|
|
|
| Wnt/β-catenin Signal Pathway and Hepatocellular Carcinoma |
YANG Tao-hua1,CHEN Guan-yuan1,CHEN Xu1,LI Qiang1,ZHANG Qing1,WU Yue-rui2,JIANG Jian-wei3,LI Zhen-dong1,*( ) |
1. The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
2. Shunde Hospital Affiliated to Jinan University, Foshan 528306, China
3. School of Medicine, Jinan University, Guangzhou 510632, China |
|
|
|
Abstract As a common human malignant tumor, the pathogenesis of hepatocellular carcinoma (HCC) has not been completely clarified. Wnt signaling pathway is related to a variety of pathophysiological processes in human body, among which the carcinogenesis and the development of HCC may be closely related to the classic Wnt/β-catenin signaling pathway. Wnt/β-catenin regulates HCC by expressing cancer-related genes, activating hepatic stellate cells, regulating liver stem cell behavior, and promoting the invasion and metastasis of cancer cells. The role of Wnt/β-catein signaling pathway in HCC is discussed.
|
|
Received: 23 September 2022
Published: 04 May 2023
|
|
|
|
|
| [1] |
曹毛毛, 李贺, 孙殿钦, 等. 全球肝癌2020年流行病学现状. 中华肿瘤防治杂志, 2022, 29(5): 322-328.
|
|
|
| [1] |
Cao M M, Li H, Sun D Q, et al. Global epidemiology of liver cancer in 2020. Chinese Journal of Cancer Prevention and Treatment, 2022, 29(5): 322-328.
|
|
|
| [2] |
国家卫生健康委员会办公厅. 原发性肝癌诊疗指南(2022年版). 中华外科杂志, 2022, 60(4): 81-105.
|
|
|
| [2] |
General Office of the National Health Commission. Guidelines for diagnosis and treatment of primary liver cancer (2022 edition). Chinese Journal of Surgery, 2022, 60(4): 81-105.
|
|
|
| [3] |
Zhang Y, Wang X. Targeting the Wnt/β-catenin signaling pathway in cancer. Journal of Hematology & Oncology, 2020, 13(1): 165.
|
|
|
| [4] |
Ling L, Nurcombe V, Cool S M. Wnt signaling controls the fate of mesenchymal stem cells. Gene, 2009, 433(1-2): 1-7.
doi: 10.1016/j.gene.2008.12.008
pmid: 19135507
|
|
|
| [5] |
Mazzotta S, Neves C, Bonner R, et al. Distinctive roles of canonical and noncanonical Wnt signaling in human embryonic cardiomyocyte development. Stem Cell Reports, 2016, 7(4): 764-776.
doi: S2213-6711(16)30175-8
pmid: 27641648
|
|
|
| [6] |
Nusse R, Clevers H. Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell, 2017, 169(6): 985-999.
doi: S0092-8674(17)30547-0
pmid: 28575679
|
|
|
| [7] |
倪彩菊, 覃小珊, 黄赞松. Wnt/β-catenin信号通路与肝癌发生发展的研究进展. 世界华人消化杂志, 2021, 29(4): 190-196.
doi: 10.11569/wcjd.v29.i4.190
|
|
|
| [7] |
Ni C J, Qin X S, Huang Z S. Role of Wnt/β-catenin signaling pathway in occurrence and development of hepatocellular carcinoma. World Chinese Journal of Digestology, 2021, 29(4): 190-196.
doi: 10.11569/wcjd.v29.i4.190
|
|
|
| [8] |
MacDonald B T, Tamai K, He X. Wnt/β-catenin signaling: components, mechanisms, and diseases. Developmental Cell, 2009, 17(1): 9-26.
doi: 10.1016/j.devcel.2009.06.016
pmid: 19619488
|
|
|
| [9] |
Cadigan K M. Wnt/β-catenin signaling: turning the switch. Developmental Cell, 2008, 14(3): 322-323.
doi: 10.1016/j.devcel.2008.02.006
pmid: 18331712
|
|
|
| [10] |
Bisso A, Filipuzzi M, Gamarra Figueroa G P, et al. Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/taz. Hepatology, 2020, 72(4): 1430-1443.
doi: 10.1002/hep.31120
|
|
|
| [11] |
Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene, 2017, 36(11): 1461-1473.
doi: 10.1038/onc.2016.304
pmid: 27617575
|
|
|
| [12] |
Wang W H, Smits R, Hao H P, et al. Wnt/β-catenin signaling in liver cancers. Cancers, 2019, 11(7): 926.
doi: 10.3390/cancers11070926
|
|
|
| [13] |
Li J P, Gong W L, Li X X, et al. Recent progress of Wnt pathway inhibitor dickkopf-1 in liver cancer. Journal of Nanoscience and Nanotechnology, 2018, 18(8): 5192-5206.
doi: 10.1166/jnn.2018.14636
pmid: 29458569
|
|
|
| [14] |
Li S, Lavrijsen M, Bakker A, et al. Commonly observed RNF 43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers. Oncogene, 2020, 39(17): 3458-3472.
doi: 10.1038/s41388-020-1232-5
|
|
|
| [15] |
Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature, 2005, 434(7035): 843-850.
doi: 10.1038/nature03319
|
|
|
| [16] |
Moon R T, Kohn A D, De Ferrari G V, et al. WNT and β-catenin signalling: diseases and therapies. Nature Reviews Genetics, 2004, 5(9): 691-701.
doi: 10.1038/nrg1427
|
|
|
| [17] |
Luo W, Lin S C. Axin: a master scaffold for multiple signaling pathways. Neurosignals, 2004, 13(3): 99-113.
pmid: 15067197
|
|
|
| [18] |
Duda P, Akula S M, Abrams S L, et al. Targeting GSK3 and associated signaling pathways involved in cancer. Cells, 2020, 9(5): 1110.
doi: 10.3390/cells9051110
|
|
|
| [19] |
Garcia-Lezana T, Lopez-Canovas J L, Villanueva A. Signaling pathways in hepatocellular carcinoma. Advances in Cancer Research. Amsterdam: Elsevier, 2021: 63-101.
|
|
|
| [20] |
Chatterjee S, Sil P C. Targeting the crosstalks of Wnt pathway with hedgehog and notch for cancer therapy. Pharmacological Research, 2019, 142: 251-261.
doi: S1043-6618(18)31586-X
pmid: 30826456
|
|
|
| [21] |
Dey A, Varelas X, Guan K L. Targeting the hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nature Reviews Drug Discovery, 2020, 19(7): 480-494.
doi: 10.1038/s41573-020-0070-z
pmid: 32555376
|
|
|
| [22] |
Azzolin L, Panciera T, Soligo S, et al. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell, 2014, 158(1): 157-170.
doi: 10.1016/j.cell.2014.06.013
pmid: 24976009
|
|
|
| [23] |
Imajo M, Miyatake K, Iimura A, et al. A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling. The EMBO Journal, 2012, 31(5): 1109-1122.
doi: 10.1038/emboj.2011.487
|
|
|
| [24] |
Nowell C S, Radtke F. Notch as a tumour suppressor. Nature Reviews Cancer, 2017, 17(3): 145-159.
doi: 10.1038/nrc.2016.145
pmid: 28154375
|
|
|
| [25] |
Vilchez V. Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment. World Journal of Gastroenterology, 2016, 22(2): 823.
doi: 10.3748/wjg.v22.i2.823
pmid: 26811628
|
|
|
| [26] |
Collu G M, Hidalgo-Sastre A, Brennan K. Wnt-Notch signalling crosstalk in development and disease. Cellular and Molecular Life Sciences, 2014, 71(18): 3553-3567.
doi: 10.1007/s00018-014-1644-x
pmid: 24942883
|
|
|
| [27] |
Fang S, Liu M, Li L, et al. Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway. Oncogene, 2019, 38(21): 4061-4074.
doi: 10.1038/s41388-019-0704-y
pmid: 30696957
|
|
|
| [28] |
Sarkar F H, Li Y W, Wang Z W, et al. The role of nutraceuticals in the regulation of Wnt and hedgehog signaling in cancer. Cancer and Metastasis Reviews, 2010, 29(3): 383-394.
doi: 10.1007/s10555-010-9233-4
|
|
|
| [29] |
Farahmand L, Darvishi B, Majidzadeh-A K, et al. Naturally occurring compounds acting as potent anti-metastatic agents and their suppressing effects on hedgehog and WNT/β-catenin signalling pathways. Cell Proliferation, 2017, 50(1): e12299.
|
|
|
| [30] |
Mullor J L, Sánchez P, Altaba A R. Pathways and consequences: hedgehog signaling in human disease. Trends in Cell Biology, 2002, 12(12): 562-569.
pmid: 12495844
|
|
|
| [31] |
Kerekes K, Trexler M, Bányai L, et al. Wnt inhibitory factor 1 binds to and inhibits the activity of sonic hedgehog. Cells, 2021, 10(12): 3496.
doi: 10.3390/cells10123496
|
|
|
| [32] |
Luo K X. Signaling cross talk between TGF-β/smad and other signaling pathways. Cold Spring Harbor Perspectives in Biology, 2017, 9(1): a022137.
|
|
|
| [33] |
Guo X, Wang X F. Signaling cross-talk between TGF-β/BMP and other pathways. Cell Research, 2009, 19(1): 71-88.
doi: 10.1038/cr.2008.302
|
|
|
| [34] |
Patel K D, Nguyen D X. Condensing and constraining WNT by TGF-Β. Nature Cell Biology, 2021, 23(3): 213-214.
doi: 10.1038/s41556-021-00649-2
pmid: 33723426
|
|
|
| [35] |
Tomar V S, Patil V, Somasundaram K. Temozolomide induces activation of Wnt/β-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biology and Toxicology, 2020, 36(3): 273-278.
doi: 10.1007/s10565-019-09502-7
pmid: 31758290
|
|
|
| [36] |
Barzegar Behrooz A, Talaie Z, Jusheghani F, et al. Wnt and PI3K/Akt/mTOR survival pathways as therapeutic targets in glioblastoma. International Journal of Molecular Sciences, 2022, 23(3): 1353.
doi: 10.3390/ijms23031353
|
|
|
| [37] |
Suzuki M, Shigematsu H, Nakajima T, et al. Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non-small cell lung cancer. Clinical Cancer Research, 2007, 13(20):6087-6092.
doi: 10.1158/1078-0432.CCR-07-0591
|
|
|
| [38] |
Wei S, Dai M M, Zhang C, et al. KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma. Protein & Cell, 2021, 12(10): 788-809.
|
|
|
| [39] |
Dahmani R, Just P A, Perret C. The Wnt/β-catenin pathway as a therapeutic target in human hepatocellular carcinoma. Clinics and Research in Hepatology and Gastroenterology, 2011, 35(11): 709-713.
doi: 10.1016/j.clinre.2011.05.010
pmid: 21778132
|
|
|
| [40] |
Ozcan M, Altay O, Lam S, et al. Improvement in the current therapies for hepatocellular carcinoma using a systems medicine approach. Advanced Biosystems, 2020, 4(6): e2000030.
|
|
|
| [41] |
Mani S K K, Zhang H, Diab A, et al. EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. Journal of Hepatology, 2016, 65(5): 888-898.
doi: S0168-8278(16)30208-2
pmid: 27238755
|
|
|
| [42] |
Wands J R, Kim M. WNT/β-catenin signaling and hepatocellular carcinoma. Hepatology, 2014, 60(2): 452-454.
doi: 10.1002/hep.27081
pmid: 24644061
|
|
|
| [43] |
Wang L, Yao M, Fang M, et al. Expression of hepatic Wnt5a and its clinicopathological features in patients with hepatocellular carcinoma. Hepatobiliary & Pancreatic Diseases International, 2018, 17(3): 227-232.
|
|
|
| [44] |
Russell J O, Monga S P. Wnt/β-catenin signaling in liver development, homeostasis, and pathobiology. Annual Review of Pathology: Mechanisms of Disease, 2018, 13: 351-378.
doi: 10.1146/pathmechdis.2018.13.issue-1
|
|
|
| [45] |
Mavila, Thundimadathil. The emerging roles of cancer stem cells and Wnt/beta-catenin signaling in hepatoblastoma. Cancers, 2019, 11(10): 1406.
doi: 10.3390/cancers11101406
|
|
|
| [46] |
Yao Z X, Mishra L. Cancer stem cells and hepatocellular carcinoma. Cancer Biology & Therapy, 2009, 8(18): 1691-1698.
|
|
|
| [47] |
Mishra L, Banker T, Murray J, et al. Liver stem cells and hepatocellular carcinoma. Hepatology, 2009, 49(1): 318-329.
doi: 10.1002/hep.22704
pmid: 19111019
|
|
|
| [48] |
Majumdar A, Curley S A, Wu X F, et al. Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma. Nature Reviews Gastroenterology & Hepatology, 2012, 9(9): 530-538.
|
|
|
| [49] |
Yamashita T, Ji J F, Budhu A, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology, 2009, 136(3): 1012-1024.
doi: 10.1053/j.gastro.2008.12.004
pmid: 19150350
|
|
|
| [50] |
Levrero M, Zucman-Rossi J. Mechanisms of HBV-induced hepatocellular carcinoma. Journal of Hepatology, 2016, 64(1): S84-S101.
doi: 10.1016/j.jhep.2016.02.021
|
|
|
| [51] |
Lee T K W, Guan X Y, Ma S. Cancer stem cells in hepatocellular carcinoma: from origin to clinical implications. Nature Reviews Gastroenterology & Hepatology, 2022, 19(1): 26-44.
|
|
|
| [52] |
Yamashita T, Budhu A, Forgues M, et al. Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Research, 2007, 67(22): 10831-10839.
doi: 10.1158/0008-5472.CAN-07-0908
pmid: 18006828
|
|
|
| [53] |
Wang C, Yang W, Yan H X, et al. Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine-treated HBx transgenic mice. Hepatology (Baltimore, Md), 2012, 55(1): 108-120.
doi: 10.1002/hep.24675
|
|
|
| [54] |
Gurzu S, Kobori L, Fodor D, et al. Epithelial mesenchymal and endothelial mesenchymal transitions in hepatocellular carcinoma: a review. BioMed Research International, 2019, 2019: 2962580.
|
|
|
| [55] |
Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nature Reviews Molecular Cell Biology, 2014, 5(3): 178-196.
|
|
|
| [56] |
张青云, 傅俊江, 陈汉春. 上皮间质转化介导肿瘤转移的分子机制. 生命科学研究, 2018, 22(6): 503-510.
|
|
|
| [56] |
Zhang Q Y, Fu J J, Chen H C. The molecular mechanism of epithelial-mesenchymal transition mediating tumor metastasis. Life Science Research, 2018, 22(6): 503-510.
|
|
|
| [57] |
Jin Y J, Wu D, Yang W W, et al. Hepatitis B virus x protein induces epithelial-mesenchymal transition of hepatocellular carcinoma cells by regulating long non-coding RNA. Virology Journal, 2017, 14(1): 238.
doi: 10.1186/s12985-017-0903-5
pmid: 29258558
|
|
|
| [58] |
Miao C G, Yang Y Y, He X, et al. Wnt signaling in liver fibrosis: progress, challenges and potential directions. Biochimie, 2013, 95(12): 2326-2335.
doi: 10.1016/j.biochi.2013.09.003
|
|
|
| [59] |
Miao C G, Yang Y Y, He X, et al. Wnt signaling in liver fibrosis: progress, challenges and potential directions. Biochimie, 2013, 95(12): 2326-2335.
doi: 10.1016/j.biochi.2013.09.003
|
|
|
| [60] |
Yao B W, Li Y Z, Wang L, et al. MicroRNA-3194-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by decreasing Wnt/β-catenin signaling through targeting BCL9. Artifical Cells, Nanomedicine, and Biotechnology, 2019, 47(1): 3885-3895.
|
|
|
| [61] |
Wu S S, Chen S, Lin N, et al. Long non-coding RNA SUMO1P 3 promotes hepatocellular carcinoma progression through activating Wnt/β-catenin signalling pathway by targeting miR-320a. Journal of Cellular and Molecular Medicine, 2020, 24(5): 3108-3116.
doi: 10.1111/jcmm.v24.5
|
|
|
| [62] |
Zhang N B, Chen X. A positive feedback loop involving the LINC00346/β-catenin/MYC axis promotes hepatocellular carcinoma development. Cellular Oncology, 2020, 43(1): 137-153.
doi: 10.1007/s13402-019-00478-4
pmid: 31691159
|
|
|
| [63] |
Wang H L, Ou J R, Jian Z X, et al. MiR-186 modulates hepatocellular carcinoma cell proliferation and mobility via targeting MCRS1-mediated Wnt/β-catenin signaling. Journal of Cellular Physiology, 2019, 234(12): 23135-23145.
doi: 10.1002/jcp.28878
pmid: 31140612
|
|
|
| [64] |
Ma Y K, Shen T H, Yang X Y. Upregulation of LncRNA FAM83H-AS1 in hepatocellular carcinoma promotes cell proliferation, migration and invasion by Wnt/β-catenin pathway. European Review for Medical and Pharmacological Sciences, 2019, 23(18): 7855-7862.
doi: 18995
pmid: 31599410
|
|
|
| [65] |
Zhang X D, Xu X L, Zhang Z C, et al. Linc-KILH potentiates Notch 1 signaling through inhibiting KRT19 phosphorylation and promotes the malignancy of hepatocellular carcinoma. International Journal of Biological Sciences, 2021, 17(3): 768-780.
doi: 10.7150/ijbs.52279
|
|
|
| [66] |
Tan A C, Li Q X, Chen L Z. CircZFR promotes hepatocellular carcinoma progression through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/β-catenin pathway. Archives of Biochemistry and Biophysics, 2019, 661: 196-202.
doi: S0003-9861(18)30674-X
pmid: 30468709
|
|
|
| [67] |
Kong S Z, Xue H, Li Y C, et al. The long noncoding RNA OTUD6B-AS 1 enhances cell proliferation and the invasion of hepatocellular carcinoma cells through modulating GSKIP/Wnt/β-catenin signalling via the sequestration of miR-664b-3p. Experimental Cell Research, 2020, 395(1): 112180.
|
|
|
| [68] |
Huang G Q, Liang M, Liu H Y, et al. CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway. Cell Death & Disease, 2020, 11(12): 1-14.
|
|
|
| [69] |
Yang B M, Zhao J R, Huo T T, et al. Effects of CircRNA-ITCH on proliferation and apoptosis of hepatocellular carcinoma cells through inhibiting Wnt/β-catenin signaling pathway. Journal of BUON, 2020, 25(3): 1368-1374.
pmid: 32862578
|
|
|
| [70] |
Xin R Q, Li W B, Hu Z W, et al. MiR-329-3p inhibits hepatocellular carcinoma cell proliferation and migration through USP22-Wnt/β-Catenin pathway. European Review for Medical Pharmacological Sciences, 2020, 24(19): 9932-9939.
|
|
|
| [71] |
Wang X L, Shi M, Xiang T, et al. Long noncoding RNA DGCR5 represses hepatocellular carcinoma progression by inactivating Wnt signaling pathway. Journal of Cellular Biochemistry, 2019, 120(1): 275-282.
doi: 10.1002/jcb.v120.1
|
|
|
| [72] |
Tang H, Zhao H, Yu Z Y, et al. MicroRNA-194 inhibits cell invasion and migration in hepatocellular carcinoma through PRC1-mediated inhibition of Wnt/β-catenin signaling pathway. Digestive and Liver Disease, 2019, 51(9): 1314-1322.
doi: S1590-8658(19)30098-2
pmid: 30948333
|
|
|
| [73] |
Han W J, Wang Q H, Zheng L S, et al. The role of lncRNA ANRIL in the progression of hepatocellular carcinoma. The Journal of Pharmacy and Pharmacology, 2021, 73(8): 1033-1038.
doi: 10.1093/jpp/rgaa047
|
|
|
| [74] |
Gao J, Dai C, Yu X, et al. MicroRNA-485-5p inhibits the progression of hepatocellular carcinoma through blocking the WBP2/Wnt signaling pathway. Cellular Signalling, 2020, 66: 109466.
|
|
|
| [75] |
Chi X B, Jiang Y, Chen Y B, et al. MicroR-505/heterogeneous nuclear ribonucleoprotein M inhibits hepatocellular carcinoma cell proliferation and induces cell apoptosis through the Wnt/β-catenin signaling pathway. Biomarkers in Medicine, 2020, 14(11): 981-996.
doi: 10.2217/bmm-2019-0511
pmid: 32940078
|
|
|
| [76] |
Li D D, Zhang J W, Yang J, et al. CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling pathway and epithelial-to-mesenchymal transition. Cell Death & Disease, 2022, 13(1): 12.
|
|
|
| [77] |
Hu X B, Wang R F, Ren Z G, et al. MiR-26b suppresses hepatocellular carcinoma development by negatively regulating ZNRD1 and Wnt/β-catenin signaling. Cancer Medicine, 2019, 8(17): 7359-7371.
doi: 10.1002/cam4.2613
pmid: 31637871
|
|
|
| [78] |
戴美琴, 蔡茁, 陈娜娜, 等. 苦参碱通过调控β-catenin信号通路抑制肝癌细胞干性. 南方医科大学学报, 2019, 39(10): 1239-1245.
|
|
|
| [78] |
Dai M Q, Cai Z, Chen N N, et al. Matrine suppresses stemness of hepatocellular carcinoma cells by regulating β-catenin signaling pathway. Journal of Southern Medical University, 2019, 39(10): 1239-1245.
|
|
|
| [79] |
Yin H S, Que R S, Liu C Y, et al. Survivin-targeted drug screening platform identifies a matrine derivative WM-127 as a potential therapeutics against hepatocellular carcinoma. Cancer Letters, 2018, 425: 54-64.
doi: S0304-3835(18)30247-7
pmid: 29608986
|
|
|
| [80] |
朱云, 李成, 林鑫盛, 等. 白术多糖对肝癌细胞增殖及侵袭的抑制作用及其机制. 南方医科大学学报, 2019, 39(10): 1180-1185.
|
|
|
| [80] |
Zhu Y, Li C, Lin X S, et al. Effect of Atractylodes macrocephala polysaccharide on proliferation and invasion of hepatocellular carcinoma cells in vitro. Journal of Southern Medical University, 2019, 39(10): 1180-1185.
|
|
|
| [81] |
Zeyada M S, Abdel-Rahman N, El-Karef A, et al. Niclosamide-loaded polymeric micelles ameliorate hepatocellular carcinoma in vivo through targeting Wnt and Notch pathways. Life Sciences, 2020, 261: 118458.
|
|
|
| [82] |
Tan H Y, Wang N, Li S, et al. Repression of WT1-mediated LEF 1 transcription by mangiferin governs β-catenin-independent Wnt signalling inactivation in hepatocellular carcinoma. Cellular Physiology and Biochemistry, 2018, 47(5): 1819-1834.
doi: 10.1159/000491063
|
|
|
| [83] |
Pan F F, Zheng Y B, Shi C J, et al. H19-Wnt/β-catenin regulatory axis mediates the suppressive effects of apigenin on tumor growth in hepatocellular carcinoma. European Journal of Pharmacology, 2021, 893: 173810.
|
|
|
| [84] |
Kang Q Z, Gong J, Wang M F, et al. 6-C-(E-phenylethenyl)naringenin attenuates the stemness of hepatocellular carcinoma cells by suppressing Wnt/β-catenin signaling. Journal of Agricultural and Food Chemistry, 2019, 67(50): 13939-13947.
doi: 10.1021/acs.jafc.9b05733
pmid: 31769973
|
|
|
| [85] |
Gong T, Ning X, Deng Z Y, et al. Propofol-induced miR-219-5p inhibits growth and invasion of hepatocellular carcinoma through suppression of GPC3-mediated Wnt/β-catenin signalling activation. Journal of Cellular Biochemistry, 2019, 120(10): 16934-16945.
doi: 10.1002/jcb.28952
pmid: 31104336
|
|
|
| [86] |
Liao S T, Chen H Y, Liu M, et al. Aquaporin 9 inhibits growth and metastasis of hepatocellular carcinoma cells via Wnt/β-catenin pathway. Aging, 2020, 12(2): 1527-1544.
doi: 10.18632/aging.v12i2
|
|
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
