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| Research Progress of PLGA as Antigen Delivery System |
ZHENG Rui1,2,TU Ye-qing2,WANG Hui2,LUO De-yan2,**( ) |
1 School of Basic Medical Science, Anhui Medical University, Hefei 230032, China
2 State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medicine, Academy of Military Science, Beijing 100071, China |
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Abstract In recent years, due to the ravages of the COVID-19, the development of single-injection vaccine has attracted much attention. Traditional vaccine preparations need to be inoculated repeatedly for a period of time to produce enough neutralizing antibodies. In order to reduce the number of vaccination shots and improve people’s vaccination compliance, polymer materials have gradually entered people’s field of vision. Among them, Poly lactic-co-glycolic acid (PLGA) is one of the most studied and widely used polymer materials. As a synthetic polymer material, PLGA is easy to prepare and relatively low in price, and it has favorable sustained release characteristics and has good biosafety and histocompatibility. It has been approved by the U.S. Food and Drug Administration (FDA) as a drug delivery system, but it is in the ascendant in vaccine research and development. Based on the current research progress, this article summarizes the basic information of PLGA adjuvants and the related factors affecting their sustained release effect and immunomodulatory effects, so as to provide some ideas for subsequent vaccine preparation and research.
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Received: 20 November 2022
Published: 01 June 2023
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