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Recombinant Malaria Protein rVAR2 and Its Application in Tumor-targeted Therapy |
JIANG Jin-lu1,2,PAN Hai-feng2,3,YU Si-yuan2,3,LI Ting-dong2,3,GE Sheng-xiang2,3,**() |
1 School of Life Science, National Institute of Diagnostics and Vaccine Development in Infectious Disease, Xiamen University, Xiamen 361102, China 2 Department of Laboratory Medicine, School of Public Health, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University, Xiamen 361102, China 3 Collaborative Innovation Center of Biological Products, Xiamen University, Xiamen 361102, China |
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Abstract Malignant tumor is considered to be one of the main causes of human death, and its morbidity and mortality are increasing by years. Tumor-targeted drugs can act precisely on tumors and have gained a lot of attention in recent years. Specific identification and extensive binding to tumor cells are key to achieving tumor-targeted therapy, and the lack of effective and specific pan-tumor targeting tools has greatly limited the further development of tumor-targeted therapy. Compared with existing tumor targeting approaches, Plasmodium recombinant protein rVAR2 can specifically bind Oncofetal chondroitin sulfate (ofCS), which is widely expressed on the surface of tumor cells, and has the advantage of pan-tumor targeting, providing a new idea for tumor targeting therapy. In this paper, we analyze and summarize the characteristics of rVAR2 and its progress in tumor-targeted therapy in recent years, and discuss its future development direction, in order to provide a reference for the development of clinical tumor-targeted therapy and diagnosis methods.
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Received: 03 January 2023
Published: 04 July 2023
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