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Advance of microRNA Therapeutics in Cancer and Other Diseases |
TANG De-ping1,XING Meng-jie1,2,SONG Wen-tao1,YAO Hui-hui1,MAO Ai-hong2,**() |
1 School of Biological & Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070,China 2 Gansu Provincial Academic Institute for Medical Research, Lanzhou 730050,China |
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Abstract microRNAs (miRNAs) are a class of endogenous, small non-coding RNAs (about 22 nt) that have critical roles in gene expression. Functional studies have identified miRNAs dysregulation as a cause in many human diseases, including cancer, viral infection, and autoimmune disorders. Restoring or suppressing miRNAs function and activity has become an attractive therapeutic method for the management of cancer and other diseases. Several miRNA-based therapeutics have reached clinical development, including a mimic of the tumor suppressor miR-34 for treating cancer and anti-miRs targeted miR-122 for treating HCV infection. In this review, we summarize the recent advances in our knowledge of miRNA therapeutics in cancer and other diseases and discuss ongoing challenges to ensure the safety and efficacy of miRNA therapeutics in vivo.
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Received: 15 June 2021
Published: 01 December 2021
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Corresponding Authors:
Ai-hong MAO
E-mail: maoaih@aliyun.com
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