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Biosafety Risks and Countermeasures of Active Substance in Synthesis Biology |
NING Jun-tao1,ZOU Shi-shi2,ZUO Kun-lan3,WU Zong-zhen3,Li Jing4,XU Yan-long5,LIU Huan3,6,**() |
1 Intellectual Property Development & Research Center, China National Intellectual Property Administration, Beijing 100088, China 2 Wuhan University, Wuhan 430072, China 3 School of Humanities and Social Sciences, University of Science and Technology of China, Hefei 230026, China 4 Office of Laboratory Management, Chinese Center for Disease Control and Prevention, Beijing 102206, China 5 College of Humanities, University of Chinese Academy of Sciences, Beijing 100049, China 6 Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China |
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Abstract Active substances are often synthesized by microorganisms as carriers in biological metabolic engineering at all times, and the formation of metabolites in all stages of the life system provides a natural template and design blueprint for the development of synthetic biotechnology. If these metabolites involve harmful active substances or potential safety threats, such as toxins and protein complexes that are toxic to humans, animals and plants, drug molecules and their derivatives that can be used for clinical treatment and can also lead to dysfunction and health hazards, and chemicals that are prohibited or restricted by international conventions, they will have adverse effects on biosafety. Through reviewing and analyzing the safety risks in synthetic biology related to active substances such as natural metabolic pathway biosynthetic active substances, non-natural metabolic pathway biosynthetic active substances, chemosynthetic active substances and active substance delivery technology, this paper puts forward countermeasure strategy for promoting the innovative development and application fields of active substances in synthetic biology.
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Received: 26 September 2022
Published: 31 March 2023
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Corresponding Authors:
**Huan LIU
E-mail: liuhuan520@ustc.edu.cn
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