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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2020, Vol. 40 Issue (10): 57-64    DOI: 10.13523/j.cb.2006033
综述     
聚多巴胺改性聚合物在神经修复中的研究进展 *
刘子儒,张甜()
武汉理工大学化学化工与生命科学学院 武汉 430070
Research Progress of Polydopamine Modified Polymers in Nerve Repair
LIU Zi-ru,ZHANG Tian()
School of Chemistry,Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070,China
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摘要：

多巴胺在碱性条件下会发生自聚合生成聚多巴胺。由于聚多巴胺具有超强黏附性能,在过去几年中其被大量应用于修饰各类生物材料。神经修复中使用的材料多为聚合物,但单独使用聚合物修复神经的效果不佳。聚多巴胺改性聚合物的亲水性和生物相容性均优于单一聚合物。除此以外,聚合物上的聚多巴胺涂层还可用于进一步修饰促进神经修复的分子。综述了聚多巴胺的合成机理、性能以及聚多巴胺改性各类聚合物在神经修复中的研究进展,并展望了该类材料的发展前景。
关键词： 聚多巴胺;  聚合物;  神经修复    
Abstract:

Inspired by the adhesion of mussels, the researchers found that dopamine self-polymerizes to form polydopamine under alkaline conditions. Due to its strong adhesion properties, polydopamine has been widely used to modify various biological materials in the past few years. Most of the materials used in nerve repair are polymers, but the effect of using polymers alone to repair nerves is not good. Polydopamine modified polymers have better hydrophilicity and biocompatibility than single polymers. In addition, the polydopamine coating on the polymer can be used to further modify the molecules that promote nerve repair. This article reviews the synthesis mechanism and performance of polydopamine and the research progress of polydopamine-modified polymers in nerve repair, and at the end of the article, the development prospects of such materials are prospected.
Key words: Polydopamine    Polymer    Nerve repair
收稿日期: 2020-06-22 出版日期: 2020-11-10
ZTFLH:  R318.08  
基金资助: * 国家中组部“青年千人计划”(40127002)
通讯作者: 张甜     E-mail: tzhang@whut.edu.cn
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刘子儒,张甜. 聚多巴胺改性聚合物在神经修复中的研究进展 *[J]. 中国生物工程杂志, 2020, 40(10): 57-64.

LIU Zi-ru,ZHANG Tian. Research Progress of Polydopamine Modified Polymers in Nerve Repair. China Biotechnology, 2020, 40(10): 57-64.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2006033    或    https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I10/57

图1  聚多巴胺改性聚合物材料示意图
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