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Research Progress and Predictive Analysis of Quality Markers of Angelica Medicinal Plants in China |
LI Sheng-shuo1,2,3,LI Jia1,2,3,KANG Shu-he1,2,3,**(),GUO Jin-wang1,2,3,ZHAN Meng-ru1,2,3 |
1 School of Chemical Engineering, Northwest Minzu University, Lanzhou 730106,China 2 Key Laboratory of Environment-Friendly Composites of the State Ethnic Affairs Commission, Lanzhou 730106, China 3 Gansu Provincial Biomass Function Composites Engineering Research Center,Lanzhou 730106, China |
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Abstract Chinese Angelica plants have rich plant resources, including 34 kinds of herbs such as Angelica, Angelica dahurica, and Angelicae Pubescentis Radix, widely used clinically and have high medicinal value. They are rich in coumarin, polysaccharide, organic acid, phenol, and naphtha. In addition to their traditional effects of replenishing the blood supply and invigorating the circulation of blood, regulating the menstrual cycle and relieving pain in the lower abdomen, and moistening intestines to relieve constipation, they also have anti-oxidation, anti-aging, neuron-protection, anti-tumor and other pharmacological effects. They have a broad application prospect. In this paper, the distribution, medicinal efficacy, chemical composition and pharmacological effect of Chinese Angelica plants were reviewed, which can provide reference for the development and utilization of Angelica plants. According to the concept of Q-marker, the factors affecting the quality of Chinese Angelica plants can be summarized as the varieties of medicinal plants, plant production areas, chemical components, processing methods, traditional efficacy and online pharmacology prediction and analysis. In order to provide reference for establishing and improving their quality control and evaluation methods, this paper analyzed and discussed the Chinese Angelica plants from different aspects.
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Received: 03 September 2022
Published: 07 December 2022
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|
[1] |
国家药典委员会. 中华人民共和国药典一部:2020年版. 北京: 中国医药科技出版社, 2020:133.
|
|
|
[1] |
Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China 2020(Volume 1). Beijing: China Medical Science Press, 2020: 133.
|
|
|
[2] |
中国科学院中国植物志委员会. 中国植物志第五十五卷第三分册. 北京: 科学出版社, 1992.
|
|
|
[2] |
Delectis Flora Reipublicae Popularis Sinicae Agendae Academiae Sinicae Edtta.Flora of China. Flora reipubligae popularis sinicae. Tomus 55 (3). Beijing: Science Press, 1992.
|
|
|
[3] |
舒璞, 佘孟兰. 中国伞形科植物花粉图志. 上海: 上海科学技术出版社, 2001.
|
|
|
[3] |
Shu P, She M L. Pollen Photographs and Flora of Umbelliferae in China. Shanghai: Shanghai Scientific & Technical Publishers, 2001.
|
|
|
[4] |
Niu X W, Zhang J J, Ni J R, et al. Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. Bioscience Reports, 2018, 38(6): BSR20180519.
doi: 10.1042/BSR20180519
|
|
|
[5] |
冯慧敏, 李玥, 罗旭东, 等. 当归化学成分和药理作用研究进展及质量标志物的预测分析. 中华中医药学刊, 2022, 40(4): 159-166.
|
|
|
[5] |
Feng H M, Li Y, Luo X D, et al. Research progress on chemical constituents and pharmacological effects of danggui (Radix Angelicae sinensis) and prediction analysis on its quality markers full text replacement. Chinese Archives of Traditional Chinese Medicine, 2022, 40(4): 159-166.
|
|
|
[6] |
Liu W J, Li W Y, Sui Y, et al. Structure characterization and anti-leukemia activity of a novel polysaccharide from Angelica sinensis (Oliv.) Diels. International Journal of Biological Macromolecules, 2019, 121: 161-172.
doi: 10.1016/j.ijbiomac.2018.09.213
|
|
|
[7] |
周桂生, 杨念云, 唐于平, 等. 当归地上部分的化学成分及其生物活性研究(英文). 中国天然药物, 2012, 10(4): 295-298.
|
|
|
[7] |
Zhou G S, Yang N Y, Tang Y P, et al. Chemical constituents from the aerial parts of Angelica sinensis and their bioactivities. Chinese Journal of Natural Medicines, 2012, 10(4): 295-298.
|
|
|
[8] |
刘方舟, 杨阳, 李萌, 等. 基于网络药理学研究陇产当归挥发油类成分多维药理的作用机制. 世界中医药, 2022, 17(16): 2258-2262, 2269.
|
|
|
[8] |
Liu F Z, Yang Y, Li M, et al. Pharmacological mechanism of the essential oil compounds from Angelica sinensis in Gansu Province by network pharmacology. World Chinese Medicine, 2022, 17(16): 2258-2262, 2269.
|
|
|
[9] |
李曦, 张丽宏, 王晓晓, 等. 当归化学成分及药理作用研究进展. 中药材, 2013, 36(6): 1023-1028.
|
|
|
[9] |
Li X, Zhang L H, Wang X X, et al. Research progress on chemical constituents and pharmacological effects of Angelica sinensis. Journal of Chinese Medicinal Materials, 2013, 36(6): 1023-1028.
|
|
|
[10] |
刘露丝, 彭成, 熊亮. 当归苯酞类化合物的研究进展. 世界科学技术:中医药现代化, 2015, 17(5): 958-962.
|
|
|
[10] |
Liu L S, Peng C, Xiong L. Research progress on phthalides from Angelica sinensis. Modernization of Traditional Chinese Medicine and Materia Medica:World Science and Technology, 2015, 17(5): 958-962.
|
|
|
[11] |
赵雪娇, 王海峰, 赵丹奇, 等. 当归化学成分的分离与鉴定. 沈阳药科大学学报, 2013, 30(3): 182-185, 221.
|
|
|
[11] |
Zhao X J, Wang H F, Zhao D Q, et al. Isolation and identification of the chemical constituents from roots of Angelica sinensis(Oliv.)Diels. Journal of Shenyang Pharmaceutical University, 2013, 30(3): 182-185, 221.
|
|
|
[12] |
Tabanca N, Gao Z P, Demirci B, et al. Molecular and phytochemical investigation of Angelica dahurica and Angelica pubescentis essential oils and their biological activity against Aedes aegypti, Stephanitis pyrioides, and Colletotrichum species. Journal of Agricultural and Food Chemistry, 2014, 62(35): 8848-8857.
doi: 10.1021/jf5024752
|
|
|
[13] |
艾青青, 高必兴, 兰志琼, 等. GC-MS分析康定独活根中的挥发油成分. 成都中医药大学学报, 2016, 39(1): 15-17.
|
|
|
[13] |
Ai Q Q, Gao B X, Lan Z Q, et al. GC-MS analysis of volatile oil from Heracleum souliei Radix. Journal of Chengdu University of Traditional Chinese Medicine, 2016, 39(1): 15-17.
|
|
|
[14] |
杨秀伟, 刘玉峰, 陶海燕, 等. 独活挥发油成分的GC-MS分析. 中国中药杂志, 2006, 31(8): 663-666.
|
|
|
[14] |
Yang X W, Liu Y F, Tao H Y, et al. GC-MS analysis of essential oils from Radix Angelicae pubescentis. China Journal of Chinese Materia Medica, 2006, 31(8): 663-666.
|
|
|
[15] |
裴媛, 谭初兵, 徐为人, 等. 当归苯酞类和萜类成分作用的虚拟评价. 中草药, 2010, 41(6): 938-941.
|
|
|
[15] |
Pei Y, Tan C B, Xu W R, et al. Virtual evaluation on activities of phthalides and terpenoids from Angelica sinensis. Chinese Traditional and Herbal Drugs, 2010, 41(6): 938-941.
|
|
|
[16] |
宫文霞, 周玉枝, 李肖, 等. 当归抗抑郁化学成分及药理作用研究进展. 中草药, 2016, 47(21): 3905-3911.
|
|
|
[16] |
Gong W X, Zhou Y Z, Li X, et al. Research progress in antidepressive active ingredients and pharmacological effects of Angelicae Sinensis Radix. Chinese Traditional and Herbal Drugs, 2016, 47(21): 3905-3911.
|
|
|
[17] |
张来宾, 吕洁丽, 陈红丽, 等. 当归中苯酞类成分及其药理作用研究进展. 中国中药杂志, 2016, 41(2): 167-176.
|
|
|
[17] |
Zhang L B, Lv J L, Chen H L, et al. Research progress of structures and pharmacological activities of phthalides from Angelica sinensis. China Journal of Chinese Materia Medica, 2016, 41(2): 167-176.
|
|
|
[18] |
蒋虎刚, 赵信科, 蔺文燕, 等. 基于HPLC-Q-TOF-MS/MS定性分析当归中多种香豆素类成分. 中国实验方剂学杂志, 2019, 25(13): 157-162.
|
|
|
[18] |
Jiang H G, Zhao X K, Lin W Y, et al. Qualitative analysis of multiple cumarins in angelicae sinensis Radix based on HPLC-Q-TOF-MS/MS. Chinese Journal of Experimental Traditional Medical Formulae, 2019, 25(13): 157-162.
|
|
|
[19] |
柳江华, 姚新生. 重齿毛当归化学成分及其抗人血小板与抗炎作用的研究. 沈阳药科大学学报, 1995, 12(2): 116.
|
|
|
[19] |
Liu J H, Yao X S. Study on chemical composition of Chinese sinensis and anti-inflammatory effect. Journal of Shenyang Pharmaceutical University, 1995, 12(2): 116.
|
|
|
[20] |
Awale S, Nakashima E M N, Kalauni S K, et al. Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation. Bioorganic & Medicinal Chemistry Letters, 2006, 16(3): 581-583.
doi: 10.1016/j.bmcl.2005.10.046
|
|
|
[21] |
丁希飞, 冯煦, 董云发, 等. 中药独活化学成分的研究. 中药材, 2008, 31(4): 516-518.
|
|
|
[21] |
Ding X F, Feng X, Dong Y F, et al. Studies on chemical constituents of the roots of Angelica pubescens. Journal of Chinese Medicinal Materials, 2008, 31(4): 516-518.
|
|
|
[22] |
蔡正军, 但飞君, 程凡, 等. 白根独活抗菌有效部位的化学成分研究. 中药材, 2008, 31(8): 1160-1162.
|
|
|
[22] |
Cai Z J, Dan F J, Cheng F, et al. Chemical constituents of antibacterial activity fraction of Angelica polymorpha. Journal of Chinese Medicinal Materials, 2008, 31(8): 1160-1162.
|
|
|
[23] |
Zaugg J, Eickmeier E, Rueda D C, et al. HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes. Fitoterapia, 2011, 82(3): 434-440.
doi: 10.1016/j.fitote.2010.12.001
|
|
|
[24] |
Thastrup O, Lemmich J. Furocoumarin glucosides of Angelica archangelica sub. species Litoralis. Phytochemistry, 1983, 22(9): 2035-2037.
doi: 10.1016/0031-9422(83)80039-9
|
|
|
[25] |
Waight E S, Razdan T K, Qadri B, et al. Chromones and coumarins from Skimmia laureola. Phytochemistry, 1987, 26(7): 2063-2069.
doi: 10.1016/S0031-9422(00)81759-8
|
|
|
[26] |
Hata K, Nishino T, Hirai Y, et al. On coumarins from the fruits of Angelica pubescens maxim (author’s transl). Yakugaku Zasshi, 1981, 101(1): 67-71.
pmid: 7252786
|
|
|
[27] |
Cai J N, Basnet P, Wang Z T, et al. Coumarins from the fruits of Cnidium monnieri. Journal of Natural Products, 2000, 63(4): 485-488.
pmid: 10785419
|
|
|
[28] |
Iossifova T, Vogler B, Kostova I. Escuside, a new coumarin-secoiridoid from Fraxinus ornus bark. Fitoterapia, 2002, 73(5): 386-389.
pmid: 12165333
|
|
|
[29] |
Yang X W, Zhang C Y, Zhang B G, et al. Novel coumarin and furan from the roots of Angelica pubescens f. biserrata. Journal of Asian Natural Products Research, 2009, 11(8): 698-703.
doi: 10.1080/10286020802619140
|
|
|
[30] |
Wang B, Liu X H, Zhou A, et al. Simultaneous analysis of coumarin derivatives in extracts of Radix Angelicae pubescentis (Duhuo) by HPLC-DAD-ESI-MSn technique. Anal Methods, 2014, 6(19): 7996-8002.
doi: 10.1039/C4AY01468E
|
|
|
[31] |
孙东东, 徐晓芳, 严世海, 等. 独活水提部位化学成分的HPLC-ESI-Q-TOF-MS分析. 天然产物研究与开发, 2014, 26(1): 69-76.
|
|
|
[31] |
Sun D D, Xu X F, Yan S H, et al. Analysis on chemical components from water extract of angelicae pubescentis Radix by high performance liquid chromatography-electrospray ionization-quadrupole-time of flight-mass spectrometry. Natural Product Research and Development, 2014, 26(1): 69-76.
|
|
|
[32] |
Chen Y F, Tsai H Y, Wu T S. Anti-inflammatory and analgesic activities from roots of Angelica pubescens. Planta Medica, 1995, 61(1): 2-8.
pmid: 7700984
|
|
|
[33] |
张清清, 冯媛, 李春花, 等. 基于UPLC-Q-TOF/MS技术快速鉴定当归中苯酞类和有机酸类成分. 中国药房, 2022, 33(5): 579-585, 591.
|
|
|
[33] |
Zhang Q Q, Feng Y, Li C H, et al. Rapid identification of phthalides and organic acids in Angelica sinensis based on UPLC-Q-TOF/MS. China Pharmacy, 2022, 33(5): 579-585, 591.
|
|
|
[34] |
Ma J P, Guo Z B, Jin L, et al. Phytochemical progress made in investigations of Angelica sinensis (Oliv.) Diels. Chinese Journal of Natural Medicines, 2015, 13(4): 241-249.
doi: 10.1016/S1875-5364(15)30010-8
|
|
|
[35] |
Wei W L, Zeng R, Gu C M, et al. Angelica sinensis in China:a review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis. Journal of Ethnopharmacology, 2016, 190: 116-141.
doi: 10.1016/j.jep.2016.05.023
|
|
|
[36] |
张胜, 李湘洲, 吴志平, 等. 植物多糖分离纯化与含量测定方法研究进展. 林产化学与工业, 2009, 29(S1): 238-242.
|
|
|
[36] |
Zhang S, Li X Z, Wu Z P, et al. Research progress on extraction, purification and content determination of plant polysaccharides. Chemistry and Industry of Forest Products, 2009, 29(S1): 238-242.
|
|
|
[37] |
牛雪芳, 廖奎, 汪子铃, 等. 当归多糖促进骨髓移植小鼠造血功能重建及其机制研究. 陆军军医大学学报, 2022, 44(16): 1621-1628.
|
|
|
[37] |
Niu X F, Liao K, Wang Z L, et al. Effect of Angelica sinensis polysaccharides on hematopoietic reconstitution in mice after bone marrow transplantation and its mechanism. Journal of Army Medical University, 2022, 44(16): 1621-1628.
|
|
|
[38] |
麻卲, 李晓茹, 吕志华, 等. 当归多糖对妊娠期易栓症大鼠的抗炎作用及对凝血功能的影响. 广州中医药大学学报, 2022, 39(3): 612-617.
|
|
|
[38] |
Ma S, Li X R, Lyu Z H, et al. Anti-inflammation effect of Angelica polysaccharide in rats with thrombophilia during pregnancy and impact on coagulation function. Journal of Guangzhou University of Traditional Chinese Medicine, 2022, 39(3): 612-617.
|
|
|
[39] |
Shen J, Zhang M Y, Zhang K, et al. Effect of Angelica polysaccharide on mouse myeloid-derived suppressor cells. Frontiers in Immunology, 2022, 13: 989230.
doi: 10.3389/fimmu.2022.989230
|
|
|
[40] |
张林维, 黄汝多. 当归水溶性多糖级分As-Ⅲa和As-Ⅲb的纯化鉴定与结构研究. 激光生物学报, 1999, 8(2): 122-126.
|
|
|
[40] |
Zhang L W, Huang R D. Purificatiton, characterization and structure analysis of polysaccharide As-Ⅲa and As-Ⅲb from Angelica sinensis. Acta Laser Biology Sinica, 1999, 8(2): 122-126.
|
|
|
[41] |
陈汝贤, 刘叶民, 王海燕, 等. 当归多糖X-C-3-Ⅱ的分离纯化与组成研究. 中国新药杂志, 2001, 10(6): 431-432.
|
|
|
[41] |
Chen R X, Liu Y M, Wang H Y, et al. Isolation, purification and composition of polysaccharide X-C-3-Ⅱ obtained from Angelica sinensis (Oliv.)Diels. Chinese New Drugs Journal, 2001, 10(6): 431-432.
|
|
|
[42] |
陈汝贤, 王海燕, 许鸿章, 等. 岷当归两个多糖组分的分离、纯化与鉴定. 中药材, 2001, 24(1): 36-37.
pmid: 11341028
|
|
|
[42] |
Chen R X, Wang H Y, Xu H Z, et al. Isolation, purification and determination of polysacchand X-C-3-Ⅲ and X-C-3-Ⅳ from Angelica sinensis (Oliv.) Diels. Journal of Chinese Medicinal Materials, 2001, 24(1): 36-37.
pmid: 11341028
|
|
|
[43] |
陈汝贤, 徐桂云, 王海燕, 等. 当归多糖XC-1的分离与结构研究. 化学通报, 2001, 64(6): 372-374.
|
|
|
[43] |
Chen R X, Xu G Y, Wang H Y, et al. Study on isolation and structure of polysaccharide XC-1 from Angelica sinesis (Oliv.) Diels. Chemistry, 2001, 64(6): 372-374.
|
|
|
[44] |
Wang Q J, Ding F, Zhu N N, et al. Determination of the compositions of polysaccharides from Chinese herbs by capillary zone electrophoresis with amperometric detection. Biomedical Chromatography, 2003, 17(7): 483-488.
pmid: 14598334
|
|
|
[45] |
Sun Y L, Tang J, Gu X H, et al. Water-soluble polysaccharides from Angelica sinensis (Oliv.) Diels: preparation, characterization and bioactivity. International Journal of Biological Macromolecules, 2005, 36(5): 283-289.
doi: 10.1016/j.ijbiomac.2005.07.005
|
|
|
[46] |
Yang X B, Zhao Y, Wang Q W, et al. Analysis of the monosaccharide components in Angelica polysaccharides by high performance liquid chromatography. Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry, 2005, 21(10): 1177-1180.
doi: 10.2116/analsci.21.1177
|
|
|
[47] |
孙元琳, 顾小红, 汤坚, 等. 当归水溶性多糖的分离、纯化及结构初步分析. 食品与生物技术学报, 2006, 25(1): 1-4.
|
|
|
[47] |
Sun Y L, Gu X H, Tang J, et al. The preparation, purification and structure analysis of water-soluble polysaccharides from Angelica sinensis. Journal of Food Science and Biotechnology, 2006, 25(1): 1-4.
|
|
|
[48] |
Cao W, Li X Q, Liu L, et al. Structural analysis of water-soluble glucans from the root of Angelica sinensis (Oliv.) Diels. Carbohydrate Research, 2006, 341(11): 1870-1877.
doi: 10.1016/j.carres.2006.04.017
|
|
|
[49] |
Yang T H, Jia M, Meng J, et al. Immunomodulatory activity of polysaccharide isolated from Angelica sinensis. International Journal of Biological Macromolecules, 2006, 39(4-5): 179-184.
doi: 10.1016/j.ijbiomac.2006.02.013
|
|
|
[50] |
王顺春, 施松善, 崔健, 等. 当归中一种杂多糖的分离纯化与结构鉴定. 中国药学杂志, 2007, 42(16): 1255-1258.
|
|
|
[50] |
Wang S C, Shi S S, Cui J, et al. Isolation and structure analysis of a hetero-polysaccharide from Angelica sinensis(Oliv.)Diels. Chinese Pharmaceutical Journal, 2007, 42(16): 1255-1258.
|
|
|
[51] |
Yang X B, Zhao Y, Zhou Y J, et al. Component and antioxidant properties of polysaccharide fractions isolated from Angelica sinensis (Oliv.) Diels. Biological & Pharmaceutical Bulletin, 2007, 30(10): 1884-1890.
|
|
|
[52] |
Yang X B, Zhao Y, Lv Y. In vivo macrophage activation and physicochemical property of the different polysaccharide fractions purified from Angelica sinensis. Carbohydrate Polymers, 2008, 71(3): 372-379.
doi: 10.1016/j.carbpol.2007.06.002
|
|
|
[53] |
Yang X B, Zhao Y, Li G L, et al. Chemical composition and immuno-stimulating properties of polysaccharide biological response modifier isolated from Radix Angelica sinensis. Food Chemistry, 2008, 106(1): 269-276.
doi: 10.1016/j.foodchem.2007.05.085
|
|
|
[54] |
曹蔚, 李小强, 侯颖, 等. 当归多糖APS-2a的结构分析及抗肿瘤作用研究. 中药材, 2008, 31(2): 261-266.
|
|
|
[54] |
Cao W, Li X Q, Hou Y, et al. Structural analysis and anti-tumor activity in vivo of polysaccharide APS-2a from Angelica sinensis. Journal of Chinese Medicinal Materials, 2008, 31(2): 261-266.
|
|
|
[55] |
Jiang J, Guo Y J, Niu A J. Extraction, characterization of Angelica sinensis polysaccharides and modulatory effect of the polysaccharides and Tai Chi exercise on oxidative injury in middle-aged women subjects. Carbohydrate Polymers, 2009, 77(2): 384-388.
doi: 10.1016/j.carbpol.2009.01.010
|
|
|
[56] |
Zhang S, He B, Ge J B, et al. Extraction, chemical analysis of Angelica sinensis polysaccharides and antioxidant activity of the polysaccharides in ischemia-reperfusion rats. International Journal of Biological Macromolecules, 2010, 47(4): 546-550.
doi: 10.1016/j.ijbiomac.2010.07.012
pmid: 20691723
|
|
|
[57] |
陈曦, 曹蔚, 孙阳, 等. 当归多糖APS-bⅡ的结构特征及体外抗肿瘤作用. 科学技术与工程, 2010, 10(8): 1839-1843.
|
|
|
[57] |
Chen X, Cao W, Sun Y, et al. Physicochemical properties and anti-tumor activities in vitro of Angelica sinensis polysaccharide APS-bII. Science Technology and Engineering, 2010, 10(8): 1839-1843.
|
|
|
[58] |
Cao W, Li X Q, Wang X, et al. Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels. International Journal of Biological Macromolecules, 2010, 46(1): 115-122.
doi: 10.1016/j.ijbiomac.2009.11.005
|
|
|
[59] |
Sun Y L, Cui S W, Tang J, et al. Structural features of pectic polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydrate Polymers, 2010, 80(2): 544-550.
doi: 10.1016/j.carbpol.2009.12.030
|
|
|
[60] |
Mo X L, Guo D K, Jiang Y G, et al. Isolation, structures and bioactivities of the polysaccharides from Radix Hedysari: a review. International Journal of Biological Macromolecules, 2022, 199: 212-222.
doi: 10.1016/j.ijbiomac.2021.12.095
|
|
|
[61] |
Liu W J, Xiao K M, Ren L, et al. Leukemia cells apoptosis by a newly discovered heterogeneous polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydrate Polymers, 2020, 241: 116279.
doi: 10.1016/j.carbpol.2020.116279
|
|
|
[62] |
董蕊, 王盼, 逯影. 炙甘草和当归黄酮类成分配伍治疗烫伤的剂型初步研究. 中国中药杂志, 2021, 46(22): 5810-5818.
doi: 10.19540/j.cnki.cjcmm.20210311.304
pmid: 34951169
|
|
|
[62] |
Dong R, Wang P, Lu Y. Combination of flavonoids in Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle and Angelicae Sinensis Radix in treatment of scalds: a preliminary study of dosage form. China Journal of Chinese Materia Medica, 2021, 46(22): 5810-5818.
doi: 10.19540/j.cnki.cjcmm.20210311.304
pmid: 34951169
|
|
|
[63] |
王涵, 董庆海, 吴福林, 等. ICP-MS同时测定当归中12种人体必需微量元素及5种重金属元素的含量. 特产研究, 2019, 41(2): 69-73, 95.
|
|
|
[63] |
Wang H, Dong Q H, Wu F L, et al. Simultaneous determination of 12 essential trace elements and 5 heavy metal elements in Angelica sinensis(Oliv.) Diels by ICP-MS. Special Wild Economic Animal and Plant Research, 2019, 41(2): 69-73, 95.
|
|
|
[64] |
胡静. 基于UPLC-Q-TOF-MS结合诊断离子与分子网络策略解析当归补血汤的化学成分. 太原: 山西大学, 2021.
|
|
|
[64] |
Hu J. Study on chemical components of Danggui buxue decoction based on UPLC-Q-TOF-MS combined with diagnostic ions and molecular network strategies. Taiyuan: Shanxi University, 2021.
|
|
|
[65] |
于潇, 王贵阳, 侯宇东, 等. 中药抗脑缺血再灌注损伤的作用及其机制的研究进展. 中草药, 2021, 52(5): 1471-1484.
|
|
|
[65] |
Yu X, Wang G Y, Hou Y D, et al. Research progress on effect and mechanism of traditional Chinese medicine against cerebral ischemia reperfusion injury. Chinese Traditional and Herbal Drugs, 2021, 52(5): 1471-1484.
|
|
|
[66] |
高雪亮, 秦立鹏, 李永章, 等. 当归多糖抑制PI3K/AKT途径阻碍平滑肌细胞增殖迁移. 天然产物研究与开发, 2021, 33(12): 2004-2010.
|
|
|
[66] |
Gao X L, Qin L P, Li Y Z, et al. Angelica polysaccharide inhibits the proliferation and migration of vascular smooth muscle cells by suppressing PI3K/AKT pathway. Natural Product Research and Development, 2021, 33(12): 2004-2010.
|
|
|
[67] |
王继龙, 陈方圆, 刘晓霞, 等. 当归提取物及其活性成分在化妆品中的应用. 香料香精化妆品, 2021(3): 101-104.
|
|
|
[67] |
Wang J L, Chen F Y, Liu X X, et al. Application of Angelica sinensis extracts and its active components in cosmetics. Flavour Fragrance Cosmetics, 2021(3): 101-104.
|
|
|
[68] |
乔彩红, 李斌山, 张忠, 等. 当归茎叶精油对四种果蔬采后腐败真菌的抑制活性. 食品与发酵工业, 2022, 48(11): 206-212.
|
|
|
[68] |
Qiao C H, Li B S, Zhang Z, et al. Antifungal activities of essential oil from Angelica sinensis leaf against postharvest pathogenic fungi of fruit and vegetables. Food and Fermentation Industries, 2022, 48(11): 206-212.
|
|
|
[69] |
Feng S H, Zhao B, Zhan X, et al. Danggui buxue decoction in the treatment of metastatic colon cancer: network pharmacology analysis and experimental validation. Drug Design, Development and Therapy, 2021, 15: 705-720.
doi: 10.2147/DDDT.S293046
|
|
|
[70] |
王雪振, 张小雨, 牟悦, 等. 当归补血汤在恶性肿瘤中作用的研究进展. 中国实验方剂学杂志, 2022, 28(9): 214-220.
|
|
|
[70] |
Wang X Z, Zhang X Y, Mou Y, et al. Danggui buxuetang in malignant tumor: a review. Chinese Journal of Experimental Traditional Medical Formulae, 2022, 28(9): 214-220.
|
|
|
[71] |
武铮, 程木子, 安士恩, 等. 当归多糖对D-半乳糖致衰老模型小鼠的影响. 中国临床药理学杂志, 2021, 37(12): 1577-1580.
|
|
|
[71] |
Wu Z, Cheng M Z, An S E, et al. Effect of Angelica sinensis polysaccharide on D-galactose-induced aging model mice. The Chinese Journal of Clinical Pharmacology, 2021, 37(12): 1577-1580.
|
|
|
[72] |
李泽, 尹芳, 杨苗, 等. 基于CREB/Bcl-2信号通路探究当归芍药散改善Aβ诱导的胆碱能神经元凋亡的作用机制. 中草药, 2022, 53(8): 2376-2382.
|
|
|
[72] |
Li Z, Yin F, Yang M, et al. Mechanism of Danggui Shaoyao San on ameliorating Aβ-induced apoptosis of cholinergic neurons based on CREB/Bcl-2 signaling pathway. Chinese Traditional and Herbal Drugs, 2022, 53(8): 2376-2382.
|
|
|
[73] |
宋祯彦, 夏小芳, 王玉珂, 等. 当归芍药散通过调控NLRP3/Caspase-1信号通路抑制AD大鼠神经炎症的作用. 中国实验方剂学杂志, 2021, 27(19): 1-8.
|
|
|
[73] |
Song Z Y, Xia X F, Wang Y K, et al. Danggui Shaoyaosan inhibits neuroinflammation in AD rats by regulating NLRP3/Caspase-1 pathway. Chinese Journal of Experimental Traditional Medical Formulae, 2021, 27(19): 1-8.
|
|
|
[74] |
王志旺, 李荣科, 蔺兴遥, 等. 当归主咳逆上气的中医药理论及现代研究与应用. 新中医, 2016, 48(1): 4-6.
|
|
|
[74] |
Wang Z W, Li R K, Lin X Y, et al. Traditional Chinese medicine theory and modern research and application of Angelica main cough inverse Shangqi. Journal of New Chinese Medicine, 2016, 48(1): 4-6.
|
|
|
[75] |
张艳, 陈丽, 李金娟, 等. 当归多糖对哮喘幼龄小鼠抗氧化系统的影响. 中国临床药理学杂志, 2021, 37(17): 2312-2315.
|
|
|
[75] |
Zhang Y, Chen L, Li J J, et al. Effect of Angelica sinensis polysaccharide on antioxidant system in asthmatic young mice. The Chinese Journal of Clinical Pharmacology, 2021, 37(17): 2312-2315.
|
|
|
[76] |
肖含先之. 当归多糖通过调控Wnt/β-catenin信号减轻5-氟尿嘧啶所致骨髓基质细胞增殖抑制. 重庆: 重庆医科大学, 2019.
|
|
|
[76] |
Xiao H X Z. Angelica sinensis polysaccharides ameliorate 5-fluorouracil-induced bone marrow stromal cell proliferation inhibition via regulating Wnt/beta-catenin signaling pathway. Chongqing: Chongqing Medical University, 2019.
|
|
|
[77] |
何俊华. 当归补血汤促骨髓基质细胞黏附机制及其造血功能调控. 广州: 广东药科大学, 2018.
|
|
|
[77] |
He J H. Adhesion mechanism of Danggui buxue Tang on bone marrow stromal cells and its effect on hematopoietic function. Guangzhou: Guangdong Pharmaceutical University, 2018.
|
|
|
[78] |
陈维达, 徐龙晋, 张静, 等. 当归补血汤对再障小鼠骨髓造血及线粒体自噬的实验研究. 中药药理与临床, 2019, 35(1): 14-18.
|
|
|
[78] |
Chen W D, Xu L J, Zhang J, et al. Experimental study of Dangguibuxue Decoction on bone marrow hematopoiesis and mitophagy in aplastic anemia mice. Pharmacology and Clinics of Chinese Materia Medica, 2019, 35(1): 14-18.
|
|
|
[79] |
Cheng C Y, Kao S T, Lee Y C. Angelica sinensis extract protects against ischemia-reperfusion injury in the Hippocampus by activating p38 MAPK-mediated p90RSK/p-Bad and p90RSK/CREB/BDNF signaling after transient global cerebral ischemia in rats. Journal of Ethnopharmacology, 2020, 252: 112612.
doi: 10.1016/j.jep.2020.112612
|
|
|
[80] |
郭静. 当归饮子加减方对慢性荨麻疹抗过敏作用及机理研究. 成都: 成都中医药大学, 2012.
|
|
|
[80] |
Guo J. The Angelica yinzi decoction on chronic urticaria anti-allergy effects and mechanisms. Chengdu: Chengdu University of TCM, 2012.
|
|
|
[81] |
蔡义思, 李佳钰, 陆麒瑾, 等. 基于定量蛋白质组学研究当归拈痛汤对风湿热痹佐剂性关节炎大鼠的作用机制. 中国实验方剂学杂志, 2022, 28(13): 62-70.
|
|
|
[81] |
Cai Y S, Li J Y, Lu Q J, et al. Mechanism of Danggui Niantongtang on adjuvant arthritis rats with wind-dampness-heat arthralgia based on quantitative proteomics. Chinese Journal of Experimental Traditional Medical Formulae, 2022, 28(13): 62-70.
|
|
|
[82] |
林婧, 宁平. 常用根茎类中药在美白化妆品中的应用现状研究. 香料香精化妆品, 2020(2): 62-65.
|
|
|
[82] |
Lin J, Ning P. Study on the application of common rhizome traditional Chinese medicine in whitening cosmetics. Flavour Fragrance Cosmetics, 2020(2): 62-65.
|
|
|
[83] |
郑荣蕾, 戴静, 何勇志, 等. 质量标志物(Q-Marker)预测分析途径研究进展. 中草药, 2021, 52(9): 2566-2574.
|
|
|
[83] |
Zheng R L, Dai J, He Y Z, et al. Research progress on prediction and analysis approaches of quality markers(Q-Marker). Chinese Traditional and Herbal Drugs, 2021, 52(9): 2566-2574.
|
|
|
[84] |
张露云. 东北三省当归属中药资源研究与药理活性评价. 长春: 长春中医药大学, 2020.
|
|
|
[84] |
Zhang L Y. Research on Chinese medicine resources and evaluation of pharmacological activity of Angelica L. in the northeast three provinces. Changchun: Changchun University of Chinese Medicine, 2020.
|
|
|
[85] |
张雷, 杨秀伟. UFLC-MS/MS法分析不同来源白芷中9个新型呋喃香豆素. 药物分析杂志, 2018, 38(2): 214-220.
|
|
|
[85] |
Zhang L, Yang X W. Analysis of nine furanocoumarins in Angelicae Dahuricae Radix from different regions by ultra-fast liquid chromatography coupled with triple quadrupole mass spectrometer. Chinese Journal of Pharmaceutical Analysis, 2018, 38(2): 214-220.
|
|
|
[86] |
冯慧敏, 李玥, 罗旭东, 等. 当归化学成分和药理作用研究进展及质量标志物的预测分析. 中华中医药学刊, 2022, 40(4): 159-166.
|
|
|
[86] |
Feng H M, Li Y, Luo X D, et al. Research progress on chemical constituents and pharmacological effects of Danggui (Radix Angelicae sinensis) and prediction analysis on its quality markersfull text replacement. Chinese Archives of Traditional Chinese Medicine, 2022, 40(4): 159-166.
|
|
|
[87] |
刘志荣, 张明童, 张平, 等. 高效液相色谱法同时测定白芷药材中的9种香豆素成分及其质量分析. 化学试剂, 2022, 44(10):1513-1518.
|
|
|
[87] |
Liu Z Y, Zhang M T, Zhang P, et al. Simultaneous determination and quality analysis of nine coumarin components in Angelica dahurica by high performance liquid chromatography. Chemical Reagents, 2022, 44(10):1513-1518.
|
|
|
[88] |
邓雪琪, 管小军, 黄娜娜, 等. HPLC法同时测定当归中8种成分. 中成药, 2020, 42(8): 2075-2079.
|
|
|
[88] |
Deng X Q, Guan X J, Huang N N, et al. Simultaneous determination of eight constituents in Angelica sinensis by HPLC . Chinese Traditional Patent Medicine, 2020, 42(8): 2075-2079.
|
|
|
[89] |
Li X, Yao Y X, Wang X X, et al. Quantification analysis of 13 organic components and 8 inorganic elements in Angelica sinensis radix and its different parts combined with chemical recognition pattern. Journal of Analytical Methods in Chemistry, 2020, 2020: 8836184.
|
|
|
[90] |
刘明亮, 张奥, 冯薇, 等. UHPLC-Q-TOF-MS分析当归在饮片与当归建中汤标准汤剂中3类成分的变化. 中国药学杂志, 2022, 57(8): 613-622.
|
|
|
[90] |
Liu M L, Zhang A, Feng W, et al. Comparation and analysis of three kinds of components in angelicae sinensis Radix pieces and Danggui Jianzhong Decoction by UHPLC-Q-TOF-MS. Chinese Pharmaceutical Journal, 2022, 57(8): 613-622.
|
|
|
[91] |
张君冬, 尹仁芳, 陈琦, 等. 基于网络药理学及分子对接探讨当归补血汤治疗动脉粥样硬化潜在作用机制研究. 世界科学技术:中医药现代化, 2021, 23(4): 1076-1085.
|
|
|
[91] |
Zhang J D, Yin R F, Chen Q, et al. Study on the potential mechanism of Danggui buxue decoction for arteriosclerosis based on network pharmacology and molecular docking. Modernization of Traditional Chinese Medicine and Materia Medica:World Science and Technology, 2021, 23(4): 1076-1085.
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