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| Biological Characteristics and Application Potential of Human Amnion-derived Stem Cells |
JING Jin-peng1,ZHU Chao-jun2,3,ZHANG Zhao-hui2,3,**( ) |
1. Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2. The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China
3. Institute of TCM Ulcers, Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China |
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Abstract Stem cell transplantation has been regarded as an attractive alternative therapy in medical research and clinical trials. It is confirmed by numerous experimental model studies that stem cell transplantation can repair damaged or degraded tissues and restore their function. However, immune rejection, ethical barriers and tumorigenicity are still the difficulties in the practical applications of stem cell therapy. In recent years, perinatal stem cells have been paid increasing attention by researchers as a potential source of cells to solve the above-mentioned problems. Compared with other stem cells, human amniotic stem cells (hAMSCs) show significant advantages in these aspects. Animal experiments have found that hAMSCs have high differentiation potential and immunomodulatory activity, demonstrating great potential for the treatment of gynecological diseases, neurological diseases, kidney diseases, lung diseases, skin diseases, diabetes, cancer and other diseases. At present, with the progress of science and to meet urgent clinical needs, the clinical application of hAMSCs has gradually broken through the limitations of traditional treatment. Many clinical studies have been registered to study the effectiveness and safety of hAMSCs, and some studies have been completed as planned, which has important guiding significance for clinical practice. Therefore, this article reviews the biological research progress and application potential of hAMSCs, in order to provide theoretical basis for experimental research and clinical application of hAMSCs.
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Received: 29 September 2022
Published: 04 May 2023
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|
| [1] |
Mathew S A, Naik C, Cahill P A, et al. Placental mesenchymal stromal cells as an alternative tool for therapeutic angiogenesis. Cellular and Molecular Life Sciences, 2020, 77(2): 253-265.
doi: 10.1007/s00018-019-03268-1
pmid: 31468060
|
|
|
| [2] |
Miki T. Stem cell characteristics and the therapeutic potential of amniotic epithelial cells. American Journal of Reproductive Immunology, 2018, 80(4): e13003.
|
|
|
| [3] |
Ansari A, Denton K M, Lim R. Strategies for immortalisation of amnion-derived mesenchymal and epithelial cells. Cell Biology International, 2022, 46(12): 1999-2008.
doi: 10.1002/cbin.11892
pmid: 35998259
|
|
|
| [4] |
Muttini A, Barboni B, Valbonetti L, et al. Amniotic epithelial stem cells: salient features and possible therapeutic role. Sports Medicine and Arthroscopy Review, 2018, 26(2): 70-74.
doi: 10.1097/JSA.0000000000000189
pmid: 29722767
|
|
|
| [5] |
Borem R, Madeline A, Bowman M, et al. Differential effector response of amnion- and adipose-derived mesenchymal stem cells to inflammation; implications for intradiscal therapy. Journal of Orthopaedic Research, 2019, 37(11): 2445-2456.
doi: 10.1002/jor.24412
pmid: 31287173
|
|
|
| [6] |
Abbasi-Kangevari M, Ghamari S H, Safaeinejad F, et al. Potential therapeutic features of human amniotic mesenchymal stem cells in multiple sclerosis: immunomodulation, inflammation suppression, angiogenesis promotion, oxidative stress inhibition, neurogenesis induction, MMPs regulation, and remyelination stimulation. Frontiers in Immunology, 2019, 10: 238.
doi: 10.3389/fimmu.2019.00238
pmid: 30842772
|
|
|
| [7] |
Miki T, Strom S C. Amnion-derived pluripotent/multipotent stem cells. Stem Cell Reviews, 2006, 2(2): 133-142.
doi: 10.1007/s12015-006-0020-0
|
|
|
| [8] |
Topoluk N, Hawkins R, Tokish J, et al. Amniotic mesenchymal stromal cells exhibit preferential osteogenic and chondrogenic differentiation and enhanced matrix production compared with adipose mesenchymal stromal cells. The American Journal of Sports Medicine, 2017, 45(11): 2637-2646.
doi: 10.1177/0363546517706138
pmid: 28541092
|
|
|
| [9] |
Koike N, Sugimoto J, Okabe M, et al. Distribution of amniotic stem cells in human term amnion membrane. Microscopy, 2022, 71(1): 66-76.
doi: 10.1093/jmicro/dfab035
|
|
|
| [10] |
Yang P J, Yuan W X, Liu J, et al. Biological characterization of human amniotic epithelial cells in a serum-free system and their safety evaluation. Acta Pharmacologica Sinica, 2018, 39(8): 1305-1316.
doi: 10.1038/aps.2018.22
|
|
|
| [11] |
Wu Q Q, Fang T, Lang H X, et al. Comparison of the proliferation, migration and angiogenic properties of human amniotic epithelial and mesenchymal stem cells and their effects on endothelial cells. International Journal of Molecular Medicine, 2017, 39(4): 918-926.
doi: 10.3892/ijmm.2017.2897
pmid: 28259958
|
|
|
| [12] |
Koike C, Zhou K X, Takeda Y, et al. Characterization of amniotic stem cells. Cellular Reprogramming, 2014, 16(4): 298-305.
doi: 10.1089/cell.2013.0090
pmid: 25068631
|
|
|
| [13] |
Liu Q W, Liu Q Y, Li J Y, et al. Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure. Stem Cell Research & Therapy, 2018, 9(1): 321.
|
|
|
| [14] |
Pratama G, Vaghjiani V, Tee J Y, et al. Changes in culture expanded human amniotic epithelial cells: implications for potential therapeutic applications. PLoS One, 2011, 6(11): e26136.
|
|
|
| [15] |
Li Z H, Gong X C, Li D, et al. Intratracheal transplantation of amnion-derived mesenchymal stem cells ameliorates hyperoxia-induced neonatal hyperoxic lung injury via aminoacyl-peptide hydrolase. International Journal of Stem Cells, 2020, 13(2): 221-236.
doi: 10.15283/ijsc19110
pmid: 32323511
|
|
|
| [16] |
Akan E, Cetinkaya B, Kipmen-Korgun D, et al. Effects of amnion derived mesenchymal stem cells on fibrosis in a 5/ 6 nephrectomy model in rats. Biotechnic & Histochemistry, 2021, 96(8): 594-607.
|
|
|
| [17] |
Liu Q W, Li J Y, Zhang X C, et al. Human amniotic mesenchymal stem cells inhibit hepatocellular carcinoma in tumour-bearing mice. Journal of Cellular and Molecular Medicine, 2020, 24(18): 10525-10541.
doi: 10.1111/jcmm.v24.18
|
|
|
| [18] |
Borghesi J, Ferreira Lima M, Mario L C, et al. Canine amniotic membrane mesenchymal stromal/stem cells: isolation, characterization and differentiation. Tissue and Cell, 2019, 58: 99-106.
doi: S0040-8166(19)30054-0
pmid: 31133253
|
|
|
| [19] |
Zhang D, Yan K, Zhou J, et al. Myogenic differentiation of human amniotic mesenchymal cells and its tissue repair capacity on volumetric muscle loss. Journal of Tissue Engineering, 2019, 10: 2041731419887100.
|
|
|
| [20] |
Li Y W, Liu Z M, Jin Y, et al. Differentiation of human amniotic mesenchymal stem cells into human anterior cruciate ligament fibroblast cells by in vitro coculture. BioMed Research International, 2017, 2017: 7360354.
|
|
|
| [21] |
Kharat A, Chandravanshi B, Gadre S, et al. IGF-1 and somatocrinin trigger islet differentiation in human amniotic membrane derived mesenchymal stem cells. Life Sciences, 2019, 216: 287-294.
doi: S0024-3205(18)30733-1
pmid: 30444986
|
|
|
| [22] |
Kuang W, Liu T, He F, et al. Icariside II promotes the differentiation of human amniotic mesenchymal stem cells into dopaminergic neuron-like cells. In vitro Cellular & Developmental Biology - Animal, 2021, 57(4): 457-467.
|
|
|
| [23] |
Markmee R, Aungsuchawan S, Tancharoen W, et al. Differentiation of cardiomyocyte-like cells from human amniotic fluid mesenchymal stem cells by combined induction with human platelet lysate and 5-azacytidine. Heliyon, 2020, 6(9): e04844.
|
|
|
| [24] |
Tancharoen W, Aungsuchawan S, Markmee R, et al. The effects of human platelet lysate versus commercial endothelial growth medium on the endothelial differentiation potential of human amniotic fluid mesenchymal stem cells. Heliyon, 2020, 6(9): e04873.
|
|
|
| [25] |
Li J Y, Qiu C, Wei Y, et al. Human amniotic epithelial stem cell-derived retinal pigment epithelium cells repair retinal degeneration. Frontiers in Cell and Developmental Biology, 2021, 9: 737242.
|
|
|
| [26] |
Michalik M, Wieczorek P, Czekaj P. In vitro differentiation of human amniotic epithelial cells into hepatocyte-like cells. Cells, 2022, 11(14): 2138.
doi: 10.3390/cells11142138
|
|
|
| [27] |
Zhou Q, Liu X Y, Ruan Y X, et al. Construction of corneal epithelium with human amniotic epithelial cells and repair of limbal deficiency in rabbit models. Human Cell, 2015, 28(1): 22-36.
doi: 10.1007/s13577-014-0099-6
pmid: 25134797
|
|
|
| [28] |
Serra M, Marongiu M, Contini A, et al. Evidence of amniotic epithelial cell differentiation toward hepatic sinusoidal endothelial cells. Cell Transplantation, 2018, 27(1): 23-30.
doi: 10.1177/0963689717727541
pmid: 29562778
|
|
|
| [29] |
Yoshida Y, Takagi T, Kuramoto Y, et al. Intravenous administration of human amniotic mesenchymal stem cells in the subacute phase of cerebral infarction in a mouse model ameliorates neurological disturbance by suppressing blood brain barrier disruption and apoptosis via immunomodulation. Cell Transplantation, 2021, 30: 9636897211024183.
|
|
|
| [30] |
Hua D X, Ju Z, Gan X J, et al. Human amniotic mesenchymal stromal cells alleviate acute liver injury by inhibiting the pro-inflammatory response of liver resident macrophage through autophagy. Annals of Translational Medicine, 2019, 7(16): 392.
doi: 10.21037/atm.2019.08.83
pmid: 31555706
|
|
|
| [31] |
Pampalone M, Corrao S, Amico G, et al. Human amnion-derived mesenchymal stromal cells in cirrhotic patients with refractory ascites: a possible anti-inflammatory therapy for preventing spontaneous bacterial peritonitis. Stem Cell Reviews and Reports, 2021, 17(3): 981-998.
doi: 10.1007/s12015-020-10104-8
pmid: 33389680
|
|
|
| [32] |
Rossi D, Pianta S, Magatti M, et al. Characterization of the conditioned medium from amniotic membrane cells: prostaglandins as key effectors of its immunomodulatory activity. PLoS One, 2012, 7(10): e46956.
|
|
|
| [33] |
Gao Y, Li W R, Bu X Y, et al. Human amniotic mesenchymal stem cells inhibit aGVHD by regulating balance of Treg and T effector cells. Journal of Inflammation Research, 2021, 14: 3985-3999.
doi: 10.2147/JIR.S323054
pmid: 34429630
|
|
|
| [34] |
Wang F, Yao G P, Pan S S, et al. TIPE2-modified human amnion-derived mesenchymal stem cells promote the efficacy of allogeneic heart transplantation through inducing immune tolerance. Journal of Thoracic Disease, 2021, 13(8): 5064-5076.
doi: 10.21037/jtd-21-1034
pmid: 34527344
|
|
|
| [35] |
Tan J L, Chan S T, Wallace E M, et al. Human amnion epithelial cells mediate lung repair by directly modulating macrophage recruitment and polarization. Cell Transplantation, 2014, 23(3): 319-328.
doi: 10.3727/096368912X661409
pmid: 23294809
|
|
|
| [36] |
Li J L, Koike-Soko C, Sugimoto J, et al. Human amnion-derived stem cells have immunosuppressive properties on NK cells and monocytes. Cell Transplantation, 2015, 24(10): 2065-2076.
doi: 10.3727/096368914X685230
pmid: 25333453
|
|
|
| [37] |
Motedayyen H, Rezaei A, Zarnani A H, et al. Human amniotic epithelial cells inhibit activation and pro-inflammatory cytokines production of naive CD4+ T cells from women with unexplained recurrent spontaneous abortion. Reproductive Biology, 2018, 18(2): 182-188.
doi: S1642-431X(18)30097-4
pmid: 29729842
|
|
|
| [38] |
Wassmer C H, Berishvili E. Immunomodulatory properties of amniotic membrane derivatives and their potential in regenerative medicine. Current Diabetes Reports, 2020, 20(8): 31.
doi: 10.1007/s11892-020-01316-w
|
|
|
| [39] |
Lebreton F, Hanna R, Wassmer C H, et al. Mechanisms of immunomodulation and cytoprotection conferred to pancreatic islet by human amniotic epithelial cells. Stem Cell Reviews and Reports, 2022, 18(1): 346-359.
doi: 10.1007/s12015-021-10269-w
|
|
|
| [40] |
Magatti M, Caruso M, De Munari S, et al. Human amniotic membrane-derived mesenchymal and epithelial cells exert different effects on monocyte-derived dendritic cell differentiation and function. Cell Transplantation, 2015, 24(9): 1733-1752.
doi: 10.3727/096368914X684033
pmid: 25259480
|
|
|
| [41] |
Ling L, Feng X S, Wei T Q, et al. Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism. Stem Cell Research & Therapy, 2019, 10(1): 46.
|
|
|
| [42] |
Nigro A L, Gallo A, Bulati M, et al. Amnion-derived mesenchymal stromal/stem cell paracrine signals potentiate human liver organoid differentiation: translational implications for liver regeneration. Frontiers in Medicine, 2021, 8: 746298.
|
|
|
| [43] |
Chu Y J, Chen W P, Peng W, et al. Amnion-derived mesenchymal stem cell exosomes-mediated autophagy promotes the survival of trophoblasts under hypoxia through mTOR pathway by the downregulation of EZH2. Frontiers in Cell and Developmental Biology, 2020, 8: 545852.
|
|
|
| [44] |
Zhang J F, Li H, Yang H, et al. Human amniotic epithelial cells alleviate a mouse model of parkinson’s disease mainly by neuroprotective, anti-oxidative and anti-inflammatory factors. Journal of Neuroimmune Pharmacology, 2021, 16(3): 620-633.
doi: 10.1007/s11481-020-09969-w
|
|
|
| [45] |
Bai X C, Liu J, Yuan W X, et al. Therapeutic effect of human amniotic epithelial cells in rat models of intrauterine adhesions. Cell Transplantation, 2020, 29: 963689720908495.
|
|
|
| [46] |
Ouyang X L, You S, Zhang Y L, et al. Transplantation of human amnion epithelial cells improves endometrial regeneration in rat model of intrauterine adhesions. Stem Cells and Development, 2020, 29(20): 1346-1362.
doi: 10.1089/scd.2019.0246
|
|
|
| [47] |
Kuk N, Hodge A, Sun Y, et al. Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis. Journal of Gastroenterology and Hepatology, 2019, 34(8): 1441-1449.
doi: 10.1111/jgh.14643
pmid: 30821873
|
|
|
| [48] |
Zhang Q W, Bu S X, Sun J Y, et al. Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage. Stem Cell Research & Therapy, 2017, 8(1): 270.
|
|
|
| [49] |
Wei P, Zhong C J, Yang X L, et al. Exosomes derived from human amniotic epithelial cells accelerate diabetic wound healing via PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast function. Burns & Trauma, 2020, 8: tkaa020.
|
|
|
| [50] |
Wang X Y, Guan X H, Yu Z P, et al. Human amniotic stem cells-derived exosmal miR-181a-5p and miR-199a inhibit melanogenesis and promote melanosome degradation in skin hyperpigmentation, respectively. Stem Cell Research & Therapy, 2021, 12(1): 501.
|
|
|
| [51] |
Zhao B, Zhang Y J, Han S C, et al. Exosomes derived from human amniotic epithelial cells accelerate wound healing and inhibit scar formation. Journal of Molecular Histology, 2017, 48(2): 121-132.
doi: 10.1007/s10735-017-9711-x
pmid: 28229263
|
|
|
| [52] |
Zhang Q W, Sun J Y, Huang Y T, et al. Human amniotic epithelial cell-derived exosomes restore ovarian function by transferring microRNAs against apoptosis. Molecular Therapy - Nucleic Acids, 2019, 16: 407-418.
doi: 10.1016/j.omtn.2019.03.008
|
|
|
| [53] |
Qiu C, Ge Z, Cui W Y, et al. Human amniotic epithelial stem cells: a promising seed cell for clinical applications. International Journal of Molecular Sciences, 2020, 21(20): 7730.
doi: 10.3390/ijms21207730
|
|
|
| [54] |
Rylova Y V, Milovanova N V, Gordeeva M N, et al. Characteristics of multipotent mesenchymal stromal cells from human terminal placenta. Bulletin of Experimental Biology and Medicine, 2015, 159(2): 253-257.
doi: 10.1007/s10517-015-2935-4
pmid: 26085360
|
|
|
| [55] |
Srinivasan R C, Strom S C, Gramignoli R. Effects of cryogenic storage on human amnion epithelial cells. Cells, 2020, 9(7): 1696.
doi: 10.3390/cells9071696
|
|
|
| [56] |
Banas R A, Trumpower C, Bentlejewski C, et al. Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells. Human Immunology, 2008, 69(6): 321-328.
doi: 10.1016/j.humimm.2008.04.007
pmid: 18571002
|
|
|
| [57] |
Strom S C, Gramignoli R. Human amnion epithelial cells expressing HLA-G as novel cell-based treatment for liver disease. Human Immunology, 2016, 77(9): 734-739.
doi: 10.1016/j.humimm.2016.07.002
pmid: 27476049
|
|
|
| [58] |
Lin J S, Zhou L, Sagayaraj A, et al. Hepatic differentiation of human amniotic epithelial cells and in vivo therapeutic effect on animal model of cirrhosis. Journal of Gastroenterology and Hepatology, 2015, 30(11): 1673-1682.
doi: 10.1111/jgh.12991
|
|
|
| [59] |
Qin L J, Zhang J, Xiao Y J, et al. A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism. Journal of Molecular Cell Biology, 2022, 14(2): mjac010.
doi: 10.1093/jmcb/mjac010
|
|
|
| [60] |
Chen Y C, Lan Y W, Huang S M, et al. Human amniotic fluid mesenchymal stem cells attenuate pancreatic cancer cell proliferation and tumor growth in an orthotopic xenograft mouse model. Stem Cell Research & Therapy, 2022, 13(1): 235.
|
|
|
| [61] |
Xiang E, Han B, Zhang Q, et al. Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 2020, 11(1): 336.
|
|
|
| [62] |
Yang J Y, Chen Z Y, Pan D Y, et al. Umbilical cord-derived mesenchymal stem cell-derived exosomes combined pluronic F127 hydrogel promote chronic diabetic wound healing and complete skin regeneration. International Journal of Nanomedicine, 2020, 15: 5911-5926.
doi: 10.2147/IJN.S249129
pmid: 32848396
|
|
|
| [63] |
Li D L, Zhang J X, Liu Z J, et al. Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial-mesenchymal transition by targeting HOXC6. Stem Cell Research & Therapy, 2021, 12(1): 24.
|
|
|
| [64] |
Lu X Y, Cui J J, Cui L L, et al. The effects of human umbilical cord-derived mesenchymal stem cell transplantation on endometrial receptivity are associated with Th1/Th 2 balance change and uNK cell expression of uterine in autoimmune premature ovarian failure mice. Stem Cell Research & Therapy, 2019, 10(1): 214.
|
|
|
| [65] |
Yin N, Wu C T, Qiu J P, et al. Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8+ CD28- T cells. Stem Cell Research & Therapy, 2020, 11(1): 49.
|
|
|
| [66] |
Hendrijantini N, Hartono P. Phenotype characteristics and osteogenic differentiation potential of human mesenchymal stem cells derived from amnion membrane (HAMSCs) and umbilical cord (HUC-MSCs). Acta Informatica Medica, 2019, 27(2): 72-77.
doi: 10.5455/aim.2019.27.72-77
pmid: 31452562
|
|
|
| [67] |
Asgari H R, Akbari M, Yazdekhasti H, et al. Comparison of human amniotic, chorionic, and umbilical cord multipotent mesenchymal stem cells regarding their capacity for differentiation toward female germ cells. Cellular Reprogramming, 2017, 19(1): 44-53.
doi: 10.1089/cell.2016.0035
pmid: 28112985
|
|
|
| [68] |
Ertl J, Pichlsberger M, Tuca A C, et al. Comparative study of regenerative effects of mesenchymal stem cells derived from placental amnion, chorion and umbilical cord on dermal wounds. Placenta, 2018, 65: 37-46.
doi: S0143-4004(18)30144-9
pmid: 29908640
|
|
|
| [69] |
Dabrowski F A, Burdzinska A, Kulesza A, et al. Mesenchymal stem cells from human amniotic membrane and umbilical cord can diminish immunological response in an in vitro allograft model. Gynecologic and Obstetric Investigation, 2017, 82(3): 267-275.
doi: 10.1159/000449199
pmid: 27627653
|
|
|
| [70] |
Lim Y M, Jeong K, Lee S R, et al. Association between premature ovarian insufficiency, early menopause, socioeconomic status in a nationally representative sample from Korea. Maturitas, 2019, 121: 22-27.
doi: 10.1016/j.maturitas.2018.12.004
|
|
|
| [71] |
Ling L, Hou J Y, Liu D D, et al. Important role of the SDF-1/CXCR4 axis in the homing of systemically transplanted human amnion-derived mesenchymal stem cells (hAD-MSCs) to ovaries in rats with chemotherapy-induced premature ovarian insufficiency (POI). Stem Cell Research & Therapy, 2022, 13(1): 79.
|
|
|
| [72] |
Dreisler E, Kjer J J. Asherman’s syndrome: current perspectives on diagnosis and management. International Journal of Women’s Health, 2019, 11: 191-198.
|
|
|
| [73] |
Yu J, Zhang W W, Huang J Y, et al. Management of intrauterine adhesions using human amniotic mesenchymal stromal cells to promote endometrial regeneration and repair through notch signalling. Journal of Cellular and Molecular Medicine, 2021, 25(23): 11002-11015.
doi: 10.1111/jcmm.17023
pmid: 34724320
|
|
|
| [74] |
Liu H W, Jiang C Y, La B Y, et al. Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway. Stem Cell Research & Therapy, 2021, 12(1): 317.
|
|
|
| [75] |
Feng X S, Ling L, Zhang W Q, et al. Effects of human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation in situ on primary ovarian insufficiency in SD rats. Reproductive Sciences (Thousand Oaks, Calif), 2020, 27(7): 1502-1512.
|
|
|
| [76] |
Kim K Y, Suh Y H, Chang K A. Therapeutic effects of human amniotic epithelial stem cells in a transgenic mouse model of Alzheimer’s disease. International Journal of Molecular Sciences, 2020, 21(7): 2658.
doi: 10.3390/ijms21072658
|
|
|
| [77] |
Jiao H L, Shi K, Zhang W J, et al. Therapeutic potential of human amniotic membrane-derived mesenchymal stem cells in APP transgenic mice. Oncology Letters, 2016, 12(3): 1877-1883.
pmid: 27588134
|
|
|
| [78] |
Ferdousi F, Kondo S, Sasaki K, et al. Microarray analysis of verbenalin-treated human amniotic epithelial cells reveals therapeutic potential for Alzheimer’s disease. Aging, 2020, 12(6): 5516-5538.
doi: 10.18632/aging.v12i6
|
|
|
| [79] |
Nazarinia D, Aboutaleb N, Gholamzadeh R, et al. Conditioned medium obtained from human amniotic mesenchymal stem cells attenuates focal cerebral ischemia/reperfusion injury in rats by targeting mTOR pathway. Journal of Chemical Neuroanatomy, 2019, 102: 101707.
|
|
|
| [80] |
Tao J, Ji F, Liu B J, et al. Improvement of deficits by transplantation of lentiviral vector-modified human amniotic mesenchymal cells after cerebral ischemia in rats. Brain Research, 2012, 1448: 1-10.
doi: 10.1016/j.brainres.2012.01.069
pmid: 22386515
|
|
|
| [81] |
Kuramoto Y, Fujita M, Takagi T, et al. Early-phase administration of human amnion-derived stem cells ameliorates neurobehavioral deficits of intracerebral hemorrhage by suppressing local inflammation and apoptosis. Journal of Neuroinflammation, 2022, 19(1): 48.
doi: 10.1186/s12974-022-02411-3
pmid: 35151317
|
|
|
| [82] |
Takamiya S, Kawabori M, Yamazaki K, et al. Intravenous transplantation of amnion-derived mesenchymal stem cells promotes functional recovery and alleviates intestinal dysfunction after spinal cord injury. PLoS One, 2022, 17(7): e0270606.
|
|
|
| [83] |
Zhou H L, Fang H, Luo H T, et al. Intravenous administration of human amniotic mesenchymal stem cells improves outcomes in rats with acute traumatic spinal cord injury. Neuroreport, 2020, 31(10): 730-736.
doi: 10.1097/WNR.0000000000001473
|
|
|
| [84] |
Leaw B, Zhu D D, Tan J, et al. Human amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury. Stem Cell Research & Therapy, 2017, 8(1): 46.
|
|
|
| [85] |
Yawno T, Sabaretnam T, Li J G, et al. Human amnion epithelial cells protect against white matter brain injury after repeated endotoxin exposure in the preterm ovine fetus. Cell Transplantation, 2017, 26(4): 541-553.
doi: 10.3727/096368916X693572
pmid: 27938480
|
|
|
| [86] |
Cetinkaya B, Unek G, Kipmen-Korgun D, et al. Effects of human placental amnion derived mesenchymal stem cells on proliferation and apoptosis mechanisms in chronic kidney disease in the rat. International Journal of Stem Cells, 2019, 12(1): 151-161.
doi: 10.15283/ijsc18067
pmid: 30595007
|
|
|
| [87] |
Ren Y F, Chen Y, Zheng X Z, et al. Human amniotic epithelial cells ameliorate kidney damage in ischemia-reperfusion mouse model of acute kidney injury. Stem Cell Research & Therapy, 2020, 11(1): 410.
|
|
|
| [88] |
Lv X X, Li K, Hu Z W. Autophagy and pulmonary fibrosis. Autophagy:Biology and Diseases. Singapore: Springer Singapore, 2020: 569-579.
|
|
|
| [89] |
Cui P, Xin H M, Yao Y M, et al. Human amnion-derived mesenchymal stem cells alleviate lung injury induced by white smoke inhalation in rats. Stem Cell Research & Therapy, 2018, 9(1): 101.
|
|
|
| [90] |
Anna C, Pietro R, Patrizia B S, et al. Amniotic MSCs reduce pulmonary fibrosis by hampering lung B-cell recruitment, retention, and maturation. Stem Cells Translational Medicine, 2020, 9(9): 1023-1035.
doi: 10.1002/sctm.20-0068
pmid: 32452646
|
|
|
| [91] |
Tan J L, Lau S N, Leaw B, et al. Amnion epithelial cell-derived exosomes restrict lung injury and enhance endogenous lung repair. Stem Cells Translational Medicine, 2018, 7(2): 180-196.
doi: 10.1002/sctm.17-0185
pmid: 29297621
|
|
|
| [92] |
Royce S G, Patel K P, Mao W Y, et al. Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease. British Journal of Pharmacology, 2019, 176(13): 2195-2208.
doi: 10.1111/bph.14666
pmid: 30883698
|
|
|
| [93] |
Roehlen N, Crouchet E, Baumert T F. Liver fibrosis: mechanistic concepts and therapeutic perspectives. Cells, 2020, 9(4): 875.
doi: 10.3390/cells9040875
|
|
|
| [94] |
Hodge A, Andrewartha N, Lourensz D, et al. Human amnion epithelial cells produce soluble factors that enhance liver repair by reducing fibrosis while maintaining regeneration in a model of chronic liver injury. Cell Transplantation, 2020, 29: 963689720950221.
|
|
|
| [95] |
Pietrosi G, Fernández-Iglesias A, Pampalone M, et al. Human amniotic stem cells improve hepatic microvascular dysfunction and portal hypertension in cirrhotic rats. Liver International, 2020, 40(10): 2500-2514.
doi: 10.1111/liv.14610
pmid: 32996708
|
|
|
| [96] |
Lebreton F, Bellofatto K, Wassmer C H, et al. Shielding islets with human amniotic epithelial cells enhances islet engraftment and revascularization in a murine diabetes model. American Journal of Transplantation, 2020, 20(6): 1551-1561.
doi: 10.1111/ajt.15812
pmid: 32031745
|
|
|
| [97] |
Shu F T, Gao H J, Wu W F, et al. Amniotic epithelial cells accelerate diabetic wound healing by protecting keratinocytes and fibroblasts from high-glucose-induced senescence. Cell Biology International, 2022, 46(5): 755-770.
doi: 10.1002/cbin.v46.5
|
|
|
| [98] |
Zheng Y J, Zheng S Q, Fan X M, et al. Amniotic epithelial cells accelerate diabetic wound healing by modulating inflammation and promoting neovascularization. Stem Cells International, 2018, 2018: 1082076.
|
|
|
| [99] |
Tabatabaei M, Mosaffa N, Ghods R, et al. Vaccination with human amniotic epithelial cells confer effective protection in a murine model of Colon adenocarcinoma. International Journal of Cancer, 2018, 142(7): 1453-1466.
doi: 10.1002/ijc.31159
pmid: 29139122
|
|
|
| [100] |
Rolfo A, Giuffrida D, Giuffrida M C, et al. New perspectives for prostate cancer treatment: in vitro inhibition of LNCaP and PC 3 cell proliferation by amnion-derived mesenchymal stromal cells conditioned media. The Aging Male, 2014, 17(2): 94-101.
doi: 10.3109/13685538.2014.896894
|
|
|
| [101] |
He D, Zhao F, Jiang H, et al. LOXL2 from human amniotic mesenchymal stem cells accelerates wound epithelialization by promoting differentiation and migration of keratinocytes. Aging, 2020, 12(13): 12960-12986.
doi: 10.18632/aging.v12i13
|
|
|
| [102] |
Li J Y, Ren K K, Zhang W J, et al. Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K/AKT signaling pathway. Stem Cell Research & Therapy, 2019, 10(1): 247.
|
|
|
| [103] |
Ochiai D, Abe Y, Fukutake M, et al. Cell sheets using human amniotic fluid stem cells reduce tissue fibrosis in murine full-thickness skin wounds. Tissue and Cell, 2021, 68: 101472.
|
|
|
| [104] |
Petagna L, Antonelli A, Ganini C, et al. Pathophysiology of Crohn’s disease inflammation and recurrence. Biology Direct, 2020, 15(1): 23.
doi: 10.1186/s13062-020-00280-5
pmid: 33160400
|
|
|
| [105] |
Miyamoto S, Ohnishi S, Onishi R, et al. Therapeutic effects of human amnion-derived mesenchymal stem cell transplantation and conditioned medium enema in rats with trinitrobenzene sulfonic acid-induced colitis. American Journal of Translational Research, 2017, 9(3): 940-952.
pmid: 28386323
|
|
|
| [106] |
Ono M, Ohnishi S, Honda M, et al. Effects of human amnion-derived mesenchymal stromal cell transplantation in rats with radiation proctitis. Cytotherapy, 2015, 17(11): 1545-1559.
doi: 10.1016/j.jcyt.2015.07.003
pmid: 26256683
|
|
|
| [107] |
Thangavelu G, Du J, Paz K G, et al. Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease. Blood, 2020, 135(1): 28-40.
doi: 10.1182/blood.2019000032
pmid: 31697815
|
|
|
| [108] |
Tago Y, Kobayashi C, Ogura M, et al. Human amnion-derived mesenchymal stem cells attenuate xenogeneic graft-versus-host disease by preventing T cell activation and proliferation. Scientific Reports, 2021, 11(1): 2406.
doi: 10.1038/s41598-021-81916-y
pmid: 33510297
|
|
|
| [109] |
Sugiura R, Ohnishi S, Ohara M, et al. Effects of human amnion-derived mesenchymal stem cells and conditioned medium in rats with sclerosing cholangitis. American Journal of Translational Research, 2018, 10(7): 2102-2114.
pmid: 30093947
|
|
|
| [110] |
Liu Y H, Vaghjiani V, Tee J Y, et al. Amniotic epithelial cells from the human placenta potently suppress a mouse model of multiple sclerosis. PLoS One, 2012, 7(4): e35758.
|
|
|
| [111] |
Lim R, Malhotra A, Tan J, et al. First-in-human administration of allogeneic amnion cells in premature infants with bronchopulmonary dysplasia: a safety study. Stem Cells Translational Medicine, 2018, 7(9): 628-635.
doi: 10.1002/sctm.18-0079
pmid: 30078207
|
|
|
| [112] |
Malhotra A, Lim R, Mockler J C, et al. Two-year outcomes of infants enrolled in the first-in-human study of amnion cells for bronchopulmonary dysplasia. Stem Cells Translational Medicine, 2020, 9(3): 289-294.
doi: 10.1002/sctm.19-0251
pmid: 31774236
|
|
|
| [113] |
Lim R, Hodge A, Moore G, et al. A pilot study evaluating the safety of intravenously administered human amnion epithelial cells for the treatment of hepatic fibrosis. Frontiers in Pharmacology, 2017, 8: 549.
doi: 10.3389/fphar.2017.00549
pmid: 28878671
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