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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2020, Vol. 40 Issue (1-2): 38-50    DOI: 10.13523/j.cb.2002103
冠状病毒药物研发与技术情报专辑     
新型冠状病毒病(COVID-19)研究进展
朱小丽1,*(),黄翠1,马丽丽1,张超2,巩玥2,赵婉雨2,赵秀芳2,郭文姣2,彭皓2,张吉1,梁慧刚1
1 中国科学院武汉文献情报中心 武汉 430071
2 中国科学院文献情报中心 北京 100190
Research Advances of Novel Coronavirus Disease (COVID-19)
ZHU Xiao-li1,*(),HUANG Cui1,MA Li-li1,ZHANG Chao2,GONG Yue2,ZHAO Wan-yu2,ZHAO Xiu-fang2,GUO Wen-jiao2,PENG Hao2,ZHANG Ji1,LIANG Hui-gang1
1 Wuhan Library, Chinese Academy of Science, Wuhan 430071, China
2 National Science Library, Chinese Academy of Sciences, Beijing 100190, China
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摘要：

2019年12月,湖北省武汉市暴发了一种由新型冠状病毒引起的肺炎(COVID-19)随后蔓延到中国所有省区以及多个国家和地区,WHO宣布其为全球关注的突发公共卫生事件。及时了解和表征该病毒对抗击疫情至关重要。通过收集和梳理该疫情暴发之后2个月内全球多领域研究人员关于COVID-19的论文,发现这些研究主要集中在溯源分析、检测手段、病患治疗、临床表现、药物研发、致病机理、传播途径、流行特征等方面。该冠状病毒与蝙蝠冠状病毒以及穿山甲冠状病毒相关,其利用与SARS-CoV相同的人受体ACE2,感染途径证实为呼吸系统和消化系统。该病毒具有人际传播能力,并且出现无症状传播。COVID-19确诊病例多数与武汉有关,大多数为轻症,年老者病死率较高。快速灵敏核酸检测通常作为确诊依据,目前已经筛选出有价值的候选药物如瑞德西韦进行临床试验。中国采取的旅行禁令和隔离等干预措施有效减轻了疫情蔓延。
关键词： COVID-19;  流行特征;  临床表现;  药物研发;  致病机理    
Abstract:

In December 2019, Wuhan, Hubei Province, an outbreak of pneumonia caused by a novel coronavirus (COVID-19) subsequently spread to all provinces and areas in China and many countries, that was declared as a Public Health Emergency of International Concern (PHEIC) by WHO. It is important to understand and characterize the virus timely to fight with the epidemic. The papers on COVID-19 by the researchers from various fields around the world within two months after the outbreak were studied and found that these studies mainly focused on traceability analysis, detection methods, patient treatment, clinical manifestations, drug development, pathogenic mechanisms, transmission ways, epidemic characteristics. The coronavirus is closely related to bat coronavirus and pangolin coronavirus. It has the same human receptor ACE2 as SARS-CoV, and the infection pathway is confirmed to be the respiratory and digestive systems. The virus indicates person-to-person and asymptomatic transmission. Most of the confirmed cases of COVID-19 are related to Wuhan, and most cases are mild, the elderly have a higher mortality rate. Rapid and sensitive nucleic acid testing is usually used as a basis for diagnosis. Currently, valuable drug candidates such as remdesivir have been screened for clinical trials. Intervention measures such as travel bans and quarantine adopted have effectively reduced the spread of the epidemic.
Key words: COVID-19    Epidemic characteristics    Clinical manifestations    Drug development    Pathogenic mechanism
收稿日期: 2020-02-24 出版日期: 2020-03-27
ZTFLH:  Q819  
通讯作者: 朱小丽     E-mail: zxl_8709@163.com
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朱小丽
黄翠
马丽丽
张超
巩玥
赵婉雨
赵秀芳
郭文姣
彭皓
张吉
梁慧刚

引用本文:

朱小丽,黄翠,马丽丽,张超,巩玥,赵婉雨,赵秀芳,郭文姣,彭皓,张吉,梁慧刚. 新型冠状病毒病(COVID-19)研究进展[J]. 中国生物工程杂志, 2020, 40(1-2): 38-50.

ZHU Xiao-li,HUANG Cui,MA Li-li,ZHANG Chao,GONG Yue,ZHAO Wan-yu,ZHAO Xiu-fang,GUO Wen-jiao,PENG Hao,ZHANG Ji,LIANG Hui-gang. Research Advances of Novel Coronavirus Disease (COVID-19). China Biotechnology, 2020, 40(1-2): 38-50.

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https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2002103    或    https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I1-2/38

图1  截至2020年2月11日学术论文所属研究领域分布
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