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Advances in Engineering Yeast Chassis for Producing Aromatic Compounds |
Hui-min LI,Bin JIA,Xia LI,Duo LIU**() |
Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering of Ministry of Education,School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China |
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Abstract Aromatic compounds including lots of species are in high demand and widely used in many areas. The synthesis of aromatic compounds by constructing microbial cell factories has unique advantages and industrial applications. Yeast chassis is often used to build cell factories due to its clear genetic background, well-performed gene manipulation tools, and mature industrial system. A series of advances has been made in the production of aromatic compounds by engineering yeast chassis, and several feasible solutions have been proposed to solve key problems. In view of the strategies and challenges of yeast synthesis of aromatic compounds, this paper systematically reviews and elaborates on the five aspects, namely, the aromatic compound synthetic pathway modification, utilization of diverse carbon sources and modification of transport systems, genome multi-target modification, special yeast chassis and microbial consortium construction, and applications of synthetic biology high-throughput technologies, and provides ideas for the construction and engineering of yeast chassis for producing aromatic compounds.
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Received: 21 April 2022
Published: 04 November 2022
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Corresponding Authors:
Duo LIU
E-mail: duo_liu0@tju.edu.cn
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