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| Research Progress on the Role of Mesenchymal Stem Cell Extracellular Vesicles in Lung Diseases |
WANG Ze-hua,ZHANG Li-yun,MA Chun-yan( ) |
| Key Laboratory of Conservation and Utilization of Special Biological Resources in the Western China, Ministry of Education, College of Life Sciences, Ningxia University, Yinchuan 750021, China |
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Abstract Extracellular vesicles (EVs) are lipid vesicles naturally secreted by cells. They play an important role in communication of information in physiological and pathological processes. Mesenchymal stem cells are pluripotent stromal stem cells from a wide range of sources. The potential of mesenchymal stem cell regeneration and its ability of immunomodulation have shown great promise in the repair in and treatment of lung diseases. Mesenchymal stromal cells-EVs (MSCs-EVs) have the same functional characteristics as MSCs, and many active factors carried by MSCs-EVs have shown good therapeutic effects in lung tissue, lung microenvironment and lung diseases. In this paper, the biological characteristics of MSCs and MSCs-EVs were summarized, and the mechanism and clinical application of MSCs-EVs in pulmonary diseases were discussed.
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Received: 19 January 2023
Published: 01 June 2023
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