Application Progress of Organoids-on-a-chip in Medical Research

doi:10.13523/j.cb.2106050

China Biotechnology

2022, Vol. 42

Issue (1/2): 112-118 DOI: 10.13523/j.cb.2106050

Orginal Article

Application Progress of Organoids-on-a-chip in Medical Research

FENG Xiao-ying^1,²,MENG Qian^1,²,CHEN Wei¹,YU Lei^3,^**(

),HUANG Wei-ren^1,^**(

)

1 State and Local Government Joint Engineering Laboratory of Synthetic Biology Medicine and Clinical Application of Key Technologies, Shenzhen Second Hospital, Shenzhen 518036, China
2 Shantou University Medical College, Shantou 515041, China
3 Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

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Abstract

Compared with 2D cell model and animal model, organoids can better reproduce the key structural and functional characteristics of the source organs, which have been widely studied and applied in the biomedical field. Organoids-on-a-chip combines organoid culture chamber, microfluidics and other functional units, which can not only be designed according to researchers' cognition of target organs, but also simulate the complexity of target organs. With the characteristics of high throughput and high sensitivity, it can control and detect the changes of the microenvironment in which organoids are located. This review summarizes the units and applications of organoids-on-a-chip in medical research, including construction of biological models and disease models, drug research and development, and immune evaluation, and discusses the shortcomings of organoids-on-a-chip in current research and application and proposes directions for future research. The aim is to provide a powerful strategy for the study of disease or biological development mechanism and preclinical research.

Key words： Organoids-on-a-chip Microfluidics Drug screening Construction of models Evaluation of immune effect

Received: 29 June 2021 Published: 03 March 2022

ZTFLH:

Q819

Corresponding Authors: Lei YU,Wei-ren HUANG E-mail: lei.yu@siat.ac.cn;pony8980@163.com

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Cite this article:

FENG Xiao-ying,MENG Qian,CHEN Wei,YU Lei,HUANG Wei-ren. Application Progress of Organoids-on-a-chip in Medical Research. China Biotechnology, 2022, 42(1/2): 112-118.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2106050 OR https://manu60.magtech.com.cn/biotech/Y2022/V42/I1/2/112


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