组织工程骨的研究. 中国当代医药, 2013, 20(23):20-23. Zhang L N,Feng R ZH,Zhang B L.The experiment of constructing tissue engineering bone with platelet-rich Plasma.China Modern Medicine.2013,20(23):20-23.

[28] 杜娟,王佃亮,张艳梅,孙晋伟. 组织工程面临的挑战与发展趋势.中国生物工程杂志, 2011,31(6):142-148. Du J,Wang D L,Zhang Y M,et al.Challenges and prospects of tissue engineering.China Biotechnology,2011,31(6):142-148.

[29] 张艳梅,王佃亮,孙晋伟.3D仿生组织工程支架及其在再生医学中的应用.解放军医学杂志, 2011,36(6):680-683.

[30] Orlando G, Wood K J, Coppi P D, et al. Regenerative medicine as applied to general surgery. Ann Surg, 2012, 255(5): 867-880.

[31] Pitt D, Aubin J M. Joseph Lister: father of modern surgery.Can J Surg, 2012, 55(5): E8-E9.

[32] Yildirim S, Fu S Y, Kim K, Zhou H, et al. Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine. Int J Oral Sci, 2011, 3(3): 107-116.

[33] King R S, Newmark P A. The cell biology of regeneration. J Cell Biol, 2012,196(5): 553-562.

[34] Martinod E, Seguin A, Radu A M, et al. Airway transplantation: a challenge for regenerative medicine. Eur J Med Res, 2013,18(1): 25.

[35] Urciuolo F, Imparato G, Totaro A, et al. Building a tissue in vitro from the bottom up: implications in regenerative medicine. Methodist Debakey Cardiovasc J, 2013, 9(4): 213-217.

[36] Khademhosseini A. Experimental approaches to tissue engineering. J Vis Exp,2007, (7): 272.

[37] Liu X Y, Chen J, Zhou Q, et al. In vitro tissue engineering of lamellar cornea using human amniotic epithelial cells and rabbit cornea stroma. Int J Ophthalmol, 2013, 6(4): 425-429.

[38] Vunjak-Novakovic G. Tissue engineering strategies for skeletal repair. HSS J, 2012, 8(1): 57-58.

[39] Khademhosseini A. Experimental approaches to tissue engineering. J Vis Exp, 2007, (7): 272.

[40] Mangera A, Chapple C R. Tissue engineering in urethral reconstruction—an update. Asian J Androl, 2013,15(1): 89-92.

[41] Tucker B, Khan W, Al-Rashid M, et al. Tissue engineering for the meniscus: a review of the literature. Open Orthop J, 2012, 6: 348-351.

[42] Orlando G, Wood K J, Coppi P D, et al. Regenerative medicine as applied to general surgery. Ann Surg, 2012, 255(5): 867-880.

[43] Carbone M, Lerut J, Neuberger J. How regenerative medicine and tissue engineering may complement the available armamentarium in gastroenterology? World J Gastroenterol, 2012,18(47): 6908-6917.

[44] Badylak S F, Nerem R M. Progress in tissue engineering and regenerative medicine. Proc Natl Acad Sci USA, 2010,107(8): 3285-3286.

[45] Nerem R M. Regenerative medicine: the emergence of an industry. J R Soc Interface, 2010, 7(Suppl 6): S771-S775.

[46] Ambrosio F, Wolf S L, Delitto A, et al. The emerging relationship between regenerative medicine and physical therapeutics. Phys Ther, 2010, 90(12): 1807-1814.

[47] Polak D J. Regenerative medicine. Opportunities and challenges: a brief overview. J R Soc Interface, 2010, 7(Suppl 6): S777-S781.

[48] Longaker M T. Jay & Margie grosfeld lecture: “regenerative medicine: a surgeon's perspective”. J Pediatr Surg, 2010, 45(1): 11-18.

[49] Astori G, Soncin S, Cicero V L, et al. Bone marrow derived stem cells in regenerative medicine as Advanced Therapy Medicinal Products. Am J Transl Res, 2010, 2(3): 285-295.

[50] Orlando G, Baptista P, Birchall M, et al. Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl Int, 2011, 24(3): 10.

[51] Song F, Li B, Stocum D L. Amphibians as research models for regenerative medicine. Organogenesis, 2010, 6(3): 141-150.

[52] Nelson T J, Behfar A, Terzic A. Strategies for therapeutic repair: the “R3” regenerative medicine paradigm. Clin Transl Sci, 2008, 1(2): 168-171.

[53] Petersen T, Niklason L. Cellular lifespan and regenerative medicine. Biomaterials, 2007,28(26): 3751-3756.

[54] Yokoo T, Fukui A, Kobayashi E. Application of regenerative medicine for kidney diseases. Organogenesis, 2007, 3(1): 34-43.

[55] 王正国. 再生医学——机遇与挑战.中华创伤杂志, 2006, 22 (1): 1-4.

[56] Raggi C, Berardi A C. Mesenchymal stem cells, aging and regenerative medicine. Muscles Ligaments Tendons J, 2012, 2(3): 239-242.

[57] Lau A N, Goodwin M, Kim C F, et al. Stem cells and regenerative medicine in lung biology and diseases. Mol Ther, 2012, 20(6): 1116-1130.

[58] Liu Z C, Chang T M S. Artificial cell Microencapsulated stem cells in regenerative medicine, tissue engineering and cell therapy. Adv Exp Med Biol, 2010, 670: 68-79.

[59] Liu Y H, Karra R, Wu S M.Cardiovascular stem cells in regenerative medicine: ready for prime time? Drug Discov Today Ther Strateg, 2008, 5(4): 201-207.

[60] McMahon D S, Thorsteinsdóttir H, Singer P A, et al. Cultivating regenerative medicine innovation in China. Regen. Med, 2010, 5(1):35-44.

[61] 付蒙,张艳梅,王佃亮,孙晋伟.人羊膜间充质干细胞的生物学特性及临床前研究.中国生物工程杂志,2011,31(12):115-119. Fu M ,Zhang Y M ,Wang D L,et al.Biological properties and preclinical studies of humanamniotic mesenchymal stem cells.China Biotechnology,2011,31(12):115-119.

[62] 张艳梅,王佃亮.再生胰腺提取物诱导人羊膜间充质干细胞定向分化为胰岛素分泌细胞.生物工程学报, 2012,28(3):214-221. Zhang Y M, Wang D L, Zeng H Y, et al. Differentiation of human amniotic mesenchymal stem cells into insulin-secreting cellsinduced by regenerating pancreatic extract. Chin J Biotech, 2012, 28(2): 214-221.

[63] 张珍,王佃亮.干细胞库研究应用进展.中国医药生物技术,2012,7(2):136-139.

[64] Logue M, Savani B N. Understanding basic steps to hematopoietic stem cell transplantation evaluation. Am J Blood Res, 2013, 3(2): 102-106.

[65] Mittal S. Stem cell research: The India perspective. Perspect Clin Res, 2013, 4(1): 105-107.
[1] 朱帅,金明杰,杨树林. 3D生物打印在软骨修复中的应用*[J]. 中国生物工程杂志, 2021, 41(5): 65-71.
[2] 宋标标,顾奇. 同轴打印小直径组织工程血管*[J]. 中国生物工程杂志, 2021, 41(10): 42-51.
[3] 余幸鸽,林开利. 基于天然水凝胶的生物材料在骨组织工程中的应用*[J]. 中国生物工程杂志, 2020, 40(5): 69-77.
[4] 王元斗,宿烽,李速明. 光交联水凝胶在组织工程中的研究进展[J]. 中国生物工程杂志, 2020, 40(4): 91-96.
[5] 苑亚坤,刘广洋,刘拥军,谢亚芳,吴昊. 间充质干细胞基础研究与临床转化的中美比较[J]. 中国生物工程杂志, 2020, 40(4): 97-107.
[6] 李玉,张晓. 日本细胞治疗监管双轨制的经验及启示 *[J]. 中国生物工程杂志, 2020, 40(1-2): 174-179.
[7] 严格,乔韡华,曹红,史嘉玮,董念国. 聚多巴胺的表面修饰功能在组织工程的应用进展*[J]. 中国生物工程杂志, 2020, 40(12): 75-81.
[8] 武慧蓉,温朝辉. 壳聚糖在神经组织工程中的应用 *[J]. 中国生物工程杂志, 2019, 39(6): 73-77.
[9] 康肸,邓爱鹏,杨树林. 壳聚糖基温敏水凝胶的研究进展[J]. 中国生物工程杂志, 2018, 38(5): 79-84.
[10] 郗来顺,云鹏,王元斗,张冠宏,邢泉生,陈阳生,宿烽. 形状记忆聚合物在组织工程中的应用 *[J]. 中国生物工程杂志, 2018, 38(12): 76-81.
[11] 孙怀远,宋晓康,廖跃华,李晓欧. 压电式微喷技术在细胞打印领域的应用*[J]. 中国生物工程杂志, 2018, 38(12): 82-90.
[12] 李大为, 何进, 何凤利, 刘雅丽, 邓旭东, 叶雅静, 尹大川. 丝素蛋白/壳聚糖复合材料在组织工程中应用的研究进展[J]. 中国生物工程杂志, 2017, 37(10): 111-117.
[13] 罗思施, 汤顺清. 琼脂糖在组织工程中的研究进展[J]. 中国生物工程杂志, 2015, 35(6): 68-74.
[14] 王佃亮. 组织器官三维构建及原位组织工程概念——组织工程连载之四[J]. 中国生物工程杂志, 2014, 34(8): 112-116.
[15] 王佃亮. 种子细胞——组织工程连载之三[J]. 中国生物工程杂志, 2014, 34(7): 108-113.
主管：中国科学院 　主办：中国科学院文献情报中心 　中国生物技术发展中心 　中国生物工程学会